Clinical, biomechanical and histological study on oophorectomy induced menopause
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1413-78522014220500420 http://hdl.handle.net/11449/114313 |
Resumo: | Objective:To investigate the clinical implications as well as biomechanical and histological changes and in bone tissue induced by ovariectomy in 64 rats.Methods:The rats were divided into two groups: bilateral oophorectomy or placebo, and subdivided into four subgroups, according to time postoperatively: three, six, nine and 12 months. The weight of the animals at the time of sacrifice was taken into consideration. The biomechanical study was performed on the right tibia, to the maximum load and stiffness coefficient. For the histological study we calculated the trabecular bone of the left tibia. Statistical analysis of body weight and mechanical properties was performed by variance analysis, complemented with Tukey's multiple comparison tests; and trabecular area, the non-parametric variance analysis.Results:Ovariectomy-induced menopause caused an increase in body weight, reduction of diaphyseal bone resistance at six months of hormone deprivation, but this effect is equalized over time by aging; bone stiffness was smaller in the ovariectomized group and reduction of bone mass occurred.Conclusion:The removal of the ovaries produced systemic alterations, characterized by metabolic changes that caused weight gain and changes in bone tissue, associated with alteration of the mechanical profile and reduced bone mass. Level of Evidence I, Clinical Study. |
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Clinical, biomechanical and histological study on oophorectomy induced menopauseOvariectomyRatsFemaleBiomechanicsHistologyOsteoporosis, postmenopausalObjective:To investigate the clinical implications as well as biomechanical and histological changes and in bone tissue induced by ovariectomy in 64 rats.Methods:The rats were divided into two groups: bilateral oophorectomy or placebo, and subdivided into four subgroups, according to time postoperatively: three, six, nine and 12 months. The weight of the animals at the time of sacrifice was taken into consideration. The biomechanical study was performed on the right tibia, to the maximum load and stiffness coefficient. For the histological study we calculated the trabecular bone of the left tibia. Statistical analysis of body weight and mechanical properties was performed by variance analysis, complemented with Tukey's multiple comparison tests; and trabecular area, the non-parametric variance analysis.Results:Ovariectomy-induced menopause caused an increase in body weight, reduction of diaphyseal bone resistance at six months of hormone deprivation, but this effect is equalized over time by aging; bone stiffness was smaller in the ovariectomized group and reduction of bone mass occurred.Conclusion:The removal of the ovaries produced systemic alterations, characterized by metabolic changes that caused weight gain and changes in bone tissue, associated with alteration of the mechanical profile and reduced bone mass. Level of Evidence I, Clinical Study.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Faculdades Adamantinenses IntegradasUniversidade Estadual Paulista Faculdade de Medicina de BotucatuUniversidade Estadual Paulista Faculdade de Medicina de BotucatuSociedade Brasileira de Ortopedia e TraumatologiaFaculdades Adamantinenses IntegradasUniversidade Estadual Paulista (Unesp)Bordinhon, MaristelaMüller, Sérgio SwainSilva, Maeli Dal Pai2015-02-02T12:39:26Z2015-02-02T12:39:26Z2014-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article260-263application/pdfhttp://dx.doi.org/10.1590/1413-78522014220500420Acta Ortopédica Brasileira. Sociedade Brasileira de Ortopedia e Traumatologia, v. 22, n. 5, p. 260-263, 2014.1413-7852http://hdl.handle.net/11449/11431310.1590/1413-78522014220500420S1413-78522014000500260S1413-78522014000500260.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Ortopédica Brasileira0.5460,343info:eu-repo/semantics/openAccess2024-08-14T14:18:40Zoai:repositorio.unesp.br:11449/114313Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T14:18:40Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
title |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
spellingShingle |
Clinical, biomechanical and histological study on oophorectomy induced menopause Bordinhon, Maristela Ovariectomy Rats Female Biomechanics Histology Osteoporosis, postmenopausal |
title_short |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
title_full |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
title_fullStr |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
title_full_unstemmed |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
title_sort |
Clinical, biomechanical and histological study on oophorectomy induced menopause |
author |
Bordinhon, Maristela |
author_facet |
Bordinhon, Maristela Müller, Sérgio Swain Silva, Maeli Dal Pai |
author_role |
author |
author2 |
Müller, Sérgio Swain Silva, Maeli Dal Pai |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Faculdades Adamantinenses Integradas Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bordinhon, Maristela Müller, Sérgio Swain Silva, Maeli Dal Pai |
dc.subject.por.fl_str_mv |
Ovariectomy Rats Female Biomechanics Histology Osteoporosis, postmenopausal |
topic |
Ovariectomy Rats Female Biomechanics Histology Osteoporosis, postmenopausal |
description |
Objective:To investigate the clinical implications as well as biomechanical and histological changes and in bone tissue induced by ovariectomy in 64 rats.Methods:The rats were divided into two groups: bilateral oophorectomy or placebo, and subdivided into four subgroups, according to time postoperatively: three, six, nine and 12 months. The weight of the animals at the time of sacrifice was taken into consideration. The biomechanical study was performed on the right tibia, to the maximum load and stiffness coefficient. For the histological study we calculated the trabecular bone of the left tibia. Statistical analysis of body weight and mechanical properties was performed by variance analysis, complemented with Tukey's multiple comparison tests; and trabecular area, the non-parametric variance analysis.Results:Ovariectomy-induced menopause caused an increase in body weight, reduction of diaphyseal bone resistance at six months of hormone deprivation, but this effect is equalized over time by aging; bone stiffness was smaller in the ovariectomized group and reduction of bone mass occurred.Conclusion:The removal of the ovaries produced systemic alterations, characterized by metabolic changes that caused weight gain and changes in bone tissue, associated with alteration of the mechanical profile and reduced bone mass. Level of Evidence I, Clinical Study. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-01 2015-02-02T12:39:26Z 2015-02-02T12:39:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1413-78522014220500420 Acta Ortopédica Brasileira. Sociedade Brasileira de Ortopedia e Traumatologia, v. 22, n. 5, p. 260-263, 2014. 1413-7852 http://hdl.handle.net/11449/114313 10.1590/1413-78522014220500420 S1413-78522014000500260 S1413-78522014000500260.pdf |
url |
http://dx.doi.org/10.1590/1413-78522014220500420 http://hdl.handle.net/11449/114313 |
identifier_str_mv |
Acta Ortopédica Brasileira. Sociedade Brasileira de Ortopedia e Traumatologia, v. 22, n. 5, p. 260-263, 2014. 1413-7852 10.1590/1413-78522014220500420 S1413-78522014000500260 S1413-78522014000500260.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Ortopédica Brasileira 0.546 0,343 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
260-263 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128127027642368 |