Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1248/bpb.30.375 http://hdl.handle.net/11449/34195 |
Resumo: | The effects of acute oral administration of erythrinian alkaloids, Le. (+)-alpha-hydroxy-erysotrine, erythravine and (+)-11 alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu were investigated in two animal models of anxiety in mice-the light-dark transition model (LDTM) and the elevated plus-maze (EPM). In the LDTM, erythravine (3, 10 mg/kg) and (+)-11 alpha-hydroxy-erythravine (10mg/kg) increased the time spent by the animals in the illuminated compartment and (+)-11 alpha-hydroxy-erythravine (3 mg/kg) increased the number of transitions between compartments of the LDTM, suggesting an anxiolytic-like effect of these erythrinian alkaloids. Nevertheless, the third alkaloid studied, (+)-alpha-hydroxy-erysotrine, did not change any behavioral response with the range of doses used (3-10 mg/kg). Since the oral administration of the crude extract of E. mulungu (EM) (100-400 mg/kg) did not modify the conventional measures of anxiety in the EPM, this animal model was not chosen to evaluate the anxiolytic properties of the isolated alkaloids. These results suggest that the alkaloids erythravine and (+)-11 alpha-hydroxy-erythravine are responsible for the anxiolytic effects of the crude extract of E. mulungu. |
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Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxietyErythrina mulungualkaloidanxietymedicinal plantcentral nervous systemanimal modelThe effects of acute oral administration of erythrinian alkaloids, Le. (+)-alpha-hydroxy-erysotrine, erythravine and (+)-11 alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu were investigated in two animal models of anxiety in mice-the light-dark transition model (LDTM) and the elevated plus-maze (EPM). In the LDTM, erythravine (3, 10 mg/kg) and (+)-11 alpha-hydroxy-erythravine (10mg/kg) increased the time spent by the animals in the illuminated compartment and (+)-11 alpha-hydroxy-erythravine (3 mg/kg) increased the number of transitions between compartments of the LDTM, suggesting an anxiolytic-like effect of these erythrinian alkaloids. Nevertheless, the third alkaloid studied, (+)-alpha-hydroxy-erysotrine, did not change any behavioral response with the range of doses used (3-10 mg/kg). Since the oral administration of the crude extract of E. mulungu (EM) (100-400 mg/kg) did not modify the conventional measures of anxiety in the EPM, this animal model was not chosen to evaluate the anxiolytic properties of the isolated alkaloids. These results suggest that the alkaloids erythravine and (+)-11 alpha-hydroxy-erythravine are responsible for the anxiolytic effects of the crude extract of E. mulungu.São Paulo State Univ, Pharmacol Lab, BR-14801902 Araraquara, SP, BrazilSão Paulo State Univ, Dept Organ Chem, BR-14801902 Araraquara, SP, BrazilUniv Ribeirao Preto, Dept Vegetal Biotechnol, BR-14096380 Ribeirao Preto, BrazilUniv São Paulo, FFCLRP, Dept Psychobiol, BR-14040901 Ribeirao Preto, SP, BrazilSão Paulo State Univ, Pharmacol Lab, BR-14801902 Araraquara, SP, BrazilSão Paulo State Univ, Dept Organ Chem, BR-14801902 Araraquara, SP, BrazilPharmaceutical Soc JapanUniversidade Estadual Paulista (Unesp)Univ Ribeirao PretoUniversidade de São Paulo (USP)Flausino, Otavio AparecidoPereira, Ana MariaBolzani, Vanderlan da Silva [UNESP]Nunes-de-Souza, Ricardo Luiz2014-05-20T15:23:24Z2014-05-20T15:23:24Z2007-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article375-378application/pdfhttp://dx.doi.org/10.1248/bpb.30.375Biological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 2, p. 375-378, 2007.0918-6158http://hdl.handle.net/11449/3419510.1248/bpb.30.375WOS:0002455826000322-s2.0-33846988259WOS000245582600032.pdf4484083685251673Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiological & Pharmaceutical Bulletin1.6940,626info:eu-repo/semantics/openAccess2023-12-24T06:15:46Zoai:repositorio.unesp.br:11449/34195Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:09:39.155758Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
title |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
spellingShingle |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety Flausino, Otavio Aparecido Erythrina mulungu alkaloid anxiety medicinal plant central nervous system animal model |
title_short |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
title_full |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
title_fullStr |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
title_full_unstemmed |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
title_sort |
Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety |
author |
Flausino, Otavio Aparecido |
author_facet |
Flausino, Otavio Aparecido Pereira, Ana Maria Bolzani, Vanderlan da Silva [UNESP] Nunes-de-Souza, Ricardo Luiz |
author_role |
author |
author2 |
Pereira, Ana Maria Bolzani, Vanderlan da Silva [UNESP] Nunes-de-Souza, Ricardo Luiz |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Ribeirao Preto Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Flausino, Otavio Aparecido Pereira, Ana Maria Bolzani, Vanderlan da Silva [UNESP] Nunes-de-Souza, Ricardo Luiz |
dc.subject.por.fl_str_mv |
Erythrina mulungu alkaloid anxiety medicinal plant central nervous system animal model |
topic |
Erythrina mulungu alkaloid anxiety medicinal plant central nervous system animal model |
description |
The effects of acute oral administration of erythrinian alkaloids, Le. (+)-alpha-hydroxy-erysotrine, erythravine and (+)-11 alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu were investigated in two animal models of anxiety in mice-the light-dark transition model (LDTM) and the elevated plus-maze (EPM). In the LDTM, erythravine (3, 10 mg/kg) and (+)-11 alpha-hydroxy-erythravine (10mg/kg) increased the time spent by the animals in the illuminated compartment and (+)-11 alpha-hydroxy-erythravine (3 mg/kg) increased the number of transitions between compartments of the LDTM, suggesting an anxiolytic-like effect of these erythrinian alkaloids. Nevertheless, the third alkaloid studied, (+)-alpha-hydroxy-erysotrine, did not change any behavioral response with the range of doses used (3-10 mg/kg). Since the oral administration of the crude extract of E. mulungu (EM) (100-400 mg/kg) did not modify the conventional measures of anxiety in the EPM, this animal model was not chosen to evaluate the anxiolytic properties of the isolated alkaloids. These results suggest that the alkaloids erythravine and (+)-11 alpha-hydroxy-erythravine are responsible for the anxiolytic effects of the crude extract of E. mulungu. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-02-01 2014-05-20T15:23:24Z 2014-05-20T15:23:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1248/bpb.30.375 Biological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 2, p. 375-378, 2007. 0918-6158 http://hdl.handle.net/11449/34195 10.1248/bpb.30.375 WOS:000245582600032 2-s2.0-33846988259 WOS000245582600032.pdf 4484083685251673 |
url |
http://dx.doi.org/10.1248/bpb.30.375 http://hdl.handle.net/11449/34195 |
identifier_str_mv |
Biological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 2, p. 375-378, 2007. 0918-6158 10.1248/bpb.30.375 WOS:000245582600032 2-s2.0-33846988259 WOS000245582600032.pdf 4484083685251673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biological & Pharmaceutical Bulletin 1.694 0,626 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
375-378 application/pdf |
dc.publisher.none.fl_str_mv |
Pharmaceutical Soc Japan |
publisher.none.fl_str_mv |
Pharmaceutical Soc Japan |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129291989286912 |