Mandibular cortical bone evaluation on cone beam computed tomography images of patients with bisphosphonate-related osteonecrosis of the jaw

• Autor(a) principal: Torres, Sandra R.
• Data de Publicação: 2012
• Outros Autores: Chen, Curtis S. K., Leroux, Brian G., Lee, Peggy P., Hollender, Lars G., Santos, Eduardo C. A. [UNESP], Drew, Shane P., Hung, Kuei-Ching, Schubert, Mark M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.oooo.2011.11.011; http://hdl.handle.net/11449/42641

Objectives. The objective of this study was to develop a technique for detecting cortical bone dimensional changes in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ).Study Design. Subjects with BRONJ who had cone-beam computed tomography imaging were selected, with age- and gender-matched controls. Mandibular cortical bone measurements to detect bisphosphonate-related cortical bone changes were made inferior to mental foramen, in 3 different ways: within a fixed sized rectangle, in a rectangle varying with the cortical height, and a ratio between area and height.Results. Twelve BRONJ cases and 66 controls were evaluated. The cortical bone measurements were significantly higher in cases than controls for all 3 techniques. The bone measurements were strongly associated with BRONJ case status (odds ratio 3.36-7.84). The inter-rater reliability coefficients were high for all techniques (0.71-0.90).Conclusions. Mandibular cortical bone measurement is a potentially useful tool in the detection of bone dimensional changes caused by bisphosphonates. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:695-703)