Anti-inflammatory drug design by molecular hybridization approach
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ph4111450 http://hdl.handle.net/11449/133761 |
Resumo: | The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach. |
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Repositório Institucional da UNESP |
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Anti-inflammatory drug design by molecular hybridization approachAnti-inflammatoryHybridizationMultiple-ligandsMutual prodrugThe design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Pesquisa (CNPq)Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, BrasilFAPESP: 2010/12495-6FAPESP: 2010/50330-9CNPq: 308157/2010-9Universidade Estadual Paulista (Unesp)Bosquesi, Priscila Longhin [UNESP]Melo, Tais Regina Ferreira [UNESP]Vizioli, Ednir de Oliveira [UNESP]Santos, Jean Leandro dos [UNESP]Chung, Man Chin [UNESP]2016-01-28T16:56:31Z2016-01-28T16:56:31Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1450-1474application/pdfhttp://dx.doi.org/10.3390/ph4111450Pharmaceuticals, v. 4, p. 1450-1474, 2011.1424-8247http://hdl.handle.net/11449/13376110.3390/ph4111450ISSN1424-8247-2011-04-1450-1474.pdf408306821062366332042770433661195435899068903487973433360797541357379336395169440000-0003-4141-0455Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticals1,293info:eu-repo/semantics/openAccess2024-06-24T13:46:11Zoai:repositorio.unesp.br:11449/133761Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:49:07.382725Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-inflammatory drug design by molecular hybridization approach |
title |
Anti-inflammatory drug design by molecular hybridization approach |
spellingShingle |
Anti-inflammatory drug design by molecular hybridization approach Bosquesi, Priscila Longhin [UNESP] Anti-inflammatory Hybridization Multiple-ligands Mutual prodrug |
title_short |
Anti-inflammatory drug design by molecular hybridization approach |
title_full |
Anti-inflammatory drug design by molecular hybridization approach |
title_fullStr |
Anti-inflammatory drug design by molecular hybridization approach |
title_full_unstemmed |
Anti-inflammatory drug design by molecular hybridization approach |
title_sort |
Anti-inflammatory drug design by molecular hybridization approach |
author |
Bosquesi, Priscila Longhin [UNESP] |
author_facet |
Bosquesi, Priscila Longhin [UNESP] Melo, Tais Regina Ferreira [UNESP] Vizioli, Ednir de Oliveira [UNESP] Santos, Jean Leandro dos [UNESP] Chung, Man Chin [UNESP] |
author_role |
author |
author2 |
Melo, Tais Regina Ferreira [UNESP] Vizioli, Ednir de Oliveira [UNESP] Santos, Jean Leandro dos [UNESP] Chung, Man Chin [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bosquesi, Priscila Longhin [UNESP] Melo, Tais Regina Ferreira [UNESP] Vizioli, Ednir de Oliveira [UNESP] Santos, Jean Leandro dos [UNESP] Chung, Man Chin [UNESP] |
dc.subject.por.fl_str_mv |
Anti-inflammatory Hybridization Multiple-ligands Mutual prodrug |
topic |
Anti-inflammatory Hybridization Multiple-ligands Mutual prodrug |
description |
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2016-01-28T16:56:31Z 2016-01-28T16:56:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ph4111450 Pharmaceuticals, v. 4, p. 1450-1474, 2011. 1424-8247 http://hdl.handle.net/11449/133761 10.3390/ph4111450 ISSN1424-8247-2011-04-1450-1474.pdf 4083068210623663 3204277043366119 5435899068903487 9734333607975413 5737933639516944 0000-0003-4141-0455 |
url |
http://dx.doi.org/10.3390/ph4111450 http://hdl.handle.net/11449/133761 |
identifier_str_mv |
Pharmaceuticals, v. 4, p. 1450-1474, 2011. 1424-8247 10.3390/ph4111450 ISSN1424-8247-2011-04-1450-1474.pdf 4083068210623663 3204277043366119 5435899068903487 9734333607975413 5737933639516944 0000-0003-4141-0455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceuticals 1,293 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1450-1474 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129252707532800 |