FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2018/3920810 http://hdl.handle.net/11449/186477 |
Resumo: | Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815-1736 cm(-1), and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5-1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug. |
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Repositório Institucional da UNESP |
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FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to AmoxicillinAmoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815-1736 cm(-1), and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5-1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.PACD-FCFAr-UNESP (Araraquara, Brazil)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilMartin Luther Univ Halle Wittenberg, Fac Nat Sci 1, Inst Biochem & Biotechnol, Halle, Saale, GermanyUniv Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilHindawi LtdUniversidade Estadual Paulista (Unesp)Martin Luther Univ Halle WittenbergFanelli, Stefany [UNESP]Zimmermann, AlexanderTotoli, Eliane Gandolpho [UNESP]Nunes Salgado, Herida Regina [UNESP]2019-10-05T01:12:14Z2019-10-05T01:12:14Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8http://dx.doi.org/10.1155/2018/3920810Journal Of Chemistry. London: Hindawi Ltd, 8 p., 2018.2090-9063http://hdl.handle.net/11449/18647710.1155/2018/3920810WOS:000449322600001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Chemistryinfo:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/186477Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:42:21.492389Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
title |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
spellingShingle |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin Fanelli, Stefany [UNESP] |
title_short |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
title_full |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
title_fullStr |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
title_full_unstemmed |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
title_sort |
FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
author |
Fanelli, Stefany [UNESP] |
author_facet |
Fanelli, Stefany [UNESP] Zimmermann, Alexander Totoli, Eliane Gandolpho [UNESP] Nunes Salgado, Herida Regina [UNESP] |
author_role |
author |
author2 |
Zimmermann, Alexander Totoli, Eliane Gandolpho [UNESP] Nunes Salgado, Herida Regina [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Martin Luther Univ Halle Wittenberg |
dc.contributor.author.fl_str_mv |
Fanelli, Stefany [UNESP] Zimmermann, Alexander Totoli, Eliane Gandolpho [UNESP] Nunes Salgado, Herida Regina [UNESP] |
description |
Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815-1736 cm(-1), and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5-1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2019-10-05T01:12:14Z 2019-10-05T01:12:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2018/3920810 Journal Of Chemistry. London: Hindawi Ltd, 8 p., 2018. 2090-9063 http://hdl.handle.net/11449/186477 10.1155/2018/3920810 WOS:000449322600001 |
url |
http://dx.doi.org/10.1155/2018/3920810 http://hdl.handle.net/11449/186477 |
identifier_str_mv |
Journal Of Chemistry. London: Hindawi Ltd, 8 p., 2018. 2090-9063 10.1155/2018/3920810 WOS:000449322600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8 |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129349106270208 |