Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.21577/0103-5053.20190102 http://hdl.handle.net/11449/201421 |
Resumo: | Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libraries. The aim of this work was to investigate the effects of orbitides and their linear synthetic analogues on the migration of neonatal human foreskin fibroblasts. The screening of linear peptide analogues, originally designed from natural orbitides isolated from Jatropha species, demonstrated that some molecules (linear pohlianin B and linear ribifolin) have the potential to induce fibroblast migration and collagen deposition and may thus contribute to accelerating the processes of wound healing and tissue repair. These results also demonstrate the significance of using peptides as an important tool for the discovery of simple and novel drug scaffolds. |
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Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen depositionFibroblast migrationJatrophaLinear analoguesOrbitidesOrbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libraries. The aim of this work was to investigate the effects of orbitides and their linear synthetic analogues on the migration of neonatal human foreskin fibroblasts. The screening of linear peptide analogues, originally designed from natural orbitides isolated from Jatropha species, demonstrated that some molecules (linear pohlianin B and linear ribifolin) have the potential to induce fibroblast migration and collagen deposition and may thus contribute to accelerating the processes of wound healing and tissue repair. These results also demonstrate the significance of using peptides as an important tool for the discovery of simple and novel drug scaffolds.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Instituto de Química Universidade Estadual Paulista (Unesp)Instituto de Física de São Carlos (IFSC) Universidade de São Paulo (USP)Departamento de Fisiologia e Farmacologia Universidade Federal do Ceará (UFC)Instituto de Química Universidade Estadual Paulista (Unesp)FAPESP: 2015/09533-7Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Universidade Federal do Ceará (UFC)Ramalho, Suelem D. [UNESP]Pinto, Meri Emili F. [UNESP]Andricopulo, Renata K.Sanches, Paulo R. S. [UNESP]Silveira, Edilberto R.Cilli, Eduardo M. [UNESP]Andricopulo, Adriano D.Bolzani, Vanderlan S. [UNESP]2020-12-12T02:32:05Z2020-12-12T02:32:05Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2153-2161application/pdfhttp://dx.doi.org/10.21577/0103-5053.20190102Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2153-2161, 2019.1678-47900103-5053http://hdl.handle.net/11449/20142110.21577/0103-5053.20190102S0103-505320190010021532-s2.0-85076944807S0103-50532019001002153.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Societyinfo:eu-repo/semantics/openAccess2024-01-07T06:22:28Zoai:repositorio.unesp.br:11449/201421Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:19:39.681695Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
title |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
spellingShingle |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition Ramalho, Suelem D. [UNESP] Fibroblast migration Jatropha Linear analogues Orbitides |
title_short |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
title_full |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
title_fullStr |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
title_full_unstemmed |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
title_sort |
Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition |
author |
Ramalho, Suelem D. [UNESP] |
author_facet |
Ramalho, Suelem D. [UNESP] Pinto, Meri Emili F. [UNESP] Andricopulo, Renata K. Sanches, Paulo R. S. [UNESP] Silveira, Edilberto R. Cilli, Eduardo M. [UNESP] Andricopulo, Adriano D. Bolzani, Vanderlan S. [UNESP] |
author_role |
author |
author2 |
Pinto, Meri Emili F. [UNESP] Andricopulo, Renata K. Sanches, Paulo R. S. [UNESP] Silveira, Edilberto R. Cilli, Eduardo M. [UNESP] Andricopulo, Adriano D. Bolzani, Vanderlan S. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Universidade Federal do Ceará (UFC) |
dc.contributor.author.fl_str_mv |
Ramalho, Suelem D. [UNESP] Pinto, Meri Emili F. [UNESP] Andricopulo, Renata K. Sanches, Paulo R. S. [UNESP] Silveira, Edilberto R. Cilli, Eduardo M. [UNESP] Andricopulo, Adriano D. Bolzani, Vanderlan S. [UNESP] |
dc.subject.por.fl_str_mv |
Fibroblast migration Jatropha Linear analogues Orbitides |
topic |
Fibroblast migration Jatropha Linear analogues Orbitides |
description |
Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libraries. The aim of this work was to investigate the effects of orbitides and their linear synthetic analogues on the migration of neonatal human foreskin fibroblasts. The screening of linear peptide analogues, originally designed from natural orbitides isolated from Jatropha species, demonstrated that some molecules (linear pohlianin B and linear ribifolin) have the potential to induce fibroblast migration and collagen deposition and may thus contribute to accelerating the processes of wound healing and tissue repair. These results also demonstrate the significance of using peptides as an important tool for the discovery of simple and novel drug scaffolds. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2020-12-12T02:32:05Z 2020-12-12T02:32:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0103-5053.20190102 Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2153-2161, 2019. 1678-4790 0103-5053 http://hdl.handle.net/11449/201421 10.21577/0103-5053.20190102 S0103-50532019001002153 2-s2.0-85076944807 S0103-50532019001002153.pdf |
url |
http://dx.doi.org/10.21577/0103-5053.20190102 http://hdl.handle.net/11449/201421 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2153-2161, 2019. 1678-4790 0103-5053 10.21577/0103-5053.20190102 S0103-50532019001002153 2-s2.0-85076944807 S0103-50532019001002153.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2153-2161 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129415465402368 |