Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts

Detalhes bibliográficos
Autor(a) principal: MacOrini, Luis Fernando Benitez
Data de Publicação: 2020
Outros Autores: Radai, Joyce Alencar Santos, Maris, Rafael Souza, Silva-Filho, Saulo Euclides, Leitao, Maicon Matos, Andrade, Sérgio Faloni De, Gelves, Dayanna Isabel Araque, Salvador, Marcos Jose, Arena, Arielle Cristina [UNESP], Kassuya, Cândida Aparecida Leite
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2020/4170589
http://hdl.handle.net/11449/208034
Resumo: Gomphrena celosioides Mart. (Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus Gomphrena is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce. This study assessed the antiarthritic and antihyperalgesic activities of the ethanolic extract obtained from G. celosioides aerial parts on Swiss or C57BL/6 mice. The antiarthritic and antihyperalgesic potential of Gomphrena celosioides was evaluated using paw edema, mechanical hyperalgesia, cold allodynia, carrageenan-induced pleurisy, articular inflammation zymosan-induced, Freund's complete adjuvant-induced inflammation zymosan-induced peritonitis, and carrageenan-induced adhesion and rolling experiment models. All doses of G. celosioides (300, 700, and 1000 mg/kg) significantly reduced edema formation in all the intervals evaluated, whereas the mechanical hyperalgesia was reduced 3 hours after the carrageenan injection. The cold hyperalgesia was significantly decreased 3 (700 mg/kg) and 4 hours (700 and 1000 mg/kg) after the carrageenan injection. Ethanolic extract of G. celosioides at 1000 mg/kg reduced the total leukocyte number, without interfering in the protein extravasation in carrageenan-induced pleurisy model. Ethanolic extract of G. celosioides (300 mg/kg) was also able to reduce significantly the leukocyte migration in zymosan-induced articular edema, while a reduction of the adhesion and migration and leukocyte rolling was induced by the ethanolic extract of G. celosioides (300 mg/kg) in zymosan-induced peritonitis. In Freund's complete adjuvant-induced inflammation model, an edema formation and mechanical hyperalgesia reduction were induced by the ethanolic extract of G. celosioides on day 22, whereas the cold allodynia was reduced on day 6 of treatment with the extract. These results show that ethanolic extract of G. celosioides has antihyperalgesic and antiarthritic potential in different acute and persistent models, explaining, at least in part, the ethnopharmacological relevance of this plant as a natural analgesic agent.
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spelling Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial PartsGomphrena celosioides Mart. (Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus Gomphrena is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce. This study assessed the antiarthritic and antihyperalgesic activities of the ethanolic extract obtained from G. celosioides aerial parts on Swiss or C57BL/6 mice. The antiarthritic and antihyperalgesic potential of Gomphrena celosioides was evaluated using paw edema, mechanical hyperalgesia, cold allodynia, carrageenan-induced pleurisy, articular inflammation zymosan-induced, Freund's complete adjuvant-induced inflammation zymosan-induced peritonitis, and carrageenan-induced adhesion and rolling experiment models. All doses of G. celosioides (300, 700, and 1000 mg/kg) significantly reduced edema formation in all the intervals evaluated, whereas the mechanical hyperalgesia was reduced 3 hours after the carrageenan injection. The cold hyperalgesia was significantly decreased 3 (700 mg/kg) and 4 hours (700 and 1000 mg/kg) after the carrageenan injection. Ethanolic extract of G. celosioides at 1000 mg/kg reduced the total leukocyte number, without interfering in the protein extravasation in carrageenan-induced pleurisy model. Ethanolic extract of G. celosioides (300 mg/kg) was also able to reduce significantly the leukocyte migration in zymosan-induced articular edema, while a reduction of the adhesion and migration and leukocyte rolling was induced by the ethanolic extract of G. celosioides (300 mg/kg) in zymosan-induced peritonitis. In Freund's complete adjuvant-induced inflammation model, an edema formation and mechanical hyperalgesia reduction were induced by the ethanolic extract of G. celosioides on day 22, whereas the cold allodynia was reduced on day 6 of treatment with the extract. These results show that ethanolic extract of G. celosioides has antihyperalgesic and antiarthritic potential in different acute and persistent models, explaining, at least in part, the ethnopharmacological relevance of this plant as a natural analgesic agent.School of Health Sciences Federal University of Grande Dourados (UFGD)School of Health Sciences University Center of Grande Dourados (UNIGRAN) DouradosCollege of Pharmaceutical Sciences Food and Nutrition Federal University of Mato Grosso Do sul (UFMS)Research Center for Biosciences and Health Technologies (CBIOS) Lusofona UniversityInstitute of Biology Department of Plant Biology Ppg BTPB Ppg Bce University of Campinas (UNICAMP) Brazil Institute of BiologyDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Unesp-University Estadual Paulista-BotucatuDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Unesp-University Estadual Paulista-BotucatuFederal University of Grande Dourados (UFGD)DouradosUniversidade Federal de Mato Grosso do Sul (UFMS)Lusofona UniversityUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)MacOrini, Luis Fernando BenitezRadai, Joyce Alencar SantosMaris, Rafael SouzaSilva-Filho, Saulo EuclidesLeitao, Maicon MatosAndrade, Sérgio Faloni DeGelves, Dayanna Isabel AraqueSalvador, Marcos JoseArena, Arielle Cristina [UNESP]Kassuya, Cândida Aparecida Leite2021-06-25T11:05:12Z2021-06-25T11:05:12Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2020/4170589Evidence-based Complementary and Alternative Medicine, v. 2020.1741-42881741-427Xhttp://hdl.handle.net/11449/20803410.1155/2020/41705892-s2.0-85092350099Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicineinfo:eu-repo/semantics/openAccess2021-10-23T18:51:54Zoai:repositorio.unesp.br:11449/208034Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T18:51:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
title Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
spellingShingle Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
MacOrini, Luis Fernando Benitez
title_short Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
title_full Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
title_fullStr Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
title_full_unstemmed Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
title_sort Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts
author MacOrini, Luis Fernando Benitez
author_facet MacOrini, Luis Fernando Benitez
Radai, Joyce Alencar Santos
Maris, Rafael Souza
Silva-Filho, Saulo Euclides
Leitao, Maicon Matos
Andrade, Sérgio Faloni De
Gelves, Dayanna Isabel Araque
Salvador, Marcos Jose
Arena, Arielle Cristina [UNESP]
Kassuya, Cândida Aparecida Leite
author_role author
author2 Radai, Joyce Alencar Santos
Maris, Rafael Souza
Silva-Filho, Saulo Euclides
Leitao, Maicon Matos
Andrade, Sérgio Faloni De
Gelves, Dayanna Isabel Araque
Salvador, Marcos Jose
Arena, Arielle Cristina [UNESP]
Kassuya, Cândida Aparecida Leite
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Grande Dourados (UFGD)
Dourados
Universidade Federal de Mato Grosso do Sul (UFMS)
Lusofona University
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv MacOrini, Luis Fernando Benitez
Radai, Joyce Alencar Santos
Maris, Rafael Souza
Silva-Filho, Saulo Euclides
Leitao, Maicon Matos
Andrade, Sérgio Faloni De
Gelves, Dayanna Isabel Araque
Salvador, Marcos Jose
Arena, Arielle Cristina [UNESP]
Kassuya, Cândida Aparecida Leite
description Gomphrena celosioides Mart. (Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus Gomphrena is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce. This study assessed the antiarthritic and antihyperalgesic activities of the ethanolic extract obtained from G. celosioides aerial parts on Swiss or C57BL/6 mice. The antiarthritic and antihyperalgesic potential of Gomphrena celosioides was evaluated using paw edema, mechanical hyperalgesia, cold allodynia, carrageenan-induced pleurisy, articular inflammation zymosan-induced, Freund's complete adjuvant-induced inflammation zymosan-induced peritonitis, and carrageenan-induced adhesion and rolling experiment models. All doses of G. celosioides (300, 700, and 1000 mg/kg) significantly reduced edema formation in all the intervals evaluated, whereas the mechanical hyperalgesia was reduced 3 hours after the carrageenan injection. The cold hyperalgesia was significantly decreased 3 (700 mg/kg) and 4 hours (700 and 1000 mg/kg) after the carrageenan injection. Ethanolic extract of G. celosioides at 1000 mg/kg reduced the total leukocyte number, without interfering in the protein extravasation in carrageenan-induced pleurisy model. Ethanolic extract of G. celosioides (300 mg/kg) was also able to reduce significantly the leukocyte migration in zymosan-induced articular edema, while a reduction of the adhesion and migration and leukocyte rolling was induced by the ethanolic extract of G. celosioides (300 mg/kg) in zymosan-induced peritonitis. In Freund's complete adjuvant-induced inflammation model, an edema formation and mechanical hyperalgesia reduction were induced by the ethanolic extract of G. celosioides on day 22, whereas the cold allodynia was reduced on day 6 of treatment with the extract. These results show that ethanolic extract of G. celosioides has antihyperalgesic and antiarthritic potential in different acute and persistent models, explaining, at least in part, the ethnopharmacological relevance of this plant as a natural analgesic agent.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
2021-06-25T11:05:12Z
2021-06-25T11:05:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2020/4170589
Evidence-based Complementary and Alternative Medicine, v. 2020.
1741-4288
1741-427X
http://hdl.handle.net/11449/208034
10.1155/2020/4170589
2-s2.0-85092350099
url http://dx.doi.org/10.1155/2020/4170589
http://hdl.handle.net/11449/208034
identifier_str_mv Evidence-based Complementary and Alternative Medicine, v. 2020.
1741-4288
1741-427X
10.1155/2020/4170589
2-s2.0-85092350099
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Evidence-based Complementary and Alternative Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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