Aged rats under zoledronic acid therapy and oral surgery
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jcms.2017.02.002 http://hdl.handle.net/11449/178717 |
Resumo: | Introduction Aging brings a number of health conditions that can compromise the healing process in elderly individuals, significantly when it comes to bone tissue. The aim of the present study was to analyze the effects of zoledronic acid (ZL) therapy on socket healing of aged male rats. Materials and methods Twenty-four Wistar male rats, 20 months old, underwent surgical procedures for the extraction of the upper right incisor and were divided into two groups according to the treatment: Control (C) – intravenous (IV) 0.9% saline, ZL – 0.035 mg/kg of IV zoledronic acid, both every 15 days. At the fifth dose of both substances, tooth extractions were performed and the animals were euthanized after 14 and 28 days. Results IV administration of ZL caused OPG-RANKL system imbalance, resulting in deficient bone formation and remodeling and alteration of osteoclast morphology, as well as maintaining persistent inflammation during the healing period. Conclusions IV administration of ZL delayed extracted dental socket healing of aged rats, but not enough to cause osteonecrosis, raising a question about different responses to IV BP therapy considering animal age. |
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Aged rats under zoledronic acid therapy and oral surgeryAgingBisphosphonateOral surgeryRatsIntroduction Aging brings a number of health conditions that can compromise the healing process in elderly individuals, significantly when it comes to bone tissue. The aim of the present study was to analyze the effects of zoledronic acid (ZL) therapy on socket healing of aged male rats. Materials and methods Twenty-four Wistar male rats, 20 months old, underwent surgical procedures for the extraction of the upper right incisor and were divided into two groups according to the treatment: Control (C) – intravenous (IV) 0.9% saline, ZL – 0.035 mg/kg of IV zoledronic acid, both every 15 days. At the fifth dose of both substances, tooth extractions were performed and the animals were euthanized after 14 and 28 days. Results IV administration of ZL caused OPG-RANKL system imbalance, resulting in deficient bone formation and remodeling and alteration of osteoclast morphology, as well as maintaining persistent inflammation during the healing period. Conclusions IV administration of ZL delayed extracted dental socket healing of aged rats, but not enough to cause osteonecrosis, raising a question about different responses to IV BP therapy considering animal age.São Paulo State University (Unesp) (Head: Prof. W. R. Poi) School of Dentistry Araçatuba, Rua José Bonifácio 1193School of Dentistry Sagrado Coração University – USC, Rua Irmã Arminda 10-50São Paulo State University (Unesp) (Head: Prof. W. R. Poi) School of Dentistry Araçatuba, Rua José Bonifácio 1193Universidade Estadual Paulista (Unesp)Sagrado Coração University – USCMatsumoto, Mariza Akemi [UNESP]de Abreu Furquim, Elisa Mara [UNESP]Gonçalves, Alaíde [UNESP]Santiago-Júnior, Joel FerreiraSaraiva, Patrícia PintoCardoso, Camila LopesMunerato, Marcelo SallesOkamoto, Roberta [UNESP]2018-12-11T17:31:48Z2018-12-11T17:31:48Z2017-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article781-787application/pdfhttp://dx.doi.org/10.1016/j.jcms.2017.02.002Journal of Cranio-Maxillofacial Surgery, v. 45, n. 5, p. 781-787, 2017.1878-41191010-5182http://hdl.handle.net/11449/17871710.1016/j.jcms.2017.02.0022-s2.0-850153444852-s2.0-85015344485.pdf8621510886887389Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cranio-Maxillofacial Surgery1,033info:eu-repo/semantics/openAccess2023-11-24T06:12:02Zoai:repositorio.unesp.br:11449/178717Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:34:13.604245Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aged rats under zoledronic acid therapy and oral surgery |
title |
Aged rats under zoledronic acid therapy and oral surgery |
spellingShingle |
Aged rats under zoledronic acid therapy and oral surgery Matsumoto, Mariza Akemi [UNESP] Aging Bisphosphonate Oral surgery Rats |
title_short |
Aged rats under zoledronic acid therapy and oral surgery |
title_full |
Aged rats under zoledronic acid therapy and oral surgery |
title_fullStr |
Aged rats under zoledronic acid therapy and oral surgery |
title_full_unstemmed |
Aged rats under zoledronic acid therapy and oral surgery |
title_sort |
Aged rats under zoledronic acid therapy and oral surgery |
author |
Matsumoto, Mariza Akemi [UNESP] |
author_facet |
Matsumoto, Mariza Akemi [UNESP] de Abreu Furquim, Elisa Mara [UNESP] Gonçalves, Alaíde [UNESP] Santiago-Júnior, Joel Ferreira Saraiva, Patrícia Pinto Cardoso, Camila Lopes Munerato, Marcelo Salles Okamoto, Roberta [UNESP] |
author_role |
author |
author2 |
de Abreu Furquim, Elisa Mara [UNESP] Gonçalves, Alaíde [UNESP] Santiago-Júnior, Joel Ferreira Saraiva, Patrícia Pinto Cardoso, Camila Lopes Munerato, Marcelo Salles Okamoto, Roberta [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Sagrado Coração University – USC |
dc.contributor.author.fl_str_mv |
Matsumoto, Mariza Akemi [UNESP] de Abreu Furquim, Elisa Mara [UNESP] Gonçalves, Alaíde [UNESP] Santiago-Júnior, Joel Ferreira Saraiva, Patrícia Pinto Cardoso, Camila Lopes Munerato, Marcelo Salles Okamoto, Roberta [UNESP] |
dc.subject.por.fl_str_mv |
Aging Bisphosphonate Oral surgery Rats |
topic |
Aging Bisphosphonate Oral surgery Rats |
description |
Introduction Aging brings a number of health conditions that can compromise the healing process in elderly individuals, significantly when it comes to bone tissue. The aim of the present study was to analyze the effects of zoledronic acid (ZL) therapy on socket healing of aged male rats. Materials and methods Twenty-four Wistar male rats, 20 months old, underwent surgical procedures for the extraction of the upper right incisor and were divided into two groups according to the treatment: Control (C) – intravenous (IV) 0.9% saline, ZL – 0.035 mg/kg of IV zoledronic acid, both every 15 days. At the fifth dose of both substances, tooth extractions were performed and the animals were euthanized after 14 and 28 days. Results IV administration of ZL caused OPG-RANKL system imbalance, resulting in deficient bone formation and remodeling and alteration of osteoclast morphology, as well as maintaining persistent inflammation during the healing period. Conclusions IV administration of ZL delayed extracted dental socket healing of aged rats, but not enough to cause osteonecrosis, raising a question about different responses to IV BP therapy considering animal age. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-01 2018-12-11T17:31:48Z 2018-12-11T17:31:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jcms.2017.02.002 Journal of Cranio-Maxillofacial Surgery, v. 45, n. 5, p. 781-787, 2017. 1878-4119 1010-5182 http://hdl.handle.net/11449/178717 10.1016/j.jcms.2017.02.002 2-s2.0-85015344485 2-s2.0-85015344485.pdf 8621510886887389 |
url |
http://dx.doi.org/10.1016/j.jcms.2017.02.002 http://hdl.handle.net/11449/178717 |
identifier_str_mv |
Journal of Cranio-Maxillofacial Surgery, v. 45, n. 5, p. 781-787, 2017. 1878-4119 1010-5182 10.1016/j.jcms.2017.02.002 2-s2.0-85015344485 2-s2.0-85015344485.pdf 8621510886887389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Cranio-Maxillofacial Surgery 1,033 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
781-787 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128949542191104 |