Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Cavassan, Nayara Rodrigues Vieira [UNESP]
Data de Publicação: 2019
Outros Autores: Camargo, Caio Cavassan [UNESP], de Pontes, Letícia Gomes [UNESP], Barraviera, Benedito [UNESP], Ferreira, Rui Seabra [UNESP], Miot, Hélio Amante [UNESP], Abbade, Luciana Patrícia Fernandes [UNESP], dos Santos, Lucilene Delazari [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jprot.2018.09.009
http://hdl.handle.net/11449/188162
Resumo: Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Twenty-three patients were female (62.2%), and five (37.8%) were male. The patients had a mean age of 70 (±10.1) years. Of the patients, 73% adhered to compression and rest, 81.1% reported a history of primary varices, 54.1% reported a history of systemic arterial hypertension, 54.1% reported a history of devitalized tissue in the wound bed and 64.9% reported ulcers with more than ten years of evolution. Seventy-six proteins were identified, and they were grouped according to their primary role in the healing process. Eight correlations between clinical and epidemiological data and protein expression were noteworthy: diabetes mellitus vs. Ig gamma-2 and apolipoprotein-A1 and albumin; congestive heart failure vs. Ig lambda-2; colonization vs. actin; compressive therapy vs. Ig kappa; systemic arterial hypertension vs. alpha-2-macroglobulin and apolipoprotein-A1; area of ulcer vs. apolipoprotein-A1; race vs. heavy chain Ig and Ig γ-1 chain; age and race vs. Ig γ-1 chain. These associations may help to elucidate the prognosis and chronicity of chronic venous ulcers based on secreted proteins.
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spelling Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional studyChronic venous ulcersClinical proteomicsInflammatory exudateMass spectrometryChronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Twenty-three patients were female (62.2%), and five (37.8%) were male. The patients had a mean age of 70 (±10.1) years. Of the patients, 73% adhered to compression and rest, 81.1% reported a history of primary varices, 54.1% reported a history of systemic arterial hypertension, 54.1% reported a history of devitalized tissue in the wound bed and 64.9% reported ulcers with more than ten years of evolution. Seventy-six proteins were identified, and they were grouped according to their primary role in the healing process. Eight correlations between clinical and epidemiological data and protein expression were noteworthy: diabetes mellitus vs. Ig gamma-2 and apolipoprotein-A1 and albumin; congestive heart failure vs. Ig lambda-2; colonization vs. actin; compressive therapy vs. Ig kappa; systemic arterial hypertension vs. alpha-2-macroglobulin and apolipoprotein-A1; area of ulcer vs. apolipoprotein-A1; race vs. heavy chain Ig and Ig γ-1 chain; age and race vs. Ig γ-1 chain. These associations may help to elucidate the prognosis and chronicity of chronic venous ulcers based on secreted proteins.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Graduate Program in Tropical Diseases Botucatu Medical School (FMB) Sao Paulo State University (UNESP)Center for the Study of Venoms and Venomous Animals (CEVAP) Sao Paulo State University (UNESP)Department of Dermatology and Radiology Botucatu Medical School (FMB) Sao Paulo State University (UNESP)Graduate Program in Tropical Diseases Botucatu Medical School (FMB) Sao Paulo State University (UNESP)Center for the Study of Venoms and Venomous Animals (CEVAP) Sao Paulo State University (UNESP)Department of Dermatology and Radiology Botucatu Medical School (FMB) Sao Paulo State University (UNESP)FAPESP: 2014/13299-7Universidade Estadual Paulista (Unesp)Cavassan, Nayara Rodrigues Vieira [UNESP]Camargo, Caio Cavassan [UNESP]de Pontes, Letícia Gomes [UNESP]Barraviera, Benedito [UNESP]Ferreira, Rui Seabra [UNESP]Miot, Hélio Amante [UNESP]Abbade, Luciana Patrícia Fernandes [UNESP]dos Santos, Lucilene Delazari [UNESP]2019-10-06T15:59:18Z2019-10-06T15:59:18Z2019-02-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article280-290http://dx.doi.org/10.1016/j.jprot.2018.09.009Journal of Proteomics, v. 192, p. 280-290.1876-77371874-3919http://hdl.handle.net/11449/18816210.1016/j.jprot.2018.09.0092-s2.0-850544587188084974543029515Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Proteomicsinfo:eu-repo/semantics/openAccess2024-08-15T15:23:14Zoai:repositorio.unesp.br:11449/188162Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
title Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
spellingShingle Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
Cavassan, Nayara Rodrigues Vieira [UNESP]
Chronic venous ulcers
Clinical proteomics
Inflammatory exudate
Mass spectrometry
title_short Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
title_full Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
title_fullStr Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
title_full_unstemmed Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
title_sort Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
author Cavassan, Nayara Rodrigues Vieira [UNESP]
author_facet Cavassan, Nayara Rodrigues Vieira [UNESP]
Camargo, Caio Cavassan [UNESP]
de Pontes, Letícia Gomes [UNESP]
Barraviera, Benedito [UNESP]
Ferreira, Rui Seabra [UNESP]
Miot, Hélio Amante [UNESP]
Abbade, Luciana Patrícia Fernandes [UNESP]
dos Santos, Lucilene Delazari [UNESP]
author_role author
author2 Camargo, Caio Cavassan [UNESP]
de Pontes, Letícia Gomes [UNESP]
Barraviera, Benedito [UNESP]
Ferreira, Rui Seabra [UNESP]
Miot, Hélio Amante [UNESP]
Abbade, Luciana Patrícia Fernandes [UNESP]
dos Santos, Lucilene Delazari [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Cavassan, Nayara Rodrigues Vieira [UNESP]
Camargo, Caio Cavassan [UNESP]
de Pontes, Letícia Gomes [UNESP]
Barraviera, Benedito [UNESP]
Ferreira, Rui Seabra [UNESP]
Miot, Hélio Amante [UNESP]
Abbade, Luciana Patrícia Fernandes [UNESP]
dos Santos, Lucilene Delazari [UNESP]
dc.subject.por.fl_str_mv Chronic venous ulcers
Clinical proteomics
Inflammatory exudate
Mass spectrometry
topic Chronic venous ulcers
Clinical proteomics
Inflammatory exudate
Mass spectrometry
description Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Twenty-three patients were female (62.2%), and five (37.8%) were male. The patients had a mean age of 70 (±10.1) years. Of the patients, 73% adhered to compression and rest, 81.1% reported a history of primary varices, 54.1% reported a history of systemic arterial hypertension, 54.1% reported a history of devitalized tissue in the wound bed and 64.9% reported ulcers with more than ten years of evolution. Seventy-six proteins were identified, and they were grouped according to their primary role in the healing process. Eight correlations between clinical and epidemiological data and protein expression were noteworthy: diabetes mellitus vs. Ig gamma-2 and apolipoprotein-A1 and albumin; congestive heart failure vs. Ig lambda-2; colonization vs. actin; compressive therapy vs. Ig kappa; systemic arterial hypertension vs. alpha-2-macroglobulin and apolipoprotein-A1; area of ulcer vs. apolipoprotein-A1; race vs. heavy chain Ig and Ig γ-1 chain; age and race vs. Ig γ-1 chain. These associations may help to elucidate the prognosis and chronicity of chronic venous ulcers based on secreted proteins.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T15:59:18Z
2019-10-06T15:59:18Z
2019-02-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jprot.2018.09.009
Journal of Proteomics, v. 192, p. 280-290.
1876-7737
1874-3919
http://hdl.handle.net/11449/188162
10.1016/j.jprot.2018.09.009
2-s2.0-85054458718
8084974543029515
url http://dx.doi.org/10.1016/j.jprot.2018.09.009
http://hdl.handle.net/11449/188162
identifier_str_mv Journal of Proteomics, v. 192, p. 280-290.
1876-7737
1874-3919
10.1016/j.jprot.2018.09.009
2-s2.0-85054458718
8084974543029515
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Proteomics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 280-290
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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