The interrelationships between depression and intestinal dysbiosis: an integrative review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/8063 |
Resumo: | Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome. |
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The interrelationships between depression and intestinal dysbiosis: an integrative reviewLas interrelaciones entre la depresión y la disbiosis intestinal: una revisión integradoraAs inter-relações entre a depressão e a disbiose intestinal: uma revisão integrativaTranstorno depressivoMicrobioma intestinalIntestino-cérebro.Desorden depresivoMicrobioma intestinalIntestino-cerebro.Depressive disorderIntestinal microbiomeIntestine-brain.Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome.La depresión, al igual que otros trastornos mentales, tiene causas multifactoriales y criterios diagnósticos específicos que sirven como pautas para un tratamiento prometedor. Los desequilibrios del eje intestino-cerebro, por disbiosis de la microbiota intestinal, han revelado importantes relaciones con trastornos psiquiátricos y enfermedades intestinales. En este seguimiento, el estudio tiene como objetivo caracterizar la relación entre las desregulaciones funcionales del eje intestino-cerebro, específicamente entre la disbiosis y la psicopatología de la depresión. De las búsquedas en las bases de datos PubMed, BVS y EBSCOhost, se seleccionaron 8 artículos con el criterio metodológico de ser empíricos y experimentales para la revisión integradora de la literatura. Se indujo disbiosis y/o depresión mediante modelos de estrés en todos los animales utilizados en los experimentos. La bidireccionalidad del eje se encontró en todos los artículos revisados. Ambas disfunciones se afectan entre sí, involucrando respuestas psicomotoras, metabólicas e inflamatorias, señalando posibles dianas terapéuticas, con el objetivo de reequilibrar el microbioma intestinal.A depressão, bem como os demais transtornos mentais, possui causas multifatoriais e critérios diagnósticos específicos que servem de norte para um tratamento promissor. Desbalanços do eixo intestino-cérebro, por meio da disbiose da microbiota intestinal têm revelado importantes relações com os transtornos psiquiátricos e doenças intestinais. Neste seguimento, o estudo objetiva caracterizar a relação entre as desregulações funcionais do eixo intestino-cérebro, especificamente entre a disbiose e a psicopatologia da depressão. A partir de buscas nas bases de dados PubMed, BVS e EBSCOhost, foram selecionados 8 artigos com o critério metodológico de serem empíricos e experimentais para a revisão integrativa de literatura. A disbiose e/ou a depressão foram induzidas via modelos de estresse em todos os animais utilizados nos experimentos. A bidirecionalidade do eixo foi constatada em todos os artigos revisados. Ambas as disfunções se afetam mutuamente, envolvendo respostas psicomotoras, metabólicas e inflamatórias, apontando ainda possíveis alvos terapêuticos, visando reequilibrar o microbioma intestinal. Research, Society and Development2020-09-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/806310.33448/rsd-v9i10.8063Research, Society and Development; Vol. 9 No. 10; e149108063Research, Society and Development; Vol. 9 Núm. 10; e149108063Research, Society and Development; v. 9 n. 10; e1491080632525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/8063/7309Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanellahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Rosa, Josiell Raysel daSouza, Mauro Celso deZanella, Michele 2020-10-31T12:03:23Zoai:ojs.pkp.sfu.ca:article/8063Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:37.499654Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The interrelationships between depression and intestinal dysbiosis: an integrative review Las interrelaciones entre la depresión y la disbiosis intestinal: una revisión integradora As inter-relações entre a depressão e a disbiose intestinal: uma revisão integrativa |
title |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
spellingShingle |
The interrelationships between depression and intestinal dysbiosis: an integrative review Rosa, Josiell Raysel da Transtorno depressivo Microbioma intestinal Intestino-cérebro. Desorden depresivo Microbioma intestinal Intestino-cerebro. Depressive disorder Intestinal microbiome Intestine-brain. |
title_short |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
title_full |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
title_fullStr |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
title_full_unstemmed |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
title_sort |
The interrelationships between depression and intestinal dysbiosis: an integrative review |
author |
Rosa, Josiell Raysel da |
author_facet |
Rosa, Josiell Raysel da Souza, Mauro Celso de Zanella, Michele |
author_role |
author |
author2 |
Souza, Mauro Celso de Zanella, Michele |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Rosa, Josiell Raysel da Souza, Mauro Celso de Zanella, Michele |
dc.subject.por.fl_str_mv |
Transtorno depressivo Microbioma intestinal Intestino-cérebro. Desorden depresivo Microbioma intestinal Intestino-cerebro. Depressive disorder Intestinal microbiome Intestine-brain. |
topic |
Transtorno depressivo Microbioma intestinal Intestino-cérebro. Desorden depresivo Microbioma intestinal Intestino-cerebro. Depressive disorder Intestinal microbiome Intestine-brain. |
description |
Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/8063 10.33448/rsd-v9i10.8063 |
url |
https://rsdjournal.org/index.php/rsd/article/view/8063 |
identifier_str_mv |
10.33448/rsd-v9i10.8063 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/8063/7309 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanella https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanella https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 10; e149108063 Research, Society and Development; Vol. 9 Núm. 10; e149108063 Research, Society and Development; v. 9 n. 10; e149108063 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052658423431168 |