The interrelationships between depression and intestinal dysbiosis: an integrative review

Detalhes bibliográficos
Autor(a) principal: Rosa, Josiell Raysel da
Data de Publicação: 2020
Outros Autores: Souza, Mauro Celso de, Zanella, Michele
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/8063
Resumo: Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome.
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spelling The interrelationships between depression and intestinal dysbiosis: an integrative reviewLas interrelaciones entre la depresión y la disbiosis intestinal: una revisión integradoraAs inter-relações entre a depressão e a disbiose intestinal: uma revisão integrativaTranstorno depressivoMicrobioma intestinalIntestino-cérebro.Desorden depresivoMicrobioma intestinalIntestino-cerebro.Depressive disorderIntestinal microbiomeIntestine-brain.Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome.La depresión, al igual que otros trastornos mentales, tiene causas multifactoriales y criterios diagnósticos específicos que sirven como pautas para un tratamiento prometedor. Los desequilibrios del eje intestino-cerebro, por disbiosis de la microbiota intestinal, han revelado importantes relaciones con trastornos psiquiátricos y enfermedades intestinales. En este seguimiento, el estudio tiene como objetivo caracterizar la relación entre las desregulaciones funcionales del eje intestino-cerebro, específicamente entre la disbiosis y la psicopatología de la depresión. De las búsquedas en las bases de datos PubMed, BVS y EBSCOhost, se seleccionaron 8 artículos con el criterio metodológico de ser empíricos y experimentales para la revisión integradora de la literatura. Se indujo disbiosis y/o depresión mediante modelos de estrés en todos los animales utilizados en los experimentos. La bidireccionalidad del eje se encontró en todos los artículos revisados. Ambas disfunciones se afectan entre sí, involucrando respuestas psicomotoras, metabólicas e inflamatorias, señalando posibles dianas terapéuticas, con el objetivo de reequilibrar el microbioma intestinal.A depressão, bem como os demais transtornos mentais, possui causas multifatoriais e critérios diagnósticos específicos que servem de norte para um tratamento promissor. Desbalanços do eixo intestino-cérebro, por meio da disbiose da microbiota intestinal têm revelado importantes relações com os transtornos psiquiátricos e doenças intestinais. Neste seguimento, o estudo objetiva caracterizar a relação entre as desregulações funcionais do eixo intestino-cérebro, especificamente entre a disbiose e a psicopatologia da depressão.  A partir de buscas nas bases de dados PubMed, BVS e EBSCOhost, foram selecionados 8 artigos com o critério metodológico de serem empíricos e experimentais para a revisão integrativa de literatura. A disbiose e/ou a depressão foram induzidas via modelos de estresse em todos os animais utilizados nos experimentos. A bidirecionalidade do eixo foi constatada em todos os artigos revisados. Ambas as disfunções se afetam mutuamente, envolvendo respostas psicomotoras, metabólicas e inflamatórias, apontando ainda possíveis alvos terapêuticos, visando reequilibrar o microbioma intestinal. Research, Society and Development2020-09-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/806310.33448/rsd-v9i10.8063Research, Society and Development; Vol. 9 No. 10; e149108063Research, Society and Development; Vol. 9 Núm. 10; e149108063Research, Society and Development; v. 9 n. 10; e1491080632525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/8063/7309Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanellahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Rosa, Josiell Raysel daSouza, Mauro Celso deZanella, Michele 2020-10-31T12:03:23Zoai:ojs.pkp.sfu.ca:article/8063Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:37.499654Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The interrelationships between depression and intestinal dysbiosis: an integrative review
Las interrelaciones entre la depresión y la disbiosis intestinal: una revisión integradora
As inter-relações entre a depressão e a disbiose intestinal: uma revisão integrativa
title The interrelationships between depression and intestinal dysbiosis: an integrative review
spellingShingle The interrelationships between depression and intestinal dysbiosis: an integrative review
Rosa, Josiell Raysel da
Transtorno depressivo
Microbioma intestinal
Intestino-cérebro.
Desorden depresivo
Microbioma intestinal
Intestino-cerebro.
Depressive disorder
Intestinal microbiome
Intestine-brain.
title_short The interrelationships between depression and intestinal dysbiosis: an integrative review
title_full The interrelationships between depression and intestinal dysbiosis: an integrative review
title_fullStr The interrelationships between depression and intestinal dysbiosis: an integrative review
title_full_unstemmed The interrelationships between depression and intestinal dysbiosis: an integrative review
title_sort The interrelationships between depression and intestinal dysbiosis: an integrative review
author Rosa, Josiell Raysel da
author_facet Rosa, Josiell Raysel da
Souza, Mauro Celso de
Zanella, Michele
author_role author
author2 Souza, Mauro Celso de
Zanella, Michele
author2_role author
author
dc.contributor.author.fl_str_mv Rosa, Josiell Raysel da
Souza, Mauro Celso de
Zanella, Michele
dc.subject.por.fl_str_mv Transtorno depressivo
Microbioma intestinal
Intestino-cérebro.
Desorden depresivo
Microbioma intestinal
Intestino-cerebro.
Depressive disorder
Intestinal microbiome
Intestine-brain.
topic Transtorno depressivo
Microbioma intestinal
Intestino-cérebro.
Desorden depresivo
Microbioma intestinal
Intestino-cerebro.
Depressive disorder
Intestinal microbiome
Intestine-brain.
description Depression, as well as other mental disorders, has multifactorial causes and specific diagnostic criteria that serve as guidelines for a promising treatment. Imbalances of the intestine-brain axis, through dysbiosis of the intestinal microbiota, have proved to be important with psychiatric disorders and intestinal diseases. In this follow-up, the study aims to characterize the relationship between the deregulations directed from the gut-brain axis, specifically between dysbiosis and the psychopathology of depression. From searches in the PubMed, BVS and EBSCOhost databases, 8 articles were selected with the methodological criterion of being empirical and experimental for an integrative literature review. Dysbiosis and/or depression were induced via stress models in all animals used in the experiments. The bidirectionality of the axis was found in all the reviewed articles. Both dysfunctions affect each other, involving psychomotor, metabolic, and inflammatory responses, still possible therapeutic targets, elevate the rebalancing of the intestinal microbiome.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/8063
10.33448/rsd-v9i10.8063
url https://rsdjournal.org/index.php/rsd/article/view/8063
identifier_str_mv 10.33448/rsd-v9i10.8063
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/8063/7309
dc.rights.driver.fl_str_mv Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanella
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Josiell Raysel da Rosa; Mauro Celso de Souza; Michele Zanella
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 10; e149108063
Research, Society and Development; Vol. 9 Núm. 10; e149108063
Research, Society and Development; v. 9 n. 10; e149108063
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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