Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women

Detalhes bibliográficos
Autor(a) principal: De Carvalho, Flavia Giolo
Data de Publicação: 2021
Outros Autores: Brandao, Camila Fernanda Cunha, Muñoz, Vitor Rosetto, Batitucci, Gabriela [UNESP], Tavares, Maria Eduarda de Almeida [UNESP], Teixeira, Giovana Rampazzo [UNESP], Pauli, José Rodrigo, De Moura, Leandro Pereira, Ropelle, Eduardo Rochete, Cintra, Dennys Esper, da Silva, Adelino Sanchez Ramos, Junqueira‐Franco, Márcia Varella Morandi, Marchini, Julio Sergio, De Freitas, Ellen Cristini [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00726-021-03041-4
http://hdl.handle.net/11449/229134
Resumo: Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019.
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spelling Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese womenAdipocyte plasticityAdipose tissueInflammationObesityTaurineInterventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Physical Education and Sport of Ribeirão Preto University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte AlegreInternal Medicine Department Ribeirão Preto Medical School University of São Paulo-FMRP USPState University of Minas Gerais - UEMG, Divinopolis unitLaboratory of Molecular Biology of Exercise University of Campinas-FCA UNICAMPDepartment of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESPDepartment of Physical Education School of Technology and Science São Paulo State University-UNESPLaboratory of Nutritional Genomics University of Campinas-FCA UNICAMPDepartment of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESPDepartment of Physical Education School of Technology and Science São Paulo State University-UNESPFAPESP: 2017/08036-5FAPESP: 2017/10080-2Universidade de São Paulo (USP)Universidade Estadual de Maringá (UEM)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)De Carvalho, Flavia GioloBrandao, Camila Fernanda CunhaMuñoz, Vitor RosettoBatitucci, Gabriela [UNESP]Tavares, Maria Eduarda de Almeida [UNESP]Teixeira, Giovana Rampazzo [UNESP]Pauli, José RodrigoDe Moura, Leandro PereiraRopelle, Eduardo RocheteCintra, Dennys Esperda Silva, Adelino Sanchez RamosJunqueira‐Franco, Márcia Varella MorandiMarchini, Julio SergioDe Freitas, Ellen Cristini [UNESP]2022-04-29T08:30:40Z2022-04-29T08:30:40Z2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1391-1403http://dx.doi.org/10.1007/s00726-021-03041-4Amino Acids, v. 53, n. 9, p. 1391-1403, 2021.1438-21990939-4451http://hdl.handle.net/11449/22913410.1007/s00726-021-03041-42-s2.0-85109976007Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmino Acidsinfo:eu-repo/semantics/openAccess2024-06-21T12:46:37Zoai:repositorio.unesp.br:11449/229134Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:40:42.223037Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
title Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
spellingShingle Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
De Carvalho, Flavia Giolo
Adipocyte plasticity
Adipose tissue
Inflammation
Obesity
Taurine
title_short Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
title_full Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
title_fullStr Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
title_full_unstemmed Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
title_sort Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
author De Carvalho, Flavia Giolo
author_facet De Carvalho, Flavia Giolo
Brandao, Camila Fernanda Cunha
Muñoz, Vitor Rosetto
Batitucci, Gabriela [UNESP]
Tavares, Maria Eduarda de Almeida [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Pauli, José Rodrigo
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Cintra, Dennys Esper
da Silva, Adelino Sanchez Ramos
Junqueira‐Franco, Márcia Varella Morandi
Marchini, Julio Sergio
De Freitas, Ellen Cristini [UNESP]
author_role author
author2 Brandao, Camila Fernanda Cunha
Muñoz, Vitor Rosetto
Batitucci, Gabriela [UNESP]
Tavares, Maria Eduarda de Almeida [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Pauli, José Rodrigo
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Cintra, Dennys Esper
da Silva, Adelino Sanchez Ramos
Junqueira‐Franco, Márcia Varella Morandi
Marchini, Julio Sergio
De Freitas, Ellen Cristini [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual de Maringá (UEM)
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv De Carvalho, Flavia Giolo
Brandao, Camila Fernanda Cunha
Muñoz, Vitor Rosetto
Batitucci, Gabriela [UNESP]
Tavares, Maria Eduarda de Almeida [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Pauli, José Rodrigo
De Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Cintra, Dennys Esper
da Silva, Adelino Sanchez Ramos
Junqueira‐Franco, Márcia Varella Morandi
Marchini, Julio Sergio
De Freitas, Ellen Cristini [UNESP]
dc.subject.por.fl_str_mv Adipocyte plasticity
Adipose tissue
Inflammation
Obesity
Taurine
topic Adipocyte plasticity
Adipose tissue
Inflammation
Obesity
Taurine
description Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
2022-04-29T08:30:40Z
2022-04-29T08:30:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00726-021-03041-4
Amino Acids, v. 53, n. 9, p. 1391-1403, 2021.
1438-2199
0939-4451
http://hdl.handle.net/11449/229134
10.1007/s00726-021-03041-4
2-s2.0-85109976007
url http://dx.doi.org/10.1007/s00726-021-03041-4
http://hdl.handle.net/11449/229134
identifier_str_mv Amino Acids, v. 53, n. 9, p. 1391-1403, 2021.
1438-2199
0939-4451
10.1007/s00726-021-03041-4
2-s2.0-85109976007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amino Acids
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1391-1403
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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