Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fnbeh.2022.835717 http://hdl.handle.net/11449/240002 |
Resumo: | Recognizing and sharing emotions are essential for species survival, but in some cases, living with a conspecific in distress condition may induce negative emotional states through empathy-like processes. Studies have reported that stressors promote psychiatric disorders in both, those who suffer directly and who witness these aversive episodes, principally whether social proximity is involved. However, the mechanisms underlying the harmful outcomes of emotional contagion need more studies, mainly in the drug addiction-related behaviors. Here, we investigated the relevance of familiarity and the effects of cohabitation with a partner submitted to chronic stress in the anxiety-like, locomotor sensitization, and consolation behaviors. Male Swiss mice were housed in pairs during different periods to test the establishment of familiarity and the stress-induced anxiety behavior in the elevated plus maze. Another cohort was housed with a conspecific subjected to repeated restraint stress (1 h/day) for 14 days. During chronic restraint the allogrooming was measured and after the stress period mice were tested in the open field for evaluation of anxiety and locomotor cross-sensitization induced by methamphetamine. We found that familiarity was established after 14 days of cohabitation and the anxiogenic behavior appeared after 14 days of stress. Repeated restraint stress also increased anxiety in the open field test and induced locomotor cross-sensitization in the stressed mice and their cagemates. Cagemates also exhibited an increase in the consolation behavior after stress sessions when compared to control mice. These results indicate that changes in drug abuse-related, consolation, and affective behaviors may be precipitated through emotional contagion in familiar conspecifics. |
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Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavioranxietyconsolationcross-sensitizationemotional contagionfamiliaritymethamphetaminemicerestraint stressRecognizing and sharing emotions are essential for species survival, but in some cases, living with a conspecific in distress condition may induce negative emotional states through empathy-like processes. Studies have reported that stressors promote psychiatric disorders in both, those who suffer directly and who witness these aversive episodes, principally whether social proximity is involved. However, the mechanisms underlying the harmful outcomes of emotional contagion need more studies, mainly in the drug addiction-related behaviors. Here, we investigated the relevance of familiarity and the effects of cohabitation with a partner submitted to chronic stress in the anxiety-like, locomotor sensitization, and consolation behaviors. Male Swiss mice were housed in pairs during different periods to test the establishment of familiarity and the stress-induced anxiety behavior in the elevated plus maze. Another cohort was housed with a conspecific subjected to repeated restraint stress (1 h/day) for 14 days. During chronic restraint the allogrooming was measured and after the stress period mice were tested in the open field for evaluation of anxiety and locomotor cross-sensitization induced by methamphetamine. We found that familiarity was established after 14 days of cohabitation and the anxiogenic behavior appeared after 14 days of stress. Repeated restraint stress also increased anxiety in the open field test and induced locomotor cross-sensitization in the stressed mice and their cagemates. Cagemates also exhibited an increase in the consolation behavior after stress sessions when compared to control mice. These results indicate that changes in drug abuse-related, consolation, and affective behaviors may be precipitated through emotional contagion in familiar conspecifics.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Psychobiology Group Department of Psychology/CECH Federal University of São CarlosJoint Graduate Program in Physiological Sciences UFSCar/UNESP Federal University of São CarlosGraduate Program in Psychology Federal University of São CarlosNeuroscience and Behavioral InstituteJoint Graduate Program in Physiological Sciences UFSCar/UNESP Federal University of São CarlosUniversidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Neuroscience and Behavioral InstituteOliveira, Paulo Eduardo Carneiro deCarmona, Isabela Miranda [UNESP]Casarotto, MarianaSilveira, Lara MariaOliveira, Anna Cecília Bezerra [UNESP]Canto-de-Souza, Azair [UNESP]2023-03-01T19:57:05Z2023-03-01T19:57:05Z2022-04-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fnbeh.2022.835717Frontiers in Behavioral Neuroscience, v. 16.1662-5153http://hdl.handle.net/11449/24000210.3389/fnbeh.2022.8357172-s2.0-85129492743Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Behavioral Neuroscienceinfo:eu-repo/semantics/openAccess2023-03-01T19:57:05Zoai:repositorio.unesp.br:11449/240002Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:34:40.596700Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
title |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
spellingShingle |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior Oliveira, Paulo Eduardo Carneiro de anxiety consolation cross-sensitization emotional contagion familiarity methamphetamine mice restraint stress |
title_short |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
title_full |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
title_fullStr |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
title_full_unstemmed |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
title_sort |
Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior |
author |
Oliveira, Paulo Eduardo Carneiro de |
author_facet |
Oliveira, Paulo Eduardo Carneiro de Carmona, Isabela Miranda [UNESP] Casarotto, Mariana Silveira, Lara Maria Oliveira, Anna Cecília Bezerra [UNESP] Canto-de-Souza, Azair [UNESP] |
author_role |
author |
author2 |
Carmona, Isabela Miranda [UNESP] Casarotto, Mariana Silveira, Lara Maria Oliveira, Anna Cecília Bezerra [UNESP] Canto-de-Souza, Azair [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (UNESP) Neuroscience and Behavioral Institute |
dc.contributor.author.fl_str_mv |
Oliveira, Paulo Eduardo Carneiro de Carmona, Isabela Miranda [UNESP] Casarotto, Mariana Silveira, Lara Maria Oliveira, Anna Cecília Bezerra [UNESP] Canto-de-Souza, Azair [UNESP] |
dc.subject.por.fl_str_mv |
anxiety consolation cross-sensitization emotional contagion familiarity methamphetamine mice restraint stress |
topic |
anxiety consolation cross-sensitization emotional contagion familiarity methamphetamine mice restraint stress |
description |
Recognizing and sharing emotions are essential for species survival, but in some cases, living with a conspecific in distress condition may induce negative emotional states through empathy-like processes. Studies have reported that stressors promote psychiatric disorders in both, those who suffer directly and who witness these aversive episodes, principally whether social proximity is involved. However, the mechanisms underlying the harmful outcomes of emotional contagion need more studies, mainly in the drug addiction-related behaviors. Here, we investigated the relevance of familiarity and the effects of cohabitation with a partner submitted to chronic stress in the anxiety-like, locomotor sensitization, and consolation behaviors. Male Swiss mice were housed in pairs during different periods to test the establishment of familiarity and the stress-induced anxiety behavior in the elevated plus maze. Another cohort was housed with a conspecific subjected to repeated restraint stress (1 h/day) for 14 days. During chronic restraint the allogrooming was measured and after the stress period mice were tested in the open field for evaluation of anxiety and locomotor cross-sensitization induced by methamphetamine. We found that familiarity was established after 14 days of cohabitation and the anxiogenic behavior appeared after 14 days of stress. Repeated restraint stress also increased anxiety in the open field test and induced locomotor cross-sensitization in the stressed mice and their cagemates. Cagemates also exhibited an increase in the consolation behavior after stress sessions when compared to control mice. These results indicate that changes in drug abuse-related, consolation, and affective behaviors may be precipitated through emotional contagion in familiar conspecifics. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-18 2023-03-01T19:57:05Z 2023-03-01T19:57:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fnbeh.2022.835717 Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 http://hdl.handle.net/11449/240002 10.3389/fnbeh.2022.835717 2-s2.0-85129492743 |
url |
http://dx.doi.org/10.3389/fnbeh.2022.835717 http://hdl.handle.net/11449/240002 |
identifier_str_mv |
Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 10.3389/fnbeh.2022.835717 2-s2.0-85129492743 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Behavioral Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129440179290112 |