Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats.
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1517-74912003000100002 http://hdl.handle.net/11449/67167 |
Resumo: | Neonatal administration of monosodium glutamate (MSG) in rats causes definite neuroendocrine disturbances which lead to alterations in many organ systems. The possibility that MSG could affect tooth and salivary gland physiology was examined in this paper. Male and female pups were injected subcutaneously with MSG (4 mg/g BW) once a day at the 2nd, 4th, 6th, 8th and 10th day after birth. Control animals were injected with saline, following the same schedule. Lower incisor eruption was determined between the 4th and the 10th postnatal days, and the eruption rate was measured between the 43rd and the 67th days of age. Pilocarpine-stimulated salivary flow was measured at 3 months of age; protein and amylase contents were thereby determined. The animals treated with MSG showed significant reductions in the salivary flow (males, -27%; females, -40%) and in the weight of submandibular glands (about -12%). Body weight reduction was only about 7% for males, and did not vary in females. Saliva of MSG-treated rats had increased concentrations of total proteins and amylase activity. The eruption of lower incisors occurred earlier in MSG-treated rats than in the control group, but on the other hand the eruption rate was significantly slowed down. The incisor microhardness was found to be lower than that of control rats. Our results show that neonatal MSG treatment causes well-defined oral disturbances in adulthood in rats, including salivary flow reduction, which coexisted with unaltered protein synthesis, and disturbances of dental mineralization and eruption. These data support the view that some MSG-sensitive hypothalamic nuclei have an important modulatory effect on the factors which determine caries susceptibility. |
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Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats.amylasefood additiveglutamate sodiumanimalbody weightdrug effectenamelfemalemalemetabolismneurosecretionnewbornratsalivasalivary glandsalivationsex differencetooth eruptionWistar ratAmylasesAnimalsAnimals, NewbornBody WeightDental EnamelFemaleFood AdditivesMaleNeurosecretory SystemsRatsRats, WistarSalivaSalivary GlandsSalivationSex FactorsSodium GlutamateTooth EruptionNeonatal administration of monosodium glutamate (MSG) in rats causes definite neuroendocrine disturbances which lead to alterations in many organ systems. The possibility that MSG could affect tooth and salivary gland physiology was examined in this paper. Male and female pups were injected subcutaneously with MSG (4 mg/g BW) once a day at the 2nd, 4th, 6th, 8th and 10th day after birth. Control animals were injected with saline, following the same schedule. Lower incisor eruption was determined between the 4th and the 10th postnatal days, and the eruption rate was measured between the 43rd and the 67th days of age. Pilocarpine-stimulated salivary flow was measured at 3 months of age; protein and amylase contents were thereby determined. The animals treated with MSG showed significant reductions in the salivary flow (males, -27%; females, -40%) and in the weight of submandibular glands (about -12%). Body weight reduction was only about 7% for males, and did not vary in females. Saliva of MSG-treated rats had increased concentrations of total proteins and amylase activity. The eruption of lower incisors occurred earlier in MSG-treated rats than in the control group, but on the other hand the eruption rate was significantly slowed down. The incisor microhardness was found to be lower than that of control rats. Our results show that neonatal MSG treatment causes well-defined oral disturbances in adulthood in rats, including salivary flow reduction, which coexisted with unaltered protein synthesis, and disturbances of dental mineralization and eruption. These data support the view that some MSG-sensitive hypothalamic nuclei have an important modulatory effect on the factors which determine caries susceptibility.Universidade Estadual Paulista (Unesp)Sassaki, Kikue TakebayashiDelbem, Alberto Carlos Botazzo [UNESP]dos Santos, Otoniel AntonioShimabucoro, Carlos EduardoNakamune, Ana Cláudia de Melo Stevanato [UNESP]Bedran-de-Castro, João CésarOliveira-Filho, Ricardo Martins2014-05-27T11:20:36Z2014-05-27T11:20:36Z2003-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5-10application/pdfhttp://dx.doi.org/10.1590/S1517-74912003000100002Pesquisa odontologica brasileira = Brazilian oral research, v. 17, n. 1, p. 5-10, 2003.1517-7491http://hdl.handle.net/11449/6716710.1590/S1517-74912003000100002S1517-749120030001000022-s2.0-01420580162-s2.0-0142058016.pdf72394710166541330000-0002-8159-4853Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Odontológica Brasileira = Brazilian Oral Research0,505info:eu-repo/semantics/openAccess2023-12-24T06:16:44Zoai:repositorio.unesp.br:11449/67167Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:10:06.973400Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
title |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
spellingShingle |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. Sassaki, Kikue Takebayashi amylase food additive glutamate sodium animal body weight drug effect enamel female male metabolism neurosecretion newborn rat saliva salivary gland salivation sex difference tooth eruption Wistar rat Amylases Animals Animals, Newborn Body Weight Dental Enamel Female Food Additives Male Neurosecretory Systems Rats Rats, Wistar Saliva Salivary Glands Salivation Sex Factors Sodium Glutamate Tooth Eruption |
title_short |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
title_full |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
title_fullStr |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
title_full_unstemmed |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
title_sort |
Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats. |
author |
Sassaki, Kikue Takebayashi |
author_facet |
Sassaki, Kikue Takebayashi Delbem, Alberto Carlos Botazzo [UNESP] dos Santos, Otoniel Antonio Shimabucoro, Carlos Eduardo Nakamune, Ana Cláudia de Melo Stevanato [UNESP] Bedran-de-Castro, João César Oliveira-Filho, Ricardo Martins |
author_role |
author |
author2 |
Delbem, Alberto Carlos Botazzo [UNESP] dos Santos, Otoniel Antonio Shimabucoro, Carlos Eduardo Nakamune, Ana Cláudia de Melo Stevanato [UNESP] Bedran-de-Castro, João César Oliveira-Filho, Ricardo Martins |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sassaki, Kikue Takebayashi Delbem, Alberto Carlos Botazzo [UNESP] dos Santos, Otoniel Antonio Shimabucoro, Carlos Eduardo Nakamune, Ana Cláudia de Melo Stevanato [UNESP] Bedran-de-Castro, João César Oliveira-Filho, Ricardo Martins |
dc.subject.por.fl_str_mv |
amylase food additive glutamate sodium animal body weight drug effect enamel female male metabolism neurosecretion newborn rat saliva salivary gland salivation sex difference tooth eruption Wistar rat Amylases Animals Animals, Newborn Body Weight Dental Enamel Female Food Additives Male Neurosecretory Systems Rats Rats, Wistar Saliva Salivary Glands Salivation Sex Factors Sodium Glutamate Tooth Eruption |
topic |
amylase food additive glutamate sodium animal body weight drug effect enamel female male metabolism neurosecretion newborn rat saliva salivary gland salivation sex difference tooth eruption Wistar rat Amylases Animals Animals, Newborn Body Weight Dental Enamel Female Food Additives Male Neurosecretory Systems Rats Rats, Wistar Saliva Salivary Glands Salivation Sex Factors Sodium Glutamate Tooth Eruption |
description |
Neonatal administration of monosodium glutamate (MSG) in rats causes definite neuroendocrine disturbances which lead to alterations in many organ systems. The possibility that MSG could affect tooth and salivary gland physiology was examined in this paper. Male and female pups were injected subcutaneously with MSG (4 mg/g BW) once a day at the 2nd, 4th, 6th, 8th and 10th day after birth. Control animals were injected with saline, following the same schedule. Lower incisor eruption was determined between the 4th and the 10th postnatal days, and the eruption rate was measured between the 43rd and the 67th days of age. Pilocarpine-stimulated salivary flow was measured at 3 months of age; protein and amylase contents were thereby determined. The animals treated with MSG showed significant reductions in the salivary flow (males, -27%; females, -40%) and in the weight of submandibular glands (about -12%). Body weight reduction was only about 7% for males, and did not vary in females. Saliva of MSG-treated rats had increased concentrations of total proteins and amylase activity. The eruption of lower incisors occurred earlier in MSG-treated rats than in the control group, but on the other hand the eruption rate was significantly slowed down. The incisor microhardness was found to be lower than that of control rats. Our results show that neonatal MSG treatment causes well-defined oral disturbances in adulthood in rats, including salivary flow reduction, which coexisted with unaltered protein synthesis, and disturbances of dental mineralization and eruption. These data support the view that some MSG-sensitive hypothalamic nuclei have an important modulatory effect on the factors which determine caries susceptibility. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-01-01 2014-05-27T11:20:36Z 2014-05-27T11:20:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1517-74912003000100002 Pesquisa odontologica brasileira = Brazilian oral research, v. 17, n. 1, p. 5-10, 2003. 1517-7491 http://hdl.handle.net/11449/67167 10.1590/S1517-74912003000100002 S1517-74912003000100002 2-s2.0-0142058016 2-s2.0-0142058016.pdf 7239471016654133 0000-0002-8159-4853 |
url |
http://dx.doi.org/10.1590/S1517-74912003000100002 http://hdl.handle.net/11449/67167 |
identifier_str_mv |
Pesquisa odontologica brasileira = Brazilian oral research, v. 17, n. 1, p. 5-10, 2003. 1517-7491 10.1590/S1517-74912003000100002 S1517-74912003000100002 2-s2.0-0142058016 2-s2.0-0142058016.pdf 7239471016654133 0000-0002-8159-4853 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Odontológica Brasileira = Brazilian Oral Research 0,505 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5-10 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129292775718912 |