α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/0306-3623(93)90362-2 http://hdl.handle.net/11449/230879 |
Resumo: | 1. The effects of chlorethylclonidine (CEC), 5-methyl-urapidil (5-MU), ryanodine and prolonged exposition to norepinephrine (NE) on the concentration-response curves (CRC) to this agonist on the bisected rat vas deferens (RVD) were investigated. 2. CEC did not affect the 50% effective concentration (EC50) of NE in either the prostatic (PP) or the epididymal (EP) portions of the RVD. 3. 5-MU did not alter the EC50 of NE in the PP but caused a significant and concentration-dependent rightward shift of the CRC to NE in the EP. 4. Ryanodine caused a shift to the right of the CRC to NE in the PP associated to a decrease in maximal response, but did not affect the CRC to NE in the EP. 5. Incubation of the EP with NE for 6 hr elicited a significant decrease in the maximal response with no changes in the EC50. Similar treatment of the PP was associated with a significant shift to the right of the CRC to NE without modifications in the maximal response. 6. These results suggest that in the RVD, NE interacts with two different α1-adrenoceptors subtypes which are disposed in a selective manner along the RVD: the α1a subtype in the EP, and a non-α1b-non-α1a adrenoceptor subtype mainly located at the PP. © 1993. |
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α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens1. The effects of chlorethylclonidine (CEC), 5-methyl-urapidil (5-MU), ryanodine and prolonged exposition to norepinephrine (NE) on the concentration-response curves (CRC) to this agonist on the bisected rat vas deferens (RVD) were investigated. 2. CEC did not affect the 50% effective concentration (EC50) of NE in either the prostatic (PP) or the epididymal (EP) portions of the RVD. 3. 5-MU did not alter the EC50 of NE in the PP but caused a significant and concentration-dependent rightward shift of the CRC to NE in the EP. 4. Ryanodine caused a shift to the right of the CRC to NE in the PP associated to a decrease in maximal response, but did not affect the CRC to NE in the EP. 5. Incubation of the EP with NE for 6 hr elicited a significant decrease in the maximal response with no changes in the EC50. Similar treatment of the PP was associated with a significant shift to the right of the CRC to NE without modifications in the maximal response. 6. These results suggest that in the RVD, NE interacts with two different α1-adrenoceptors subtypes which are disposed in a selective manner along the RVD: the α1a subtype in the EP, and a non-α1b-non-α1a adrenoceptor subtype mainly located at the PP. © 1993.Department of Animal Morphology and Physiology, Faculty of Agronomic and Veterinary Sciences, University of São Paulo State-UNESP, Jaboticabal, 14870-000, Brazil [Fax (0163) 22-4275]Faculty of Medicine of Ribeirão Preto, University of São Paulo-USP, Ribeirão PretoUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Queiroz-Neto, AntonioBallejo, Gustavo2022-04-29T08:42:27Z2022-04-29T08:42:27Z1993-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1149-1153http://dx.doi.org/10.1016/0306-3623(93)90362-2General Pharmacology, v. 24, n. 5, p. 1149-1153, 1993.0306-3623http://hdl.handle.net/11449/23087910.1016/0306-3623(93)90362-22-s2.0-0027205622Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGeneral Pharmacologyinfo:eu-repo/semantics/openAccess2024-06-06T18:42:12Zoai:repositorio.unesp.br:11449/230879Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:32:44.480707Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
title |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
spellingShingle |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens Queiroz-Neto, Antonio |
title_short |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
title_full |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
title_fullStr |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
title_full_unstemmed |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
title_sort |
α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens |
author |
Queiroz-Neto, Antonio |
author_facet |
Queiroz-Neto, Antonio Ballejo, Gustavo |
author_role |
author |
author2 |
Ballejo, Gustavo |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Queiroz-Neto, Antonio Ballejo, Gustavo |
description |
1. The effects of chlorethylclonidine (CEC), 5-methyl-urapidil (5-MU), ryanodine and prolonged exposition to norepinephrine (NE) on the concentration-response curves (CRC) to this agonist on the bisected rat vas deferens (RVD) were investigated. 2. CEC did not affect the 50% effective concentration (EC50) of NE in either the prostatic (PP) or the epididymal (EP) portions of the RVD. 3. 5-MU did not alter the EC50 of NE in the PP but caused a significant and concentration-dependent rightward shift of the CRC to NE in the EP. 4. Ryanodine caused a shift to the right of the CRC to NE in the PP associated to a decrease in maximal response, but did not affect the CRC to NE in the EP. 5. Incubation of the EP with NE for 6 hr elicited a significant decrease in the maximal response with no changes in the EC50. Similar treatment of the PP was associated with a significant shift to the right of the CRC to NE without modifications in the maximal response. 6. These results suggest that in the RVD, NE interacts with two different α1-adrenoceptors subtypes which are disposed in a selective manner along the RVD: the α1a subtype in the EP, and a non-α1b-non-α1a adrenoceptor subtype mainly located at the PP. © 1993. |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-01-01 2022-04-29T08:42:27Z 2022-04-29T08:42:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/0306-3623(93)90362-2 General Pharmacology, v. 24, n. 5, p. 1149-1153, 1993. 0306-3623 http://hdl.handle.net/11449/230879 10.1016/0306-3623(93)90362-2 2-s2.0-0027205622 |
url |
http://dx.doi.org/10.1016/0306-3623(93)90362-2 http://hdl.handle.net/11449/230879 |
identifier_str_mv |
General Pharmacology, v. 24, n. 5, p. 1149-1153, 1993. 0306-3623 10.1016/0306-3623(93)90362-2 2-s2.0-0027205622 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
General Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1149-1153 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129217563459584 |