Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/10253890.2018.1437413 http://hdl.handle.net/11449/170650 |
Resumo: | Obesity and chronic stress are considered independent risk factors for the development of cardiovascular diseases and changes in autonomic system activity. However, the cardiovascular consequences induced by the association between high-fat diet (HFD) and chronic stress are not fully understood. We hypothesized that the association between HFD and exposure to a chronic variable stress (CVS) protocol for four weeks might exacerbate the cardiovascular and metabolic disturbances in rats when compared to these factors singly. To test this hypothesis, male Wistar rats were divided into four groups: control-standard chow diet (SD; n = 8); control-HFD (n = 8); CVS-SD (n = 8); and CVS-HFD (n = 8). The CVS consisted of repeated exposure of the rats to different inescapable and unpredictable stressors (restraint tress; damp sawdust, cold, swim stress and light cycle inversion). We evaluated cardiovascular function, autonomic activity, dietary intake, adiposity and metabolism. The HFD increased body weight, adiposity and blood glucose concentration (∼15%) in both control and CVS rats. The CVS–HFD rats showed decreased insulin sensitivity (25%) compared to CVS–SD rats. The control-HFD and CVS–HFD rats presented increased intrinsic heart rate (HR) values (∼8%). CVS increased cardiac sympathetic activity (∼65%) in both SD- and HFD-fed rats. The HFD increased basal HR (∼10%). Blood pressure and baroreflex analyzes showed no differences among the experimental groups. In conclusion, the present data indicate absence of interaction on autonomic imbalance evoked by either CVS or HFD. Additionally, HFD increased HR and evoked metabolic disruptions which are independent of stress exposure. |
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Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in ratsAdipose storesautonomic activitybaroreflex activitychronic variable stressinsulin resistanceintrinsic heart rateObesity and chronic stress are considered independent risk factors for the development of cardiovascular diseases and changes in autonomic system activity. However, the cardiovascular consequences induced by the association between high-fat diet (HFD) and chronic stress are not fully understood. We hypothesized that the association between HFD and exposure to a chronic variable stress (CVS) protocol for four weeks might exacerbate the cardiovascular and metabolic disturbances in rats when compared to these factors singly. To test this hypothesis, male Wistar rats were divided into four groups: control-standard chow diet (SD; n = 8); control-HFD (n = 8); CVS-SD (n = 8); and CVS-HFD (n = 8). The CVS consisted of repeated exposure of the rats to different inescapable and unpredictable stressors (restraint tress; damp sawdust, cold, swim stress and light cycle inversion). We evaluated cardiovascular function, autonomic activity, dietary intake, adiposity and metabolism. The HFD increased body weight, adiposity and blood glucose concentration (∼15%) in both control and CVS rats. The CVS–HFD rats showed decreased insulin sensitivity (25%) compared to CVS–SD rats. The control-HFD and CVS–HFD rats presented increased intrinsic heart rate (HR) values (∼8%). CVS increased cardiac sympathetic activity (∼65%) in both SD- and HFD-fed rats. The HFD increased basal HR (∼10%). Blood pressure and baroreflex analyzes showed no differences among the experimental groups. In conclusion, the present data indicate absence of interaction on autonomic imbalance evoked by either CVS or HFD. Additionally, HFD increased HR and evoked metabolic disruptions which are independent of stress exposure.Department of Physiological Sciences Biological Sciences Centre Federal University of Santa Catarina (UFSC)Laboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesUniversidade Federal de Santa Catarina (UFSC)Universidade Estadual Paulista (Unesp)Simas, Bruna B.Nunes, Everson A.Crestani, Carlos C. [UNESP]Speretta, Guilherme F.2018-12-11T16:51:51Z2018-12-11T16:51:51Z2018-05-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article247-256http://dx.doi.org/10.1080/10253890.2018.1437413Stress, v. 21, n. 3, p. 247-256, 2018.1607-88881025-3890http://hdl.handle.net/11449/17065010.1080/10253890.2018.14374132-s2.0-85041799265Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengStress1,2601,260info:eu-repo/semantics/openAccess2021-10-23T15:33:41Zoai:repositorio.unesp.br:11449/170650Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:43:09.438655Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
title |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
spellingShingle |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats Simas, Bruna B. Adipose stores autonomic activity baroreflex activity chronic variable stress insulin resistance intrinsic heart rate |
title_short |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
title_full |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
title_fullStr |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
title_full_unstemmed |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
title_sort |
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats |
author |
Simas, Bruna B. |
author_facet |
Simas, Bruna B. Nunes, Everson A. Crestani, Carlos C. [UNESP] Speretta, Guilherme F. |
author_role |
author |
author2 |
Nunes, Everson A. Crestani, Carlos C. [UNESP] Speretta, Guilherme F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Santa Catarina (UFSC) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Simas, Bruna B. Nunes, Everson A. Crestani, Carlos C. [UNESP] Speretta, Guilherme F. |
dc.subject.por.fl_str_mv |
Adipose stores autonomic activity baroreflex activity chronic variable stress insulin resistance intrinsic heart rate |
topic |
Adipose stores autonomic activity baroreflex activity chronic variable stress insulin resistance intrinsic heart rate |
description |
Obesity and chronic stress are considered independent risk factors for the development of cardiovascular diseases and changes in autonomic system activity. However, the cardiovascular consequences induced by the association between high-fat diet (HFD) and chronic stress are not fully understood. We hypothesized that the association between HFD and exposure to a chronic variable stress (CVS) protocol for four weeks might exacerbate the cardiovascular and metabolic disturbances in rats when compared to these factors singly. To test this hypothesis, male Wistar rats were divided into four groups: control-standard chow diet (SD; n = 8); control-HFD (n = 8); CVS-SD (n = 8); and CVS-HFD (n = 8). The CVS consisted of repeated exposure of the rats to different inescapable and unpredictable stressors (restraint tress; damp sawdust, cold, swim stress and light cycle inversion). We evaluated cardiovascular function, autonomic activity, dietary intake, adiposity and metabolism. The HFD increased body weight, adiposity and blood glucose concentration (∼15%) in both control and CVS rats. The CVS–HFD rats showed decreased insulin sensitivity (25%) compared to CVS–SD rats. The control-HFD and CVS–HFD rats presented increased intrinsic heart rate (HR) values (∼8%). CVS increased cardiac sympathetic activity (∼65%) in both SD- and HFD-fed rats. The HFD increased basal HR (∼10%). Blood pressure and baroreflex analyzes showed no differences among the experimental groups. In conclusion, the present data indicate absence of interaction on autonomic imbalance evoked by either CVS or HFD. Additionally, HFD increased HR and evoked metabolic disruptions which are independent of stress exposure. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:51:51Z 2018-12-11T16:51:51Z 2018-05-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/10253890.2018.1437413 Stress, v. 21, n. 3, p. 247-256, 2018. 1607-8888 1025-3890 http://hdl.handle.net/11449/170650 10.1080/10253890.2018.1437413 2-s2.0-85041799265 |
url |
http://dx.doi.org/10.1080/10253890.2018.1437413 http://hdl.handle.net/11449/170650 |
identifier_str_mv |
Stress, v. 21, n. 3, p. 247-256, 2018. 1607-8888 1025-3890 10.1080/10253890.2018.1437413 2-s2.0-85041799265 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Stress 1,260 1,260 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
247-256 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129350115000320 |