Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1152/ajpregu.00295.2000 http://hdl.handle.net/11449/224233 |
Resumo: | Adult rats deprived of water for 24-30 h were allowed to rehydrate by ingesting only water for 1-2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 ± 0.8 ml/2 h; n = 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na+; 2) decreased blood volume; and 3) reduced total body Na+; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na+ concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water. |
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Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genesCircumventricular organsDehydrationHypovolemiaSalt intakeThirstAdult rats deprived of water for 24-30 h were allowed to rehydrate by ingesting only water for 1-2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 ± 0.8 ml/2 h; n = 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na+; 2) decreased blood volume; and 3) reduced total body Na+; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na+ concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.Departments of Psychology Pharmacology and Exercise Science Cardiovascular Center University of Iowa, Iowa City, IA 52242-1407Department of Physiology and Pathology School of Dentistry Paulista State University, Sao Paulo 14801-903Dept. of Physiology and Pathology-School of Dentistry Paulista State Univ. (UNESP), Sao Paulo 14801-903Department of Physiology and Pathology School of Dentistry Paulista State University, Sao Paulo 14801-903Dept. of Physiology and Pathology-School of Dentistry Paulista State Univ. (UNESP), Sao Paulo 14801-903University of IowaUniversidade Estadual Paulista (UNESP)De Luca Jr., Laurival A. [UNESP]Xu, Zhice [UNESP]Schoorlemmer, Guus H. M. [UNESP]Thunhorst, Robert L. [UNESP]Beltz, Terry G. [UNESP]Menani, José V. [UNESP]Johnson, Alan Kim [UNESP]2022-04-28T19:55:26Z2022-04-28T19:55:26Z2002-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1152/ajpregu.00295.2000American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 282, n. 2 51-2, 2002.0363-6119http://hdl.handle.net/11449/22423310.1152/ajpregu.00295.20002-s2.0-0036081479Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiologyinfo:eu-repo/semantics/openAccess2022-04-28T19:55:26Zoai:repositorio.unesp.br:11449/224233Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:51:02.349911Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
title |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
spellingShingle |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes De Luca Jr., Laurival A. [UNESP] Circumventricular organs Dehydration Hypovolemia Salt intake Thirst |
title_short |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
title_full |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
title_fullStr |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
title_full_unstemmed |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
title_sort |
Water deprivation-induced sodium appetite: Humoral and cardiovascular mediators and immediate early genes |
author |
De Luca Jr., Laurival A. [UNESP] |
author_facet |
De Luca Jr., Laurival A. [UNESP] Xu, Zhice [UNESP] Schoorlemmer, Guus H. M. [UNESP] Thunhorst, Robert L. [UNESP] Beltz, Terry G. [UNESP] Menani, José V. [UNESP] Johnson, Alan Kim [UNESP] |
author_role |
author |
author2 |
Xu, Zhice [UNESP] Schoorlemmer, Guus H. M. [UNESP] Thunhorst, Robert L. [UNESP] Beltz, Terry G. [UNESP] Menani, José V. [UNESP] Johnson, Alan Kim [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
University of Iowa Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
De Luca Jr., Laurival A. [UNESP] Xu, Zhice [UNESP] Schoorlemmer, Guus H. M. [UNESP] Thunhorst, Robert L. [UNESP] Beltz, Terry G. [UNESP] Menani, José V. [UNESP] Johnson, Alan Kim [UNESP] |
dc.subject.por.fl_str_mv |
Circumventricular organs Dehydration Hypovolemia Salt intake Thirst |
topic |
Circumventricular organs Dehydration Hypovolemia Salt intake Thirst |
description |
Adult rats deprived of water for 24-30 h were allowed to rehydrate by ingesting only water for 1-2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 ± 0.8 ml/2 h; n = 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na+; 2) decreased blood volume; and 3) reduced total body Na+; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na+ concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-01-01 2022-04-28T19:55:26Z 2022-04-28T19:55:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1152/ajpregu.00295.2000 American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 282, n. 2 51-2, 2002. 0363-6119 http://hdl.handle.net/11449/224233 10.1152/ajpregu.00295.2000 2-s2.0-0036081479 |
url |
http://dx.doi.org/10.1152/ajpregu.00295.2000 http://hdl.handle.net/11449/224233 |
identifier_str_mv |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 282, n. 2 51-2, 2002. 0363-6119 10.1152/ajpregu.00295.2000 2-s2.0-0036081479 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129128401993728 |