Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Marcelo Eduardo [UNESP]
Data de Publicação: 2015
Outros Autores: Sequeira, Julio [UNESP], Trinca, Luzia Aparecida [UNESP], Yoshida, Winston Bonetti [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600407&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127294
Resumo: PURPOSE: Vogt´s antioxidant solution (red blood cells, Ringer's solution, sodium bicarbonate, mannitol, allopurinol and 50% glucose) or its modification including hydroxyethyl starch (HES) were tested for the prevention of splanchnic artery occlusion shock. METHODS: Seventy rats were distributed in treatment (3), control (1), and sham (3) groups. Ischemia and reperfusion were induced by celiac, superior mesenteric and inferior mesenteric arteries occlusion for 40 min, followed by 60 min reperfusion or sham procedures. Controls received saline, both treatment and sham groups received the Vogt's solution, modified Vogt's solution (replacing Ringer's solution by HES), or HES. Mean arterial blood pressure (MABP), ileal malondialdehyde (MDA) and plasmatic MDA were determined, and a histologic grading system was used. RESULTS: At reperfusion, MABP dropped in all I/R groups. Only HES treatment was able to restore final MABP to the levels of sham groups. Plasmatic MDA did not show differences between groups. Ileum MDA was significantly higher in the control and treatment groups as compared to the sham group. Histology ranking was higher in the only in control group. CONCLUSIONS: Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. Both treatments with Vogt's solutions did not show any improvement.
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spelling Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organsIschemiaReperfusionProtective agentsHydroxyethyl Starch DerivativesFree radicalsAntioxidantsRatsPURPOSE: Vogt´s antioxidant solution (red blood cells, Ringer's solution, sodium bicarbonate, mannitol, allopurinol and 50% glucose) or its modification including hydroxyethyl starch (HES) were tested for the prevention of splanchnic artery occlusion shock. METHODS: Seventy rats were distributed in treatment (3), control (1), and sham (3) groups. Ischemia and reperfusion were induced by celiac, superior mesenteric and inferior mesenteric arteries occlusion for 40 min, followed by 60 min reperfusion or sham procedures. Controls received saline, both treatment and sham groups received the Vogt's solution, modified Vogt's solution (replacing Ringer's solution by HES), or HES. Mean arterial blood pressure (MABP), ileal malondialdehyde (MDA) and plasmatic MDA were determined, and a histologic grading system was used. RESULTS: At reperfusion, MABP dropped in all I/R groups. Only HES treatment was able to restore final MABP to the levels of sham groups. Plasmatic MDA did not show differences between groups. Ileum MDA was significantly higher in the control and treatment groups as compared to the sham group. Histology ranking was higher in the only in control group. CONCLUSIONS: Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. Both treatments with Vogt's solutions did not show any improvement.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Paulista State University Botucatu School of Medicine Department of Surgery and OrthopedicsUNESP School of Medicine Department of Pathology, Veterinary Medicine and ZootechnicsUNESP Biosciences Institute Department of StatisticsUNESP Department of Surgery and OrthopedicsPaulista State University Botucatu School of Medicine Department of Surgery and OrthopedicsUNESP School of Medicine Department of Pathology, Veterinary Medicine and ZootechnicsUNESP Biosciences Institute Department of StatisticsUNESP Department of Surgery and OrthopedicsFAPESP: 1997/04647-4Sociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual Paulista (Unesp)Ribeiro, Marcelo Eduardo [UNESP]Sequeira, Julio [UNESP]Trinca, Luzia Aparecida [UNESP]Yoshida, Winston Bonetti [UNESP]2015-08-26T19:19:03Z2015-08-26T19:19:03Z2015-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article407-413application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600407&lng=en&nrm=iso&tlng=enActa Cirurgica Brasileira, v. 30, n. 6, p. 407-413, 2015.0102-8650http://hdl.handle.net/11449/12729410.1590/S0102-865020150060000006S0102-86502015000600407S0102-86502015000600407.pdf36138352316549323720489366427955SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0.9330,395info:eu-repo/semantics/openAccess2024-09-03T13:15:27Zoai:repositorio.unesp.br:11449/127294Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
title Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
spellingShingle Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
Ribeiro, Marcelo Eduardo [UNESP]
Ischemia
Reperfusion
Protective agents
Hydroxyethyl Starch Derivatives
Free radicals
Antioxidants
Rats
title_short Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
title_full Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
title_fullStr Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
title_full_unstemmed Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
title_sort Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
author Ribeiro, Marcelo Eduardo [UNESP]
author_facet Ribeiro, Marcelo Eduardo [UNESP]
Sequeira, Julio [UNESP]
Trinca, Luzia Aparecida [UNESP]
Yoshida, Winston Bonetti [UNESP]
author_role author
author2 Sequeira, Julio [UNESP]
Trinca, Luzia Aparecida [UNESP]
Yoshida, Winston Bonetti [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ribeiro, Marcelo Eduardo [UNESP]
Sequeira, Julio [UNESP]
Trinca, Luzia Aparecida [UNESP]
Yoshida, Winston Bonetti [UNESP]
dc.subject.por.fl_str_mv Ischemia
Reperfusion
Protective agents
Hydroxyethyl Starch Derivatives
Free radicals
Antioxidants
Rats
topic Ischemia
Reperfusion
Protective agents
Hydroxyethyl Starch Derivatives
Free radicals
Antioxidants
Rats
description PURPOSE: Vogt´s antioxidant solution (red blood cells, Ringer's solution, sodium bicarbonate, mannitol, allopurinol and 50% glucose) or its modification including hydroxyethyl starch (HES) were tested for the prevention of splanchnic artery occlusion shock. METHODS: Seventy rats were distributed in treatment (3), control (1), and sham (3) groups. Ischemia and reperfusion were induced by celiac, superior mesenteric and inferior mesenteric arteries occlusion for 40 min, followed by 60 min reperfusion or sham procedures. Controls received saline, both treatment and sham groups received the Vogt's solution, modified Vogt's solution (replacing Ringer's solution by HES), or HES. Mean arterial blood pressure (MABP), ileal malondialdehyde (MDA) and plasmatic MDA were determined, and a histologic grading system was used. RESULTS: At reperfusion, MABP dropped in all I/R groups. Only HES treatment was able to restore final MABP to the levels of sham groups. Plasmatic MDA did not show differences between groups. Ileum MDA was significantly higher in the control and treatment groups as compared to the sham group. Histology ranking was higher in the only in control group. CONCLUSIONS: Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. Both treatments with Vogt's solutions did not show any improvement.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-26T19:19:03Z
2015-08-26T19:19:03Z
2015-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600407&lng=en&nrm=iso&tlng=en
Acta Cirurgica Brasileira, v. 30, n. 6, p. 407-413, 2015.
0102-8650
http://hdl.handle.net/11449/127294
10.1590/S0102-865020150060000006
S0102-86502015000600407
S0102-86502015000600407.pdf
3613835231654932
3720489366427955
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600407&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127294
identifier_str_mv Acta Cirurgica Brasileira, v. 30, n. 6, p. 407-413, 2015.
0102-8650
10.1590/S0102-865020150060000006
S0102-86502015000600407
S0102-86502015000600407.pdf
3613835231654932
3720489366427955
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
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0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 407-413
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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