Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000363350 http://hdl.handle.net/11449/158416 |
Resumo: | Objective: The present study analyzed the effects of lipopolysaccharide (LPS) on maternal behavior during lactation and possible correlations with changes in emotional and immune responses in offspring. Methods: Lactating rats received 100 mu g/kg LPS, and the control group received saline solution on lactation day (LD) 3. Maternal general activity and maternal behavior were observed on LD5 (i.e. the day that the peak of fever occurred). In male pups, hematological parameters and ultrasonic vocalizations (USVs) were assessed on LD5. At weaning, an additional dose of LPS (50 mu g/kg, i.p.) was administered in male pups, and open-field behavior, oxidative burst and phagocytosis were evaluated. Results: A reduction in the time in which dams retrieved the pups was observed, whereas no effects on maternal aggressive behavior were found. On LD5, a reduction of the frequency of USVs was observed in pups, but no signs of inflammation were found. At weaning, an increase in immune system activity was observed, but no differences in open-field behavior were found. Conclusion: These results indicate that inflammation in lactating mothers disrupted mother/pup interactions and may have produced short- and long-term effects on pup behavior as well as biological pathways that modulate inflammatory responses to bacterial endotoxin challenge in pups. (C) 2014 S. Karger AG, Basel |
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Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male OffspringLactationMaternal careUltrasonic vocalizationInflammationImmune systemObjective: The present study analyzed the effects of lipopolysaccharide (LPS) on maternal behavior during lactation and possible correlations with changes in emotional and immune responses in offspring. Methods: Lactating rats received 100 mu g/kg LPS, and the control group received saline solution on lactation day (LD) 3. Maternal general activity and maternal behavior were observed on LD5 (i.e. the day that the peak of fever occurred). In male pups, hematological parameters and ultrasonic vocalizations (USVs) were assessed on LD5. At weaning, an additional dose of LPS (50 mu g/kg, i.p.) was administered in male pups, and open-field behavior, oxidative burst and phagocytosis were evaluated. Results: A reduction in the time in which dams retrieved the pups was observed, whereas no effects on maternal aggressive behavior were found. On LD5, a reduction of the frequency of USVs was observed in pups, but no signs of inflammation were found. At weaning, an increase in immune system activity was observed, but no differences in open-field behavior were found. Conclusion: These results indicate that inflammation in lactating mothers disrupted mother/pup interactions and may have produced short- and long-term effects on pup behavior as well as biological pathways that modulate inflammatory responses to bacterial endotoxin challenge in pups. (C) 2014 S. Karger AG, BaselFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo, BrazilUniv Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, Grad Program Dent, BR-04026002 Sao Paulo, SP, BrazilFed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, BrazilUniv Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, Grad Program Dent, BR-04026002 Sao Paulo, SP, BrazilFAPESP: 2013/03912-0FAPESP: 2009/51886-3KargerUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Universidade Federal do ABC (UFABC)Nascimento, Amanda F.Alves, Glaucie JussilaneMassoco, Cristina O.Teodorov, ElizabethFelicio, Luciano F.Bernardi, Maria Martha [UNESP]2018-11-26T15:27:34Z2018-11-26T15:27:34Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article213-221application/pdfhttp://dx.doi.org/10.1159/000363350Neuroimmunomodulation. Basel: Karger, v. 22, n. 4, p. 213-221, 2015.1021-7401http://hdl.handle.net/11449/15841610.1159/000363350WOS:000353564000001WOS000353564000001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeuroimmunomodulation1,064info:eu-repo/semantics/openAccess2023-12-12T06:24:38Zoai:repositorio.unesp.br:11449/158416Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:11:26.551264Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
title |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
spellingShingle |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring Nascimento, Amanda F. Lactation Maternal care Ultrasonic vocalization Inflammation Immune system |
title_short |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
title_full |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
title_fullStr |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
title_full_unstemmed |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
title_sort |
Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring |
author |
Nascimento, Amanda F. |
author_facet |
Nascimento, Amanda F. Alves, Glaucie Jussilane Massoco, Cristina O. Teodorov, Elizabeth Felicio, Luciano F. Bernardi, Maria Martha [UNESP] |
author_role |
author |
author2 |
Alves, Glaucie Jussilane Massoco, Cristina O. Teodorov, Elizabeth Felicio, Luciano F. Bernardi, Maria Martha [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Universidade Federal do ABC (UFABC) |
dc.contributor.author.fl_str_mv |
Nascimento, Amanda F. Alves, Glaucie Jussilane Massoco, Cristina O. Teodorov, Elizabeth Felicio, Luciano F. Bernardi, Maria Martha [UNESP] |
dc.subject.por.fl_str_mv |
Lactation Maternal care Ultrasonic vocalization Inflammation Immune system |
topic |
Lactation Maternal care Ultrasonic vocalization Inflammation Immune system |
description |
Objective: The present study analyzed the effects of lipopolysaccharide (LPS) on maternal behavior during lactation and possible correlations with changes in emotional and immune responses in offspring. Methods: Lactating rats received 100 mu g/kg LPS, and the control group received saline solution on lactation day (LD) 3. Maternal general activity and maternal behavior were observed on LD5 (i.e. the day that the peak of fever occurred). In male pups, hematological parameters and ultrasonic vocalizations (USVs) were assessed on LD5. At weaning, an additional dose of LPS (50 mu g/kg, i.p.) was administered in male pups, and open-field behavior, oxidative burst and phagocytosis were evaluated. Results: A reduction in the time in which dams retrieved the pups was observed, whereas no effects on maternal aggressive behavior were found. On LD5, a reduction of the frequency of USVs was observed in pups, but no signs of inflammation were found. At weaning, an increase in immune system activity was observed, but no differences in open-field behavior were found. Conclusion: These results indicate that inflammation in lactating mothers disrupted mother/pup interactions and may have produced short- and long-term effects on pup behavior as well as biological pathways that modulate inflammatory responses to bacterial endotoxin challenge in pups. (C) 2014 S. Karger AG, Basel |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-11-26T15:27:34Z 2018-11-26T15:27:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000363350 Neuroimmunomodulation. Basel: Karger, v. 22, n. 4, p. 213-221, 2015. 1021-7401 http://hdl.handle.net/11449/158416 10.1159/000363350 WOS:000353564000001 WOS000353564000001.pdf |
url |
http://dx.doi.org/10.1159/000363350 http://hdl.handle.net/11449/158416 |
identifier_str_mv |
Neuroimmunomodulation. Basel: Karger, v. 22, n. 4, p. 213-221, 2015. 1021-7401 10.1159/000363350 WOS:000353564000001 WOS000353564000001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuroimmunomodulation 1,064 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
213-221 application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129170331402240 |