Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes

Detalhes bibliográficos
Autor(a) principal: Sangiorgio, João Paulo Menck
Data de Publicação: 2017
Outros Autores: Da Silva Neves, Felipe Lucas, Dos Santos, Manuela Rocha, França-Grohmann, Isabela Lima, Casarin, Renato Corrêa Viana, Casati, Márcio Zaffalon, Santamaria, Mauro Pedrine, Sallum, Enilson Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1902/jop.2017.170126
http://hdl.handle.net/11449/220974
Resumo: Background: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and/or EMD. Methods: Sixty-eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery. Results: The obtained root coverage was 68.04% ± 24.11% for CAF; 87.20% ± 15.01% for CAF + CM; 88.77% ± 20.66% for CAF + EMD; and 91.59% ± 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (P <0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (P <0.05). Keratinized tissue thickness gain was significant only in CM-treated groups (P <0.05). Conclusions: The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.
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spelling Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomesCollagenEnamel matrix proteinsGeneral surgeryGingival recessionSurgery, plasticTooth rootBackground: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and/or EMD. Methods: Sixty-eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery. Results: The obtained root coverage was 68.04% ± 24.11% for CAF; 87.20% ± 15.01% for CAF + CM; 88.77% ± 20.66% for CAF + EMD; and 91.59% ± 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (P <0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (P <0.05). Keratinized tissue thickness gain was significant only in CM-treated groups (P <0.05). Conclusions: The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.Department of Prosthesis and Periodontology Division of Periodontics Piracicaba Dental School State University of CampinasDepartment of Diagnosis and Surgery Division of Periodontics State University of São Paulo CampusUniversidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Sangiorgio, João Paulo MenckDa Silva Neves, Felipe LucasDos Santos, Manuela RochaFrança-Grohmann, Isabela LimaCasarin, Renato Corrêa VianaCasati, Márcio ZaffalonSantamaria, Mauro PedrineSallum, Enilson Antonio2022-04-28T19:07:09Z2022-04-28T19:07:09Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1309-1318http://dx.doi.org/10.1902/jop.2017.170126Journal of Periodontology, v. 88, n. 12, p. 1309-1318, 2017.0022-3492http://hdl.handle.net/11449/22097410.1902/jop.2017.1701262-s2.0-85035353467Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Periodontologyinfo:eu-repo/semantics/openAccess2022-04-28T19:07:09Zoai:repositorio.unesp.br:11449/220974Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:39:50.490675Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
title Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
spellingShingle Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
Sangiorgio, João Paulo Menck
Collagen
Enamel matrix proteins
General surgery
Gingival recession
Surgery, plastic
Tooth root
title_short Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
title_full Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
title_fullStr Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
title_full_unstemmed Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
title_sort Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes
author Sangiorgio, João Paulo Menck
author_facet Sangiorgio, João Paulo Menck
Da Silva Neves, Felipe Lucas
Dos Santos, Manuela Rocha
França-Grohmann, Isabela Lima
Casarin, Renato Corrêa Viana
Casati, Márcio Zaffalon
Santamaria, Mauro Pedrine
Sallum, Enilson Antonio
author_role author
author2 Da Silva Neves, Felipe Lucas
Dos Santos, Manuela Rocha
França-Grohmann, Isabela Lima
Casarin, Renato Corrêa Viana
Casati, Márcio Zaffalon
Santamaria, Mauro Pedrine
Sallum, Enilson Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Sangiorgio, João Paulo Menck
Da Silva Neves, Felipe Lucas
Dos Santos, Manuela Rocha
França-Grohmann, Isabela Lima
Casarin, Renato Corrêa Viana
Casati, Márcio Zaffalon
Santamaria, Mauro Pedrine
Sallum, Enilson Antonio
dc.subject.por.fl_str_mv Collagen
Enamel matrix proteins
General surgery
Gingival recession
Surgery, plastic
Tooth root
topic Collagen
Enamel matrix proteins
General surgery
Gingival recession
Surgery, plastic
Tooth root
description Background: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and/or EMD. Methods: Sixty-eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery. Results: The obtained root coverage was 68.04% ± 24.11% for CAF; 87.20% ± 15.01% for CAF + CM; 88.77% ± 20.66% for CAF + EMD; and 91.59% ± 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (P <0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (P <0.05). Keratinized tissue thickness gain was significant only in CM-treated groups (P <0.05). Conclusions: The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
2022-04-28T19:07:09Z
2022-04-28T19:07:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1902/jop.2017.170126
Journal of Periodontology, v. 88, n. 12, p. 1309-1318, 2017.
0022-3492
http://hdl.handle.net/11449/220974
10.1902/jop.2017.170126
2-s2.0-85035353467
url http://dx.doi.org/10.1902/jop.2017.170126
http://hdl.handle.net/11449/220974
identifier_str_mv Journal of Periodontology, v. 88, n. 12, p. 1309-1318, 2017.
0022-3492
10.1902/jop.2017.170126
2-s2.0-85035353467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Periodontology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1309-1318
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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