Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-86502014000100006 http://hdl.handle.net/11449/112476 |
Resumo: | PURPOSE: To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.METHODS: Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic.RESULTS: A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose.CONCLUSION: Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs. |
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Repositório Institucional da UNESP |
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Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogsAnesthesiaepiduralNalbuphineIsofluraneDogPURPOSE: To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.METHODS: Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic.RESULTS: A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose.CONCLUSION: Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.Fed Univ Mato Grosso Sul UFMS, Fac Vet Med & Anim Sci, Dept Vet Med Surg & Anesthesiol, Campo Grande, MS, BrazilUniv Fed Mato Grosso do Sul, Fac Vet Med & Anim Sci, Dept Vet Med Surg & Anesthesiol, Campo Grande, MS, BrazilUniv Fed Mato Grosso do Sul, Fac Vet Med & Anim Sci, Lab Small Anim Surg & Anesthesiol, Campo Grande, MS, BrazilUniv Fed Mato Grosso do Sul, Fac Vet Med & Anim Sci, Lab Small Anim Clin, Campo Grande, MS, BrazilUniv Sao Paulo, Sch Med, Postgrad Anesthesiol, BR-05508 Sao Paulo, BrazilSao Paulo State Univ UNESP, Sch Agrarian & Vet Sci, Program Vet Surg, Jaboticabal, SP, BrazilSao Paulo State Univ UNESP, Sch Agrarian & Vet Sci, Program Vet Surg, Jaboticabal, SP, BrazilActa Cirúrgica BrasileiraUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Frazilio, Fabricio de OliveiraDeRossi, RafaelAffonseca Jardim, Paulo Henrique deMarques, Beatriz CandoloCarvalho Martins, Alessandro Rodrigues deHermeto, Larissa Correa [UNESP]2014-12-03T13:10:44Z2014-12-03T13:10:44Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article38-46application/pdfhttp://dx.doi.org/10.1590/S0102-86502014000100006Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, n. 1, p. 38-46, 2014.0102-8650http://hdl.handle.net/11449/112476S0102-86502014000100006WOS:000330868700006S0102-86502014000100006.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirúrgica Brasileira0.9330,395info:eu-repo/semantics/openAccess2023-11-10T06:08:37Zoai:repositorio.unesp.br:11449/112476Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-10T06:08:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
title |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
spellingShingle |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs Frazilio, Fabricio de Oliveira Anesthesia epidural Nalbuphine Isoflurane Dog |
title_short |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
title_full |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
title_fullStr |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
title_full_unstemmed |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
title_sort |
Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs |
author |
Frazilio, Fabricio de Oliveira |
author_facet |
Frazilio, Fabricio de Oliveira DeRossi, Rafael Affonseca Jardim, Paulo Henrique de Marques, Beatriz Candolo Carvalho Martins, Alessandro Rodrigues de Hermeto, Larissa Correa [UNESP] |
author_role |
author |
author2 |
DeRossi, Rafael Affonseca Jardim, Paulo Henrique de Marques, Beatriz Candolo Carvalho Martins, Alessandro Rodrigues de Hermeto, Larissa Correa [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Frazilio, Fabricio de Oliveira DeRossi, Rafael Affonseca Jardim, Paulo Henrique de Marques, Beatriz Candolo Carvalho Martins, Alessandro Rodrigues de Hermeto, Larissa Correa [UNESP] |
dc.subject.por.fl_str_mv |
Anesthesia epidural Nalbuphine Isoflurane Dog |
topic |
Anesthesia epidural Nalbuphine Isoflurane Dog |
description |
PURPOSE: To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.METHODS: Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic.RESULTS: A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose.CONCLUSION: Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:10:44Z 2014-12-03T13:10:44Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502014000100006 Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, n. 1, p. 38-46, 2014. 0102-8650 http://hdl.handle.net/11449/112476 S0102-86502014000100006 WOS:000330868700006 S0102-86502014000100006.pdf |
url |
http://dx.doi.org/10.1590/S0102-86502014000100006 http://hdl.handle.net/11449/112476 |
identifier_str_mv |
Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, n. 1, p. 38-46, 2014. 0102-8650 S0102-86502014000100006 WOS:000330868700006 S0102-86502014000100006.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirúrgica Brasileira 0.933 0,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
38-46 application/pdf |
dc.publisher.none.fl_str_mv |
Acta Cirúrgica Brasileira |
publisher.none.fl_str_mv |
Acta Cirúrgica Brasileira |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1792961781241479168 |