Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.brainresbull.2022.11.014 http://hdl.handle.net/11449/249004 |
Resumo: | Rationale: Several lines of evidence have demonstrated that the cannabinoid type 1 receptor (CB1) is found in the caudate nucleus and putamen (CPu) in addition to the substantia nigra pars reticulata (SNpr). Here, we investigated the role of endocannabinoid neuromodulation of striato-nigral disinhibitory projections on the activity of nigro-collicular GABAergic pathways that control the expression of unconditioned fear-related behavioural responses elicited by microinjections of the GABAA receptor selective antagonist bicuculline (BIC) in the deep layers of the superior colliculus (dlSC). Methods: Fluorescent neural tract tracers were deposited in either CPu or in SNpr. Wistar rats received injection of vehicle, anandamide (AEA), either at low (50 pmol) or high (100 pmol) concentrations in CPu followed by bicuculline microinjections in dlSC. Results: Connections between CPu, the SNpr and dlSC were demonstrated. The GABAA receptor blockade in dlSC elicited panic-like behaviour. AEA at the lowest concentration caused a panicolytic-like effect that was antagonised by the CPu pretreatment with AM251 at 100 pmol. AEA at the highest concentration caused a panicogenic-like effect that was antagonised by the CPu pretreatment with 6-iodonordihydrocapsaicin (6-I-CPS) at different concentrations (0.6, 6, 60 nmol). Conclusion: These findings suggest that while pre-synaptic CB1-signalling subserves an indirect facilitatory effect of AEA on striato-nigral pathways causing panicolytic-like responses through midbrain tectum enhanced activity, post-synaptic TRPV1-signalling in CPu mediates AEA direct activation of striato-nigral disinhibitory pathways resulting in increasing dlSC neurons activity and a panicogenic-like response. All these actions seem to depend on the interface with the nigro-collicular inhibitory GABAergic pathways. |
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Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connectionsAnandamideCaudate nucleusDeep layers of superior colliculusEndovanilloid receptorsStriatonigral-nigrotectal GABAergic pathwaysUnconditioned fearRationale: Several lines of evidence have demonstrated that the cannabinoid type 1 receptor (CB1) is found in the caudate nucleus and putamen (CPu) in addition to the substantia nigra pars reticulata (SNpr). Here, we investigated the role of endocannabinoid neuromodulation of striato-nigral disinhibitory projections on the activity of nigro-collicular GABAergic pathways that control the expression of unconditioned fear-related behavioural responses elicited by microinjections of the GABAA receptor selective antagonist bicuculline (BIC) in the deep layers of the superior colliculus (dlSC). Methods: Fluorescent neural tract tracers were deposited in either CPu or in SNpr. Wistar rats received injection of vehicle, anandamide (AEA), either at low (50 pmol) or high (100 pmol) concentrations in CPu followed by bicuculline microinjections in dlSC. Results: Connections between CPu, the SNpr and dlSC were demonstrated. The GABAA receptor blockade in dlSC elicited panic-like behaviour. AEA at the lowest concentration caused a panicolytic-like effect that was antagonised by the CPu pretreatment with AM251 at 100 pmol. AEA at the highest concentration caused a panicogenic-like effect that was antagonised by the CPu pretreatment with 6-iodonordihydrocapsaicin (6-I-CPS) at different concentrations (0.6, 6, 60 nmol). Conclusion: These findings suggest that while pre-synaptic CB1-signalling subserves an indirect facilitatory effect of AEA on striato-nigral pathways causing panicolytic-like responses through midbrain tectum enhanced activity, post-synaptic TRPV1-signalling in CPu mediates AEA direct activation of striato-nigral disinhibitory pathways resulting in increasing dlSC neurons activity and a panicogenic-like response. All these actions seem to depend on the interface with the nigro-collicular inhibitory GABAergic pathways.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)United States PharmacopeiaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP) Department of Pharmacology Laboratory of Neuroanatomy and Neuropsychobiology, São PauloSão Paulo State University (UNESP) School of Science and Literature Department of Biological Sciences, São PauloBehavioural Neuroscience Institute (INeC), São PauloNAP-USP-Neurobiology of Emotions Research Centre (NuPNE) Ribeirão Preto Medical School of the University of São Paulo, São PauloSão Paulo State University (UNESP) School of Science and Literature Department of Biological Sciences, São PauloCNPq: 130170/2009-7CNPq: 134267/2013-3CNPq: 142030/2020-1CNPq: 142844/2011-0CNPq: 145258/2015-7CNPq: 150124/2021-0CNPq: 2005.1.891.17.3FAPESP: 2007/01174-1CNPq: 2009/02458-9FAPESP: 2012/03798-0FAPESP: 2012/22681-7FAPESP: 2013/10984-8CNPq: 2015/10313-1FAPESP: 2017/11855-8FAPESP: 2018/03898-1FAPESP: 2019/01713-7FAPESP: 2019/05255-3FAPESP: 2020/15050-7CNPq: 2021/001-1CNPq: 301341/2015-0CNPq: 301905/2010-0CNPq: 302605/2021-5CNPq: 427397/2018-9CNPq: 470119/2004-7United States Pharmacopeia: IaPq2012–156-USP-12.1.25440.01.6CAPES: PNPD20131680-33002029012P3Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Behavioural Neuroscience Institute (INeC)da Silva, Juliana AlmeidaAlmada, Rafael Carvalho [UNESP]Falconi-Sobrinho, Luiz LucianoPigatto, Glauce ReginaHernandes, Paloma Molina [UNESP]Coimbra, Norberto Cysne2023-07-29T13:59:48Z2023-07-29T13:59:48Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article128-141http://dx.doi.org/10.1016/j.brainresbull.2022.11.014Brain Research Bulletin, v. 192, p. 128-141.1873-27470361-9230http://hdl.handle.net/11449/24900410.1016/j.brainresbull.2022.11.0142-s2.0-85142516793Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain Research Bulletininfo:eu-repo/semantics/openAccess2024-08-16T15:46:03Zoai:repositorio.unesp.br:11449/249004Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:46:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
title |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
spellingShingle |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections da Silva, Juliana Almeida Anandamide Caudate nucleus Deep layers of superior colliculus Endovanilloid receptors Striatonigral-nigrotectal GABAergic pathways Unconditioned fear |
title_short |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
title_full |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
title_fullStr |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
title_full_unstemmed |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
title_sort |
Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections |
author |
da Silva, Juliana Almeida |
author_facet |
da Silva, Juliana Almeida Almada, Rafael Carvalho [UNESP] Falconi-Sobrinho, Luiz Luciano Pigatto, Glauce Regina Hernandes, Paloma Molina [UNESP] Coimbra, Norberto Cysne |
author_role |
author |
author2 |
Almada, Rafael Carvalho [UNESP] Falconi-Sobrinho, Luiz Luciano Pigatto, Glauce Regina Hernandes, Paloma Molina [UNESP] Coimbra, Norberto Cysne |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Behavioural Neuroscience Institute (INeC) |
dc.contributor.author.fl_str_mv |
da Silva, Juliana Almeida Almada, Rafael Carvalho [UNESP] Falconi-Sobrinho, Luiz Luciano Pigatto, Glauce Regina Hernandes, Paloma Molina [UNESP] Coimbra, Norberto Cysne |
dc.subject.por.fl_str_mv |
Anandamide Caudate nucleus Deep layers of superior colliculus Endovanilloid receptors Striatonigral-nigrotectal GABAergic pathways Unconditioned fear |
topic |
Anandamide Caudate nucleus Deep layers of superior colliculus Endovanilloid receptors Striatonigral-nigrotectal GABAergic pathways Unconditioned fear |
description |
Rationale: Several lines of evidence have demonstrated that the cannabinoid type 1 receptor (CB1) is found in the caudate nucleus and putamen (CPu) in addition to the substantia nigra pars reticulata (SNpr). Here, we investigated the role of endocannabinoid neuromodulation of striato-nigral disinhibitory projections on the activity of nigro-collicular GABAergic pathways that control the expression of unconditioned fear-related behavioural responses elicited by microinjections of the GABAA receptor selective antagonist bicuculline (BIC) in the deep layers of the superior colliculus (dlSC). Methods: Fluorescent neural tract tracers were deposited in either CPu or in SNpr. Wistar rats received injection of vehicle, anandamide (AEA), either at low (50 pmol) or high (100 pmol) concentrations in CPu followed by bicuculline microinjections in dlSC. Results: Connections between CPu, the SNpr and dlSC were demonstrated. The GABAA receptor blockade in dlSC elicited panic-like behaviour. AEA at the lowest concentration caused a panicolytic-like effect that was antagonised by the CPu pretreatment with AM251 at 100 pmol. AEA at the highest concentration caused a panicogenic-like effect that was antagonised by the CPu pretreatment with 6-iodonordihydrocapsaicin (6-I-CPS) at different concentrations (0.6, 6, 60 nmol). Conclusion: These findings suggest that while pre-synaptic CB1-signalling subserves an indirect facilitatory effect of AEA on striato-nigral pathways causing panicolytic-like responses through midbrain tectum enhanced activity, post-synaptic TRPV1-signalling in CPu mediates AEA direct activation of striato-nigral disinhibitory pathways resulting in increasing dlSC neurons activity and a panicogenic-like response. All these actions seem to depend on the interface with the nigro-collicular inhibitory GABAergic pathways. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:59:48Z 2023-07-29T13:59:48Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.brainresbull.2022.11.014 Brain Research Bulletin, v. 192, p. 128-141. 1873-2747 0361-9230 http://hdl.handle.net/11449/249004 10.1016/j.brainresbull.2022.11.014 2-s2.0-85142516793 |
url |
http://dx.doi.org/10.1016/j.brainresbull.2022.11.014 http://hdl.handle.net/11449/249004 |
identifier_str_mv |
Brain Research Bulletin, v. 192, p. 128-141. 1873-2747 0361-9230 10.1016/j.brainresbull.2022.11.014 2-s2.0-85142516793 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain Research Bulletin |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
128-141 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128175285207040 |