Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence

Detalhes bibliográficos
Autor(a) principal: Duarte, Josiane O. [UNESP]
Data de Publicação: 2023
Outros Autores: Planeta, Cleopatra S. [UNESP], Crestani, Carlos C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.lfs.2023.121473
http://hdl.handle.net/11449/248516
Resumo: Aims: This study investigated the influence of exposure to stress during adolescence in autonomic, cardiovascular, neuroendocrine and somatic changes evoked by chronic stress in adult rats. Main methods: Animals were subjected to a 10-days protocol of repeated restraint stress (RRS, habituating) or chronic variable stress (CVS, non-habituating) during adolescence, adulthood, or repeated exposure to either RRS or CVS in adolescence and adulthood (adolescence+adulthood group). The trials to measure autonomic, cardiovascular, neuroendocrine and somatic changes in all experimental groups were performed in adulthood. Key findings: CVS increased basal circulating corticosterone levels and caused adrenal hypertrophy in the adolescence+adulthood group, an effect not identified in animals subjected to this stressor only in adulthood or adolescence. CVS also caused a sympathetically-mediated resting tachycardia in the adulthood group. This effect of CVS was not identified in the adolescence+adulthood group once the increased cardiac sympathetic activity was buffered by a decrease in intrinsic heart rate in these animals. Moreover, the impairment in baroreflex function observed in the adulthood group subjected to CVS was shifted to an improvement in animals subjected to repeated exposure to this stressor during adolescence and adulthood. The RRS in the adolescence+adulthood group caused a sympathetically-mediated resting tachycardia, which was not observed in the adulthood group. Significance: Our findings suggest that enduring effects of adverse events during adolescence included a vulnerability to neuroendocrine changes and a resilience to autonomic and cardiovascular dysfunctions caused by the CVS. Furthermore, results of RRS indicated a vulnerability to cardiovascular and autonomic changes evoked by homotypic stressors.
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spelling Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescenceBaroreflexHPA axisRestraintSympathetic activityUnpredictable stressVascular reactivityAims: This study investigated the influence of exposure to stress during adolescence in autonomic, cardiovascular, neuroendocrine and somatic changes evoked by chronic stress in adult rats. Main methods: Animals were subjected to a 10-days protocol of repeated restraint stress (RRS, habituating) or chronic variable stress (CVS, non-habituating) during adolescence, adulthood, or repeated exposure to either RRS or CVS in adolescence and adulthood (adolescence+adulthood group). The trials to measure autonomic, cardiovascular, neuroendocrine and somatic changes in all experimental groups were performed in adulthood. Key findings: CVS increased basal circulating corticosterone levels and caused adrenal hypertrophy in the adolescence+adulthood group, an effect not identified in animals subjected to this stressor only in adulthood or adolescence. CVS also caused a sympathetically-mediated resting tachycardia in the adulthood group. This effect of CVS was not identified in the adolescence+adulthood group once the increased cardiac sympathetic activity was buffered by a decrease in intrinsic heart rate in these animals. Moreover, the impairment in baroreflex function observed in the adulthood group subjected to CVS was shifted to an improvement in animals subjected to repeated exposure to this stressor during adolescence and adulthood. The RRS in the adolescence+adulthood group caused a sympathetically-mediated resting tachycardia, which was not observed in the adulthood group. Significance: Our findings suggest that enduring effects of adverse events during adolescence included a vulnerability to neuroendocrine changes and a resilience to autonomic and cardiovascular dysfunctions caused by the CVS. Furthermore, results of RRS indicated a vulnerability to cardiovascular and autonomic changes evoked by homotypic stressors.Laboratory of Pharmacology Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), São PauloLaboratory of Pharmacology Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), São PauloUniversidade Estadual Paulista (UNESP)Duarte, Josiane O. [UNESP]Planeta, Cleopatra S. [UNESP]Crestani, Carlos C. [UNESP]2023-07-29T13:46:08Z2023-07-29T13:46:08Z2023-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.lfs.2023.121473Life Sciences, v. 318.1879-06310024-3205http://hdl.handle.net/11449/24851610.1016/j.lfs.2023.1214732-s2.0-85149999598Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2024-06-24T13:45:39Zoai:repositorio.unesp.br:11449/248516Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:59:10.465763Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
title Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
spellingShingle Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
Duarte, Josiane O. [UNESP]
Baroreflex
HPA axis
Restraint
Sympathetic activity
Unpredictable stress
Vascular reactivity
title_short Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
title_full Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
title_fullStr Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
title_full_unstemmed Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
title_sort Vulnerability and resilience to cardiovascular and neuroendocrine effects of stress in adult rats with historical of chronic stress during adolescence
author Duarte, Josiane O. [UNESP]
author_facet Duarte, Josiane O. [UNESP]
Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
author_role author
author2 Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Duarte, Josiane O. [UNESP]
Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
dc.subject.por.fl_str_mv Baroreflex
HPA axis
Restraint
Sympathetic activity
Unpredictable stress
Vascular reactivity
topic Baroreflex
HPA axis
Restraint
Sympathetic activity
Unpredictable stress
Vascular reactivity
description Aims: This study investigated the influence of exposure to stress during adolescence in autonomic, cardiovascular, neuroendocrine and somatic changes evoked by chronic stress in adult rats. Main methods: Animals were subjected to a 10-days protocol of repeated restraint stress (RRS, habituating) or chronic variable stress (CVS, non-habituating) during adolescence, adulthood, or repeated exposure to either RRS or CVS in adolescence and adulthood (adolescence+adulthood group). The trials to measure autonomic, cardiovascular, neuroendocrine and somatic changes in all experimental groups were performed in adulthood. Key findings: CVS increased basal circulating corticosterone levels and caused adrenal hypertrophy in the adolescence+adulthood group, an effect not identified in animals subjected to this stressor only in adulthood or adolescence. CVS also caused a sympathetically-mediated resting tachycardia in the adulthood group. This effect of CVS was not identified in the adolescence+adulthood group once the increased cardiac sympathetic activity was buffered by a decrease in intrinsic heart rate in these animals. Moreover, the impairment in baroreflex function observed in the adulthood group subjected to CVS was shifted to an improvement in animals subjected to repeated exposure to this stressor during adolescence and adulthood. The RRS in the adolescence+adulthood group caused a sympathetically-mediated resting tachycardia, which was not observed in the adulthood group. Significance: Our findings suggest that enduring effects of adverse events during adolescence included a vulnerability to neuroendocrine changes and a resilience to autonomic and cardiovascular dysfunctions caused by the CVS. Furthermore, results of RRS indicated a vulnerability to cardiovascular and autonomic changes evoked by homotypic stressors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:46:08Z
2023-07-29T13:46:08Z
2023-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.lfs.2023.121473
Life Sciences, v. 318.
1879-0631
0024-3205
http://hdl.handle.net/11449/248516
10.1016/j.lfs.2023.121473
2-s2.0-85149999598
url http://dx.doi.org/10.1016/j.lfs.2023.121473
http://hdl.handle.net/11449/248516
identifier_str_mv Life Sciences, v. 318.
1879-0631
0024-3205
10.1016/j.lfs.2023.121473
2-s2.0-85149999598
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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