Avaliação histológica do potencial anti-inflamatório do Carvedilol no tecido pulpar de ratos Wistar após clareação dentária

• Autor(a) principal: Louzada, Lidiane Mendes [UNESP]
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/155278; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-05-02/000881372.pdf
• topic: Clareamento dental; Pulpite; Ratos Wistar; Agentes anti-inflamatórios; Antioxidantes; Teeth bleaching

Carvedilol, antioxidant and anti-inflammatory drug, was described by decreasing proinflammatory cytokines in periodontitis. The hydrogen peroxide (H2O2) of bleaching gel generates damage to the pulp ranging from inflammation to necrosis. This study evaluated the antiinflammatory potential of Carvedilol pulp of rat molars after dental bleaching. The molars duty of 28 Wistar rats received Whiteness HP Maxx H2O2 35% (1x30 min), and the left served as the control. Half of the animals received Carvedilol gel (1x10 min), forming groups (n=7): Ble - bleached; Ble+Carv - bleached followed by Carvedilol; Control - no treatment. After 2 and 30 days, the rats were killed for evaluation H.E., and the data subjected to the Kruskal-Wallis test and Dunn (p <0.05). After 2 days, the Ble group showed necrosis in the occlusal third of the coronal pulp in most specimens, and Ble+Carv, severe inflammation (p>0.05), with a difference when compared to control (p<0.05). In the middle third, Ble showed severe inflammation and Ble+Carv, moderate (p>0.05), with only difference between Ble and control (p <0.05). In the cervical third, Ble showed moderate inflammation, and Ble+Carv, mild (p>0.05). The difference remained only between Ble and control (p<0.05). At 30 days, there was no inflammation in all groups (p>0.05), and a marked amount of tertiary dentin in teeth bleached independent application of Carvedilol (p> 0.05). It was found that the gel Carvedilol has the potential of minimizing H2O2 damage, especially in deep regions of dental pulp of Wistar rats after bleaching procedure