Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1055/a-1301-0183 http://hdl.handle.net/11449/207027 |
Resumo: | Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4? Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3- O-α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation (R 2= 0.3?-?0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines. |
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Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomesbiological activitiesCasearia sylvestrisclerodane diterpenoidsglycosylated flavonoidsmetabolomicsmultivariate data analysisplant ecophysiologySalicaceaeCasearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4? Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3- O-α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation (R 2= 0.3?-?0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines.Institute of Chemistry Department of Biochemistry and Organic Chemistry São Paulo State University (UNESP), CEP 14800-060, Rua Prof. Francisco Degni 55Natural Products Laboratory Institute of Biology Leiden UniversityNatl. Inst. of Alternative Technol. for Detection Toxicological Assess. Removal of Micropollutants and Radioactive Substances AraraquaraAgronomic Institute of Campinas Herbarium IACDepartment of Biophysics and Physiology Laboratory of Experimental Cancerology Federal University of PiauíDepartment of Physiology and Pharmacology Faculty of Medicine Federal University of CearáInstitute of Chemistry Department of Biochemistry and Organic Chemistry São Paulo State University (UNESP), CEP 14800-060, Rua Prof. Francisco Degni 55Universidade Estadual Paulista (Unesp)Leiden UniversityRemoval of Micropollutants and Radioactive Substances AraraquaraHerbarium IACFederal University of PiauíFederal University of CearáBueno, Paula Carolina Pires [UNESP]Abarca, Luis Francisco SaloméAnhesine, Naira Buzzo [UNESP]Giffoni, Maíra Silva [UNESP]Pereira, Fabiola Manhas Verbi [UNESP]Torres, Roseli BuzaneliDe, Rayran Walter RamossousaFerreira, Paulo Michel PinheiroPessoa, ClaudiaCavalheiro, Alberto José [UNESP]2021-06-25T10:47:52Z2021-06-25T10:47:52Z2021-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article148-159http://dx.doi.org/10.1055/a-1301-0183Planta Medica, v. 87, n. 1-2, p. 148-159, 2021.1439-02210032-0943http://hdl.handle.net/11449/20702710.1055/a-1301-01832-s2.0-85098258451Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlanta Medicainfo:eu-repo/semantics/openAccess2021-10-23T16:01:03Zoai:repositorio.unesp.br:11449/207027Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:47:00.440113Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
title |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
spellingShingle |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes Bueno, Paula Carolina Pires [UNESP] biological activities Casearia sylvestris clerodane diterpenoids glycosylated flavonoids metabolomics multivariate data analysis plant ecophysiology Salicaceae |
title_short |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
title_full |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
title_fullStr |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
title_full_unstemmed |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
title_sort |
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes |
author |
Bueno, Paula Carolina Pires [UNESP] |
author_facet |
Bueno, Paula Carolina Pires [UNESP] Abarca, Luis Francisco Salomé Anhesine, Naira Buzzo [UNESP] Giffoni, Maíra Silva [UNESP] Pereira, Fabiola Manhas Verbi [UNESP] Torres, Roseli Buzaneli De, Rayran Walter Ramossousa Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Cavalheiro, Alberto José [UNESP] |
author_role |
author |
author2 |
Abarca, Luis Francisco Salomé Anhesine, Naira Buzzo [UNESP] Giffoni, Maíra Silva [UNESP] Pereira, Fabiola Manhas Verbi [UNESP] Torres, Roseli Buzaneli De, Rayran Walter Ramossousa Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Cavalheiro, Alberto José [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Leiden University Removal of Micropollutants and Radioactive Substances Araraquara Herbarium IAC Federal University of Piauí Federal University of Ceará |
dc.contributor.author.fl_str_mv |
Bueno, Paula Carolina Pires [UNESP] Abarca, Luis Francisco Salomé Anhesine, Naira Buzzo [UNESP] Giffoni, Maíra Silva [UNESP] Pereira, Fabiola Manhas Verbi [UNESP] Torres, Roseli Buzaneli De, Rayran Walter Ramossousa Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Cavalheiro, Alberto José [UNESP] |
dc.subject.por.fl_str_mv |
biological activities Casearia sylvestris clerodane diterpenoids glycosylated flavonoids metabolomics multivariate data analysis plant ecophysiology Salicaceae |
topic |
biological activities Casearia sylvestris clerodane diterpenoids glycosylated flavonoids metabolomics multivariate data analysis plant ecophysiology Salicaceae |
description |
Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4? Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3- O-α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation (R 2= 0.3?-?0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:47:52Z 2021-06-25T10:47:52Z 2021-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1055/a-1301-0183 Planta Medica, v. 87, n. 1-2, p. 148-159, 2021. 1439-0221 0032-0943 http://hdl.handle.net/11449/207027 10.1055/a-1301-0183 2-s2.0-85098258451 |
url |
http://dx.doi.org/10.1055/a-1301-0183 http://hdl.handle.net/11449/207027 |
identifier_str_mv |
Planta Medica, v. 87, n. 1-2, p. 148-159, 2021. 1439-0221 0032-0943 10.1055/a-1301-0183 2-s2.0-85098258451 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Planta Medica |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
148-159 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129357724516352 |