Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/MD.0000000000012304 http://hdl.handle.net/11449/188159 |
Resumo: | The aim of this retrospective cross-sectional study was to assess the usefulness of phosphase and tensin homolog deleted on chromosome 10 (PTEN) and p53 protein immunoexpression in predicting the risk of malignancy in endometrial polyps. The study was conducted at tertiary public hospital, university teaching center, and private practice clinic. A total of 159 patients with endometrial polyps who underwent hysteroscopic polypectomy between January 2010 to December 2014 were included. p53 and PTEN immunoexpression were assessed in histologic endometrial polyp samples. Patients were allocated into 2 groups: group A, endometrial polyps without atypia (120), and group B, endometrial polyps with atypia (39), which were subdivided into A1 (80) and B1 (21) = p53-/PTEN+ immunostaining; A2 (20) and B2 (11) = p53+/PTEN+; A3 (14) and B3 (4) = p53+/PTEN-; A4 (6) and B4 (3) = p53-/PTEN-. There was no significant difference between groups regarding clinical and epidemiologic parameters, except for age. Neoplasia incidence within groups was higher when at least 1 marker was abnormally stained (in group A, P=.0089, odds ratio [OR]=13.94 [1.62; 120.27]; in group B, P=.0255, OR 12.73 [1.38; 117.27]). Overall neoplasia incidence was higher in group B than in group A (20.5% vs 5.8%; P=.0113). Malignant neoplasia was found more frequently in patients with p53+ (P=.0006, OR=7.67 [2.30; 25.54]) and PTEN- (P=.0043; OR=5.43 [1.77; 16.61]). Immunohistochemical analysis using p53 and PTEN as markers, either alone or concomitantly, can be useful to predict malignant transformation in cases of endometrial polyps. |
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Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polypsHysteroscopyImmunohistochemistryPolypsPTEN phosphohydrolaseTumor suppressor p53 proteinThe aim of this retrospective cross-sectional study was to assess the usefulness of phosphase and tensin homolog deleted on chromosome 10 (PTEN) and p53 protein immunoexpression in predicting the risk of malignancy in endometrial polyps. The study was conducted at tertiary public hospital, university teaching center, and private practice clinic. A total of 159 patients with endometrial polyps who underwent hysteroscopic polypectomy between January 2010 to December 2014 were included. p53 and PTEN immunoexpression were assessed in histologic endometrial polyp samples. Patients were allocated into 2 groups: group A, endometrial polyps without atypia (120), and group B, endometrial polyps with atypia (39), which were subdivided into A1 (80) and B1 (21) = p53-/PTEN+ immunostaining; A2 (20) and B2 (11) = p53+/PTEN+; A3 (14) and B3 (4) = p53+/PTEN-; A4 (6) and B4 (3) = p53-/PTEN-. There was no significant difference between groups regarding clinical and epidemiologic parameters, except for age. Neoplasia incidence within groups was higher when at least 1 marker was abnormally stained (in group A, P=.0089, odds ratio [OR]=13.94 [1.62; 120.27]; in group B, P=.0255, OR 12.73 [1.38; 117.27]). Overall neoplasia incidence was higher in group B than in group A (20.5% vs 5.8%; P=.0113). Malignant neoplasia was found more frequently in patients with p53+ (P=.0006, OR=7.67 [2.30; 25.54]) and PTEN- (P=.0043; OR=5.43 [1.77; 16.61]). Immunohistochemical analysis using p53 and PTEN as markers, either alone or concomitantly, can be useful to predict malignant transformation in cases of endometrial polyps.Department of Gynecology and Obstetrics of Hospital Beneficente Unimar - HBU University of Marília UNIMAR Medical SchoolMedical Assistance Institute - IAMDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University/UNESPDepartment of Pathological Anatomy Botucatu Medical School São Paulo State University/UNESPDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University/UNESPDepartment of Pathological Anatomy Botucatu Medical School São Paulo State University/UNESPUNIMAR Medical SchoolMedical Assistance Institute - IAMUniversidade Estadual Paulista (Unesp)Abrão, FéresModotti, Waldir Pereira [UNESP]Spadoto-Dias, Daniel [UNESP]Bueloni-Dias, Flávia Neves [UNESP]Leite, Nilton José [UNESP]Peres, Gustavo Filipov [UNESP]Elias, Leonardo Vieira [UNESP]Custódio Domingues, Maria Aparecida [UNESP]Dias, Rogério [UNESP]2019-10-06T15:59:12Z2019-10-06T15:59:12Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1097/MD.0000000000012304Medicine (United States), v. 97, n. 38, 2018.1536-59640025-7974http://hdl.handle.net/11449/18815910.1097/MD.00000000000123042-s2.0-85054443591Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedicine (United States)info:eu-repo/semantics/openAccess2024-09-03T13:14:43Zoai:repositorio.unesp.br:11449/188159Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
title |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
spellingShingle |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps Abrão, Féres Hysteroscopy Immunohistochemistry Polyps PTEN phosphohydrolase Tumor suppressor p53 protein |
title_short |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
title_full |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
title_fullStr |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
title_full_unstemmed |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
title_sort |
Concomitant p53 and PTEN immunoexpression to predict the risk of malignancy in endometrial polyps |
author |
Abrão, Féres |
author_facet |
Abrão, Féres Modotti, Waldir Pereira [UNESP] Spadoto-Dias, Daniel [UNESP] Bueloni-Dias, Flávia Neves [UNESP] Leite, Nilton José [UNESP] Peres, Gustavo Filipov [UNESP] Elias, Leonardo Vieira [UNESP] Custódio Domingues, Maria Aparecida [UNESP] Dias, Rogério [UNESP] |
author_role |
author |
author2 |
Modotti, Waldir Pereira [UNESP] Spadoto-Dias, Daniel [UNESP] Bueloni-Dias, Flávia Neves [UNESP] Leite, Nilton José [UNESP] Peres, Gustavo Filipov [UNESP] Elias, Leonardo Vieira [UNESP] Custódio Domingues, Maria Aparecida [UNESP] Dias, Rogério [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
UNIMAR Medical School Medical Assistance Institute - IAM Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Abrão, Féres Modotti, Waldir Pereira [UNESP] Spadoto-Dias, Daniel [UNESP] Bueloni-Dias, Flávia Neves [UNESP] Leite, Nilton José [UNESP] Peres, Gustavo Filipov [UNESP] Elias, Leonardo Vieira [UNESP] Custódio Domingues, Maria Aparecida [UNESP] Dias, Rogério [UNESP] |
dc.subject.por.fl_str_mv |
Hysteroscopy Immunohistochemistry Polyps PTEN phosphohydrolase Tumor suppressor p53 protein |
topic |
Hysteroscopy Immunohistochemistry Polyps PTEN phosphohydrolase Tumor suppressor p53 protein |
description |
The aim of this retrospective cross-sectional study was to assess the usefulness of phosphase and tensin homolog deleted on chromosome 10 (PTEN) and p53 protein immunoexpression in predicting the risk of malignancy in endometrial polyps. The study was conducted at tertiary public hospital, university teaching center, and private practice clinic. A total of 159 patients with endometrial polyps who underwent hysteroscopic polypectomy between January 2010 to December 2014 were included. p53 and PTEN immunoexpression were assessed in histologic endometrial polyp samples. Patients were allocated into 2 groups: group A, endometrial polyps without atypia (120), and group B, endometrial polyps with atypia (39), which were subdivided into A1 (80) and B1 (21) = p53-/PTEN+ immunostaining; A2 (20) and B2 (11) = p53+/PTEN+; A3 (14) and B3 (4) = p53+/PTEN-; A4 (6) and B4 (3) = p53-/PTEN-. There was no significant difference between groups regarding clinical and epidemiologic parameters, except for age. Neoplasia incidence within groups was higher when at least 1 marker was abnormally stained (in group A, P=.0089, odds ratio [OR]=13.94 [1.62; 120.27]; in group B, P=.0255, OR 12.73 [1.38; 117.27]). Overall neoplasia incidence was higher in group B than in group A (20.5% vs 5.8%; P=.0113). Malignant neoplasia was found more frequently in patients with p53+ (P=.0006, OR=7.67 [2.30; 25.54]) and PTEN- (P=.0043; OR=5.43 [1.77; 16.61]). Immunohistochemical analysis using p53 and PTEN as markers, either alone or concomitantly, can be useful to predict malignant transformation in cases of endometrial polyps. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 2019-10-06T15:59:12Z 2019-10-06T15:59:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/MD.0000000000012304 Medicine (United States), v. 97, n. 38, 2018. 1536-5964 0025-7974 http://hdl.handle.net/11449/188159 10.1097/MD.0000000000012304 2-s2.0-85054443591 |
url |
http://dx.doi.org/10.1097/MD.0000000000012304 http://hdl.handle.net/11449/188159 |
identifier_str_mv |
Medicine (United States), v. 97, n. 38, 2018. 1536-5964 0025-7974 10.1097/MD.0000000000012304 2-s2.0-85054443591 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medicine (United States) |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021372901982208 |