Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4238/vol9-3gmr803 http://hdl.handle.net/11449/72107 |
Resumo: | We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four blood banks in the same areas. DNA was extracted using the Easy-DNA(TM) extraction kit. ABO genotyping was performed using PCR/RFLP. There was a high frequency of ABO*O01O01. ABO*AO01 was the second most frequent genotype, and the third most frequent genotype was ABO*BO01. There were low frequencies of the ABO*O01O02, ABO*AA, ABO*AB, ABO*BB, and ABO*O02O02 genotypes. We analyzed the alleles of the O phenotype; the O(1variant) allele was the most frequent, both in malaria and non-malaria groups; consequently, the homozygous genotype O(1)(v)O(1)(v) was the most frequently observed. There was no evidence of the homozygous O(2) allele. Significant differences were not detected in the frequency of individuals with the various alleles in the comparison of the malaria patients and the general population (blood donors). |
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Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region.adolescentadultagedblood donorblood group ABO systemBrazilfemalegenetic polymorphismgeneticshumanmalaria falciparummalemiddle agedpolymerase chain reactionrestriction fragment length polymorphismABO Blood-Group SystemAdolescentAdultAgedBlood DonorsFemaleHumansMalaria, FalciparumMaleMiddle AgedPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthYoung AdultWe investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four blood banks in the same areas. DNA was extracted using the Easy-DNA(TM) extraction kit. ABO genotyping was performed using PCR/RFLP. There was a high frequency of ABO*O01O01. ABO*AO01 was the second most frequent genotype, and the third most frequent genotype was ABO*BO01. There were low frequencies of the ABO*O01O02, ABO*AA, ABO*AB, ABO*BB, and ABO*O02O02 genotypes. We analyzed the alleles of the O phenotype; the O(1variant) allele was the most frequent, both in malaria and non-malaria groups; consequently, the homozygous genotype O(1)(v)O(1)(v) was the most frequently observed. There was no evidence of the homozygous O(2) allele. Significant differences were not detected in the frequency of individuals with the various alleles in the comparison of the malaria patients and the general population (blood donors).Universidade Estadual Paulista (Unesp)Carvalho, D. B.de Mattos, L. C.Souza-Neiras, W. C.Bonini-Domingos, C. R.Cósimo, A. B.Storti-Melo, L. M.Cassiano, G. C.Couto, A. A.Cordeiro, A. J.Rossit, A. R.Machado, R. L.2014-05-27T11:25:22Z2014-05-27T11:25:22Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1443-1449application/pdfhttp://dx.doi.org/10.4238/vol9-3gmr803Genetics and molecular research : GMR, v. 9, n. 3, p. 1443-1449, 2010.1676-5680http://hdl.handle.net/11449/7210710.4238/vol9-3gmr8032-s2.0-848554523042-s2.0-84855452304.pdf32794280661767190000-0002-4603-9467Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and molecular research : GMR0,439info:eu-repo/semantics/openAccess2023-11-17T06:10:59Zoai:repositorio.unesp.br:11449/72107Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:55:59.264942Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
title |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
spellingShingle |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. Carvalho, D. B. adolescent adult aged blood donor blood group ABO system Brazil female genetic polymorphism genetics human malaria falciparum male middle aged polymerase chain reaction restriction fragment length polymorphism ABO Blood-Group System Adolescent Adult Aged Blood Donors Female Humans Malaria, Falciparum Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Young Adult |
title_short |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
title_full |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
title_fullStr |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
title_full_unstemmed |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
title_sort |
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region. |
author |
Carvalho, D. B. |
author_facet |
Carvalho, D. B. de Mattos, L. C. Souza-Neiras, W. C. Bonini-Domingos, C. R. Cósimo, A. B. Storti-Melo, L. M. Cassiano, G. C. Couto, A. A. Cordeiro, A. J. Rossit, A. R. Machado, R. L. |
author_role |
author |
author2 |
de Mattos, L. C. Souza-Neiras, W. C. Bonini-Domingos, C. R. Cósimo, A. B. Storti-Melo, L. M. Cassiano, G. C. Couto, A. A. Cordeiro, A. J. Rossit, A. R. Machado, R. L. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Carvalho, D. B. de Mattos, L. C. Souza-Neiras, W. C. Bonini-Domingos, C. R. Cósimo, A. B. Storti-Melo, L. M. Cassiano, G. C. Couto, A. A. Cordeiro, A. J. Rossit, A. R. Machado, R. L. |
dc.subject.por.fl_str_mv |
adolescent adult aged blood donor blood group ABO system Brazil female genetic polymorphism genetics human malaria falciparum male middle aged polymerase chain reaction restriction fragment length polymorphism ABO Blood-Group System Adolescent Adult Aged Blood Donors Female Humans Malaria, Falciparum Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Young Adult |
topic |
adolescent adult aged blood donor blood group ABO system Brazil female genetic polymorphism genetics human malaria falciparum male middle aged polymerase chain reaction restriction fragment length polymorphism ABO Blood-Group System Adolescent Adult Aged Blood Donors Female Humans Malaria, Falciparum Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Young Adult |
description |
We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four blood banks in the same areas. DNA was extracted using the Easy-DNA(TM) extraction kit. ABO genotyping was performed using PCR/RFLP. There was a high frequency of ABO*O01O01. ABO*AO01 was the second most frequent genotype, and the third most frequent genotype was ABO*BO01. There were low frequencies of the ABO*O01O02, ABO*AA, ABO*AB, ABO*BB, and ABO*O02O02 genotypes. We analyzed the alleles of the O phenotype; the O(1variant) allele was the most frequent, both in malaria and non-malaria groups; consequently, the homozygous genotype O(1)(v)O(1)(v) was the most frequently observed. There was no evidence of the homozygous O(2) allele. Significant differences were not detected in the frequency of individuals with the various alleles in the comparison of the malaria patients and the general population (blood donors). |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2014-05-27T11:25:22Z 2014-05-27T11:25:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4238/vol9-3gmr803 Genetics and molecular research : GMR, v. 9, n. 3, p. 1443-1449, 2010. 1676-5680 http://hdl.handle.net/11449/72107 10.4238/vol9-3gmr803 2-s2.0-84855452304 2-s2.0-84855452304.pdf 3279428066176719 0000-0002-4603-9467 |
url |
http://dx.doi.org/10.4238/vol9-3gmr803 http://hdl.handle.net/11449/72107 |
identifier_str_mv |
Genetics and molecular research : GMR, v. 9, n. 3, p. 1443-1449, 2010. 1676-5680 10.4238/vol9-3gmr803 2-s2.0-84855452304 2-s2.0-84855452304.pdf 3279428066176719 0000-0002-4603-9467 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and molecular research : GMR 0,439 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1443-1449 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128876696567808 |