Bioactive compounds derived from food matrices with therapeutic potential for Sars-Cov-2 infection: A review of in silico Studies

• Autor(a) principal: Costa, Jardel Alves da
• Data de Publicação: 2021
• Outros Autores: Lima, Diêgo de Oliveira, Carvalho, Ana Gessica dos Santos, Martins, Jorddam Almondes, Santos, Maria do Socorro dos, Sousa, Danielle Gomes de, Carvalho, Gildelânia da Silva, Barros, Fatima Rosane, Ferreira, Karine Rodrigues, Barros, Gabrielly Martins de, Fontinele, Renata Rodrigues Costa, Silva, Jéssica Ellen Alves da, Santos, Antônia Janikely Silva, Rocha, Lucineide de Brito
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/17178
• topic: Compostos bioativos derivados de alimentos; Replicação; SARS-CoV-2; In silico.; Compuestos bioactivos derivados de alimentos; Replicación; SARS-CoV-2; In silico.; Bioactive compounds derived from food; Replication; SARS-CoV-2; In silico.

The study aimed to review the literature on available scientific evidence on the therapeutic potential that some bioactive compounds can exert on Sars-Cov-2 infection, based on tests performed with molecular docking techniques. The integrative review was carried out based on searches in electronic databases about publications of original articles written in English and Portuguese, between the years 2019 to 2021. The searches were carried out in the following databases: Science Direct (Elsevier Virtual Library), Scielo (Scientific Electronic Library Online), Pubmed/Medline (Medical Literature Analysis and Retrievel System Online) and VHL (Virtual Health Library), using as descriptors in health according to the DeCS/MeSH platform the words: Derived bioactive compounds of food, replication, SARS-CoV-2, in silico, in English and Portuguese, using the term ''and'' as a Boolean operator. After the search and selection process using the criteria mentioned in the methodology, 6 articles were selected. Natural products derived from food matrices could be a valuable source of new bioactive compounds to fight the COVID-19 pandemic. According to the results reported in this review, several natural compounds, including polyphenols and flavonoids, have shown the ability to prevent SARS-CoV-2 replication by inhibiting the main virus proteases, thus mitigating the clinical consequences of the infection, according to the in silico technique used.