Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/tox.23085 http://hdl.handle.net/11449/206999 |
Resumo: | Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 μg/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 μg/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses. |
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Repositório Institucional da UNESP |
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Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in ratsorganogenesispolycyclic aromatic hydrocarbonratsskeletal abnormalitiesteratogenicityStudies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 μg/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 μg/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)Embrapa EnvironmentCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)Department of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)Center of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)FAPESP: #2018/07394-8FAPESP: #2018/07967-8Universidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)da Silva Moreira, Suyane [UNESP]de Lima Inocêncio, Leonardo Cesar [UNESP]Jorge, Bárbara Campos [UNESP]Reis, Ana Carolina Casali [UNESP]Hisano, HamiltonArena, Arielle Cristina [UNESP]2021-06-25T10:47:23Z2021-06-25T10:47:23Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article831-839http://dx.doi.org/10.1002/tox.23085Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021.1522-72781520-4081http://hdl.handle.net/11449/20699910.1002/tox.230852-s2.0-85097864216Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Toxicologyinfo:eu-repo/semantics/openAccess2024-04-10T18:10:59Zoai:repositorio.unesp.br:11449/206999Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:45:39.771105Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
title |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
spellingShingle |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats da Silva Moreira, Suyane [UNESP] organogenesis polycyclic aromatic hydrocarbon rats skeletal abnormalities teratogenicity |
title_short |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
title_full |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
title_fullStr |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
title_full_unstemmed |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
title_sort |
Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats |
author |
da Silva Moreira, Suyane [UNESP] |
author_facet |
da Silva Moreira, Suyane [UNESP] de Lima Inocêncio, Leonardo Cesar [UNESP] Jorge, Bárbara Campos [UNESP] Reis, Ana Carolina Casali [UNESP] Hisano, Hamilton Arena, Arielle Cristina [UNESP] |
author_role |
author |
author2 |
de Lima Inocêncio, Leonardo Cesar [UNESP] Jorge, Bárbara Campos [UNESP] Reis, Ana Carolina Casali [UNESP] Hisano, Hamilton Arena, Arielle Cristina [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.contributor.author.fl_str_mv |
da Silva Moreira, Suyane [UNESP] de Lima Inocêncio, Leonardo Cesar [UNESP] Jorge, Bárbara Campos [UNESP] Reis, Ana Carolina Casali [UNESP] Hisano, Hamilton Arena, Arielle Cristina [UNESP] |
dc.subject.por.fl_str_mv |
organogenesis polycyclic aromatic hydrocarbon rats skeletal abnormalities teratogenicity |
topic |
organogenesis polycyclic aromatic hydrocarbon rats skeletal abnormalities teratogenicity |
description |
Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 μg/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 μg/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:47:23Z 2021-06-25T10:47:23Z 2021-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/tox.23085 Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021. 1522-7278 1520-4081 http://hdl.handle.net/11449/206999 10.1002/tox.23085 2-s2.0-85097864216 |
url |
http://dx.doi.org/10.1002/tox.23085 http://hdl.handle.net/11449/206999 |
identifier_str_mv |
Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021. 1522-7278 1520-4081 10.1002/tox.23085 2-s2.0-85097864216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
831-839 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129460731379712 |