Studies of natural killer cells in pregnancy-induced hypertension.
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224007 |
Resumo: | The number and activity of natural killer (NK) cells were studied in 20 patients with pregnancy-induced hypertension (PIH), 15 uncomplicated pregnant women and 16 healthy non-pregnant women. All the pregnant women were primigravidae and were evaluated during the third trimester of gestation. Peripheral blood NK cells were detected with monoclonal antibodies by indirect immunofluorescence and cytotoxic activity was measured using a single-cell assay against K562 target cells. Hypertensive pregnant women had an increased number of circulating NK cells associated with a significant decrease of NK activity. The cytotoxic activity was significantly lower in normal pregnant and PIH women when compared with non-pregnant controls. The onset of immature NK cells in peripheral blood and the impairment of their cytotoxic activity in PIH patients may be associated with hormones and immunosuppressive substances produced by tissues occurring at the maternal-fetal interface. |
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Repositório Institucional da UNESP |
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spelling |
Studies of natural killer cells in pregnancy-induced hypertension.The number and activity of natural killer (NK) cells were studied in 20 patients with pregnancy-induced hypertension (PIH), 15 uncomplicated pregnant women and 16 healthy non-pregnant women. All the pregnant women were primigravidae and were evaluated during the third trimester of gestation. Peripheral blood NK cells were detected with monoclonal antibodies by indirect immunofluorescence and cytotoxic activity was measured using a single-cell assay against K562 target cells. Hypertensive pregnant women had an increased number of circulating NK cells associated with a significant decrease of NK activity. The cytotoxic activity was significantly lower in normal pregnant and PIH women when compared with non-pregnant controls. The onset of immature NK cells in peripheral blood and the impairment of their cytotoxic activity in PIH patients may be associated with hormones and immunosuppressive substances produced by tissues occurring at the maternal-fetal interface.Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista SPDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista SPUniversidade Estadual Paulista (UNESP)Peraçoli, J. C. [UNESP]Fortes, M. R. [UNESP]Rudge, M. V. [UNESP]Rezkallah-Iwasso, M. T. [UNESP]Peraçoli, M. T. [UNESP]2022-04-28T19:54:17Z2022-04-28T19:54:17Z1995-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article655-661Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 28, n. 6, p. 655-661, 1995.0100-879Xhttp://hdl.handle.net/11449/2240072-s2.0-0029312756Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]info:eu-repo/semantics/openAccess2024-08-16T14:12:39Zoai:repositorio.unesp.br:11449/224007Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Studies of natural killer cells in pregnancy-induced hypertension. |
title |
Studies of natural killer cells in pregnancy-induced hypertension. |
spellingShingle |
Studies of natural killer cells in pregnancy-induced hypertension. Peraçoli, J. C. [UNESP] |
title_short |
Studies of natural killer cells in pregnancy-induced hypertension. |
title_full |
Studies of natural killer cells in pregnancy-induced hypertension. |
title_fullStr |
Studies of natural killer cells in pregnancy-induced hypertension. |
title_full_unstemmed |
Studies of natural killer cells in pregnancy-induced hypertension. |
title_sort |
Studies of natural killer cells in pregnancy-induced hypertension. |
author |
Peraçoli, J. C. [UNESP] |
author_facet |
Peraçoli, J. C. [UNESP] Fortes, M. R. [UNESP] Rudge, M. V. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] Peraçoli, M. T. [UNESP] |
author_role |
author |
author2 |
Fortes, M. R. [UNESP] Rudge, M. V. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] Peraçoli, M. T. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Peraçoli, J. C. [UNESP] Fortes, M. R. [UNESP] Rudge, M. V. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] Peraçoli, M. T. [UNESP] |
description |
The number and activity of natural killer (NK) cells were studied in 20 patients with pregnancy-induced hypertension (PIH), 15 uncomplicated pregnant women and 16 healthy non-pregnant women. All the pregnant women were primigravidae and were evaluated during the third trimester of gestation. Peripheral blood NK cells were detected with monoclonal antibodies by indirect immunofluorescence and cytotoxic activity was measured using a single-cell assay against K562 target cells. Hypertensive pregnant women had an increased number of circulating NK cells associated with a significant decrease of NK activity. The cytotoxic activity was significantly lower in normal pregnant and PIH women when compared with non-pregnant controls. The onset of immature NK cells in peripheral blood and the impairment of their cytotoxic activity in PIH patients may be associated with hormones and immunosuppressive substances produced by tissues occurring at the maternal-fetal interface. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01 2022-04-28T19:54:17Z 2022-04-28T19:54:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 28, n. 6, p. 655-661, 1995. 0100-879X http://hdl.handle.net/11449/224007 2-s2.0-0029312756 |
identifier_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 28, n. 6, p. 655-661, 1995. 0100-879X 2-s2.0-0029312756 |
url |
http://hdl.handle.net/11449/224007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
655-661 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128186758725632 |