Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.niox.2011.12.008 http://hdl.handle.net/11449/14999 |
Resumo: | Drugs that release nitric oxide (NO) usually have limitations due to their harmful effects. Sodium nitroprusside (SNP) induces a rapid hypotension that leads to reflex tachycardia, which could be an undesirable effect in patients with heart disease, a common feature of hypertension. The nitrosyl ruthenium complex [Ru(terpy)(bdq)NO+](3+) (TERPY) is a NO donor that is less potent than SNP in denuded aortic rings. This study evaluated the hypotension and vasorelaxation induced by this NO donor in Wistar (W) and spontaneously hypertensive rats (SHR) and compared to the results obtained with SNP. Differently from the hypotension induced by SNP, the action of TERPY was slow, long lasting and it did not lead to reflex tachycardia in both groups. The hypotension induced by the NO-donors was more potent in SHR than in W. TERPY induced relaxation with similar efficacy to SNP, although its potency is lower in both strains. The relaxation induced by TERPY is similar in W and SHR, but SNP is more potent and efficient in SHR. The relaxation induced by TERPY is partially dependent on guanylate cyclase in SHR aorta. The NO released from the NO donors measured with DAF-2 da by confocal microscopy shows that TERPY releases similar amounts of NO in W and SHR, while SNP releases more NO in SHR aortic rings. (c) 2012 Elsevier B.V. All rights reserved. |
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Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive ratsNitric oxideNO-donorHypotensionVasodilationSHRDrugs that release nitric oxide (NO) usually have limitations due to their harmful effects. Sodium nitroprusside (SNP) induces a rapid hypotension that leads to reflex tachycardia, which could be an undesirable effect in patients with heart disease, a common feature of hypertension. The nitrosyl ruthenium complex [Ru(terpy)(bdq)NO+](3+) (TERPY) is a NO donor that is less potent than SNP in denuded aortic rings. This study evaluated the hypotension and vasorelaxation induced by this NO donor in Wistar (W) and spontaneously hypertensive rats (SHR) and compared to the results obtained with SNP. Differently from the hypotension induced by SNP, the action of TERPY was slow, long lasting and it did not lead to reflex tachycardia in both groups. The hypotension induced by the NO-donors was more potent in SHR than in W. TERPY induced relaxation with similar efficacy to SNP, although its potency is lower in both strains. The relaxation induced by TERPY is similar in W and SHR, but SNP is more potent and efficient in SHR. The relaxation induced by TERPY is partially dependent on guanylate cyclase in SHR aorta. The NO released from the NO donors measured with DAF-2 da by confocal microscopy shows that TERPY releases similar amounts of NO in W and SHR, while SNP releases more NO in SHR aortic rings. (c) 2012 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)State Univ São Paulo, UNESP, Fac Dent Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, BrazilUniv São Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP, BrazilState Univ São Paulo, UNESP, Fac Dent Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, BrazilAcademic Press Inc. Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Munhoz, Felipe C. [UNESP]Potje, Simone R. [UNESP]Pereira, Amanda C.Daruge, Marcella G.da Silva, Roberto S.Bendhack, Lusiane M.Silva, Cristina Antoniali [UNESP]2013-09-30T18:29:19Z2014-05-20T13:43:06Z2013-09-30T18:29:19Z2014-05-20T13:43:06Z2012-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article111-117application/pdfhttp://dx.doi.org/10.1016/j.niox.2011.12.008Nitric Oxide-biology and Chemistry. San Diego: Academic Press Inc. Elsevier B.V., v. 26, n. 2, p. 111-117, 2012.1089-8603http://hdl.handle.net/11449/1499910.1016/j.niox.2011.12.008WOS:000301700000005WOS000301700000005.pdf6656433539493879Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNitric Oxide: Biology and Chemistry4.3671,278info:eu-repo/semantics/openAccess2023-12-19T06:25:31Zoai:repositorio.unesp.br:11449/14999Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:46:12.481295Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
title |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
spellingShingle |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats Munhoz, Felipe C. [UNESP] Nitric oxide NO-donor Hypotension Vasodilation SHR |
title_short |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
title_full |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
title_fullStr |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
title_full_unstemmed |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
title_sort |
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats |
author |
Munhoz, Felipe C. [UNESP] |
author_facet |
Munhoz, Felipe C. [UNESP] Potje, Simone R. [UNESP] Pereira, Amanda C. Daruge, Marcella G. da Silva, Roberto S. Bendhack, Lusiane M. Silva, Cristina Antoniali [UNESP] |
author_role |
author |
author2 |
Potje, Simone R. [UNESP] Pereira, Amanda C. Daruge, Marcella G. da Silva, Roberto S. Bendhack, Lusiane M. Silva, Cristina Antoniali [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Munhoz, Felipe C. [UNESP] Potje, Simone R. [UNESP] Pereira, Amanda C. Daruge, Marcella G. da Silva, Roberto S. Bendhack, Lusiane M. Silva, Cristina Antoniali [UNESP] |
dc.subject.por.fl_str_mv |
Nitric oxide NO-donor Hypotension Vasodilation SHR |
topic |
Nitric oxide NO-donor Hypotension Vasodilation SHR |
description |
Drugs that release nitric oxide (NO) usually have limitations due to their harmful effects. Sodium nitroprusside (SNP) induces a rapid hypotension that leads to reflex tachycardia, which could be an undesirable effect in patients with heart disease, a common feature of hypertension. The nitrosyl ruthenium complex [Ru(terpy)(bdq)NO+](3+) (TERPY) is a NO donor that is less potent than SNP in denuded aortic rings. This study evaluated the hypotension and vasorelaxation induced by this NO donor in Wistar (W) and spontaneously hypertensive rats (SHR) and compared to the results obtained with SNP. Differently from the hypotension induced by SNP, the action of TERPY was slow, long lasting and it did not lead to reflex tachycardia in both groups. The hypotension induced by the NO-donors was more potent in SHR than in W. TERPY induced relaxation with similar efficacy to SNP, although its potency is lower in both strains. The relaxation induced by TERPY is similar in W and SHR, but SNP is more potent and efficient in SHR. The relaxation induced by TERPY is partially dependent on guanylate cyclase in SHR aorta. The NO released from the NO donors measured with DAF-2 da by confocal microscopy shows that TERPY releases similar amounts of NO in W and SHR, while SNP releases more NO in SHR aortic rings. (c) 2012 Elsevier B.V. All rights reserved. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-15 2013-09-30T18:29:19Z 2013-09-30T18:29:19Z 2014-05-20T13:43:06Z 2014-05-20T13:43:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.niox.2011.12.008 Nitric Oxide-biology and Chemistry. San Diego: Academic Press Inc. Elsevier B.V., v. 26, n. 2, p. 111-117, 2012. 1089-8603 http://hdl.handle.net/11449/14999 10.1016/j.niox.2011.12.008 WOS:000301700000005 WOS000301700000005.pdf 6656433539493879 |
url |
http://dx.doi.org/10.1016/j.niox.2011.12.008 http://hdl.handle.net/11449/14999 |
identifier_str_mv |
Nitric Oxide-biology and Chemistry. San Diego: Academic Press Inc. Elsevier B.V., v. 26, n. 2, p. 111-117, 2012. 1089-8603 10.1016/j.niox.2011.12.008 WOS:000301700000005 WOS000301700000005.pdf 6656433539493879 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nitric Oxide: Biology and Chemistry 4.367 1,278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
111-117 application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc. Elsevier B.V. |
publisher.none.fl_str_mv |
Academic Press Inc. Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129246126669824 |