Human rabies post-exposure prophylaxis relative to the disease epidemiological status

• Autor(a) principal: Martins da Costa Andrade, Bruno Fonseca [UNESP]
• Data de Publicação: 2019
• Outros Autores: Melo Andrade, Taisa Santos de, Queiroz, Luzia Helena [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1413-81232018241.32832016; http://hdl.handle.net/11449/186600
• topic: Rabies; Animal aggression; Post-exposure prophylaxis; Immunization schedule; Dogs

This study evaluated the prophylactic measures adopted after attacks by dogs and cats in the main city of Northwester Sao Paulo State, based on the technical manual for post-exposure treatment, considering the not controlled (19901996) and controlled (1997-2010) rabies status. A retrospective analysis was done using the data from the SINAN records (W64-CID10) between 1990 and 2010. In most cases, the accidents were mild (76.9%), and biting animals were healthy (75.4%); therefore, no treatment was needed in 53.3% of the cases. In 64.6% of cases, the prescribed PEP treatment was inappropriate. The most indicated PEP treatments consisted of vaccine and RIG (43.4%), and either three doses of mouse brain vaccine or two doses of cell culture vaccine (76.5%), during the not controlled and controlled rabies periods, respectively. The treatment was more appropriate and followed the technical recommendations during controlled rabies periods compared to not controlled (p < 0.0001) periods. However, excessive application of RIG and rabies vaccine was observed in both periods.