Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center

Detalhes bibliográficos
Autor(a) principal: Tomo, Saygo [UNESP]
Data de Publicação: 2020
Outros Autores: Neto, Sebastiao Conrado [UNESP], Collado, Francisco Urbano [UNESP], Mazza Sundefeld, Maria Lucia Marcal [UNESP], Bernabe, Daniel Calera [UNESP], Biasoli, Eder Ricardo [UNESP], Miyahara, Glauco Issamu [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4317/medoral.23461
http://hdl.handle.net/11449/196994
Resumo: Background: To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. Material and Methods: Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the inclusion criteria of the study. Two additional groups of middle-aged (n=89) and old (n=89) adults were set to comparative analysis. Results: Young patients represented 11.9% of all patients diagnosed with HNSCC. Women were more affected by HNSCC in the young and elder groups (p=0.04), and young patients were more prone to be non-smokers (p=0.01) and have lymph node metastasis at the time of diagnosis (p=0.04). In the young group, patients diagnosed with the disease in advanced stages were more prone to have a positive familial history of cancer (p=0.04), a positive status of alcohol consumption (p=0.03), and to be heavy drinkers (p=0.01). Survival was not different for the young group in comparison to the other groups. Conclusions: HNSCC in young patients had a different profile when compared to older patients, especially regarding sex and exposure to the classic risk factors for this disease. The survival of the young group is similar to the older groups and advanced clinical stage is predictor of worse survival.
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spelling Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized centerMouth neoplasmsyoung adultepidemiologyBackground: To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. Material and Methods: Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the inclusion criteria of the study. Two additional groups of middle-aged (n=89) and old (n=89) adults were set to comparative analysis. Results: Young patients represented 11.9% of all patients diagnosed with HNSCC. Women were more affected by HNSCC in the young and elder groups (p=0.04), and young patients were more prone to be non-smokers (p=0.01) and have lymph node metastasis at the time of diagnosis (p=0.04). In the young group, patients diagnosed with the disease in advanced stages were more prone to have a positive familial history of cancer (p=0.04), a positive status of alcohol consumption (p=0.03), and to be heavy drinkers (p=0.01). Survival was not different for the young group in comparison to the other groups. Conclusions: HNSCC in young patients had a different profile when compared to older patients, especially regarding sex and exposure to the classic risk factors for this disease. The survival of the young group is similar to the older groups and advanced clinical stage is predictor of worse survival.Sao Paulo State Univ UNESP, Oral Oncol Ctr, Aracatuba Dent Sch, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, BrazilSao Paulo State Univ UNESP, Oral Oncol Ctr, Aracatuba Dent Sch, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, BrazilMedicina Oral S LUniversidade Estadual Paulista (Unesp)Tomo, Saygo [UNESP]Neto, Sebastiao Conrado [UNESP]Collado, Francisco Urbano [UNESP]Mazza Sundefeld, Maria Lucia Marcal [UNESP]Bernabe, Daniel Calera [UNESP]Biasoli, Eder Ricardo [UNESP]Miyahara, Glauco Issamu [UNESP]2020-12-10T20:02:53Z2020-12-10T20:02:53Z2020-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleE416-E424http://dx.doi.org/10.4317/medoral.23461Medicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 25, n. 3, p. E416-E424, 2020.1698-6946http://hdl.handle.net/11449/19699410.4317/medoral.23461WOS:000541545100016Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedicina Oral Patologia Oral Y Cirugia Bucalinfo:eu-repo/semantics/openAccess2024-04-11T20:16:33Zoai:repositorio.unesp.br:11449/196994Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:55.509530Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
title Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
spellingShingle Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
Tomo, Saygo [UNESP]
Mouth neoplasms
young adult
epidemiology
title_short Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
title_full Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
title_fullStr Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
title_full_unstemmed Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
title_sort Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center
author Tomo, Saygo [UNESP]
author_facet Tomo, Saygo [UNESP]
Neto, Sebastiao Conrado [UNESP]
Collado, Francisco Urbano [UNESP]
Mazza Sundefeld, Maria Lucia Marcal [UNESP]
Bernabe, Daniel Calera [UNESP]
Biasoli, Eder Ricardo [UNESP]
Miyahara, Glauco Issamu [UNESP]
author_role author
author2 Neto, Sebastiao Conrado [UNESP]
Collado, Francisco Urbano [UNESP]
Mazza Sundefeld, Maria Lucia Marcal [UNESP]
Bernabe, Daniel Calera [UNESP]
Biasoli, Eder Ricardo [UNESP]
Miyahara, Glauco Issamu [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Tomo, Saygo [UNESP]
Neto, Sebastiao Conrado [UNESP]
Collado, Francisco Urbano [UNESP]
Mazza Sundefeld, Maria Lucia Marcal [UNESP]
Bernabe, Daniel Calera [UNESP]
Biasoli, Eder Ricardo [UNESP]
Miyahara, Glauco Issamu [UNESP]
dc.subject.por.fl_str_mv Mouth neoplasms
young adult
epidemiology
topic Mouth neoplasms
young adult
epidemiology
description Background: To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. Material and Methods: Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the inclusion criteria of the study. Two additional groups of middle-aged (n=89) and old (n=89) adults were set to comparative analysis. Results: Young patients represented 11.9% of all patients diagnosed with HNSCC. Women were more affected by HNSCC in the young and elder groups (p=0.04), and young patients were more prone to be non-smokers (p=0.01) and have lymph node metastasis at the time of diagnosis (p=0.04). In the young group, patients diagnosed with the disease in advanced stages were more prone to have a positive familial history of cancer (p=0.04), a positive status of alcohol consumption (p=0.03), and to be heavy drinkers (p=0.01). Survival was not different for the young group in comparison to the other groups. Conclusions: HNSCC in young patients had a different profile when compared to older patients, especially regarding sex and exposure to the classic risk factors for this disease. The survival of the young group is similar to the older groups and advanced clinical stage is predictor of worse survival.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-10T20:02:53Z
2020-12-10T20:02:53Z
2020-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4317/medoral.23461
Medicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 25, n. 3, p. E416-E424, 2020.
1698-6946
http://hdl.handle.net/11449/196994
10.4317/medoral.23461
WOS:000541545100016
url http://dx.doi.org/10.4317/medoral.23461
http://hdl.handle.net/11449/196994
identifier_str_mv Medicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 25, n. 3, p. E416-E424, 2020.
1698-6946
10.4317/medoral.23461
WOS:000541545100016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medicina Oral Patologia Oral Y Cirugia Bucal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv E416-E424
dc.publisher.none.fl_str_mv Medicina Oral S L
publisher.none.fl_str_mv Medicina Oral S L
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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