Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-695X2011005000193 http://hdl.handle.net/11449/290 |
Resumo: | Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated with an increased Helicobacter pyloririsk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and oxidative burst antioxidantactivitiesofa1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. Paepalanthus latipes The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol- and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections. |
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Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes5-methoxy-3,4-dehydroxanthomegninHelicobacter pylorioxidative burstPaepalanthus latipesHelicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated with an increased Helicobacter pyloririsk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and oxidative burst antioxidantactivitiesofa1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. Paepalanthus latipes The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol- and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Espírito Santo (UFES) Departamento de Ciências FarmacêuticasUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas de AraraquaraUniversidade Estadual Paulista Instituto de Química de AraraquaraUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas de AraraquaraUniversidade Estadual Paulista Instituto de Química de AraraquaraSociedade Brasileira de FarmacognosiaUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Kitagawa, Rodrigo RezendeBonacorsi, Cibele [UNESP]Fonseca, Luiz Marcos da [UNESP]Vilegas, Wagner [UNESP]Raddi, Maria Stella Gonçalves [UNESP]2014-05-20T13:12:18Z2014-05-20T13:12:18Z2012-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article53-59application/pdfhttp://dx.doi.org/10.1590/S0102-695X2011005000193Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 1, p. 53-59, 2012.0102-695Xhttp://hdl.handle.net/11449/29010.1590/S0102-695X2011005000193S0102-695X2012000100008S0102-695X2012000100008.pdf79278772243268370000-0003-3032-2556SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Farmacognosia1.596info:eu-repo/semantics/openAccess2024-06-21T15:19:30Zoai:repositorio.unesp.br:11449/290Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:13:26.116593Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
title |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
spellingShingle |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes Kitagawa, Rodrigo Rezende 5-methoxy-3,4-dehydroxanthomegnin Helicobacter pylori oxidative burst Paepalanthus latipes |
title_short |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
title_full |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
title_fullStr |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
title_full_unstemmed |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
title_sort |
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes |
author |
Kitagawa, Rodrigo Rezende |
author_facet |
Kitagawa, Rodrigo Rezende Bonacorsi, Cibele [UNESP] Fonseca, Luiz Marcos da [UNESP] Vilegas, Wagner [UNESP] Raddi, Maria Stella Gonçalves [UNESP] |
author_role |
author |
author2 |
Bonacorsi, Cibele [UNESP] Fonseca, Luiz Marcos da [UNESP] Vilegas, Wagner [UNESP] Raddi, Maria Stella Gonçalves [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Espírito Santo (UFES) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Kitagawa, Rodrigo Rezende Bonacorsi, Cibele [UNESP] Fonseca, Luiz Marcos da [UNESP] Vilegas, Wagner [UNESP] Raddi, Maria Stella Gonçalves [UNESP] |
dc.subject.por.fl_str_mv |
5-methoxy-3,4-dehydroxanthomegnin Helicobacter pylori oxidative burst Paepalanthus latipes |
topic |
5-methoxy-3,4-dehydroxanthomegnin Helicobacter pylori oxidative burst Paepalanthus latipes |
description |
Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated with an increased Helicobacter pyloririsk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and oxidative burst antioxidantactivitiesofa1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. Paepalanthus latipes The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol- and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 2014-05-20T13:12:18Z 2014-05-20T13:12:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-695X2011005000193 Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 1, p. 53-59, 2012. 0102-695X http://hdl.handle.net/11449/290 10.1590/S0102-695X2011005000193 S0102-695X2012000100008 S0102-695X2012000100008.pdf 7927877224326837 0000-0003-3032-2556 |
url |
http://dx.doi.org/10.1590/S0102-695X2011005000193 http://hdl.handle.net/11449/290 |
identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 1, p. 53-59, 2012. 0102-695X 10.1590/S0102-695X2011005000193 S0102-695X2012000100008 S0102-695X2012000100008.pdf 7927877224326837 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Farmacognosia 1.596 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
53-59 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129405936992256 |