Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Pagan, Luana Urbano [UNESP]
Data de Publicação: 2015
Outros Autores: Damatto, Ricardo Luiz [UNESP], Cezar, Marcelo Diarcadia Mariano [UNESP], Lima, Aline Regina Ruiz [UNESP], Bonomo, Camila [UNESP], Campos, Dijon Henrique Salomé de [UNESP], Gomes, Mariana Janini [UNESP], Martinez, Paula Felippe, Oliveira Junior, Silvio Assis de, Gimenes, Rodrigo [UNESP], Rosa, Camila Moreno [UNESP], Guizoni, Daniele Mendes [UNESP], Moukbel, Yasmin Ciamaricone [UNESP], Cicogna, Antonio Carlos [UNESP], Okoshi, Marina Politi [UNESP], Okoshi, Katashi [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.karger.com/Article/FullText/374053
http://hdl.handle.net/11449/128298
Resumo: Background: Physical exercise is a strategy to control hypertension and attenuate pressure overload-induced cardiac remodeling. The influence of exercise on cardiac remodeling during uncontrolled hypertension is not established. We evaluated the effects of a long-term low intensity aerobic exercise protocol on heart failure (HF) development and cardiac remodeling in aging spontaneously hypertensive rats (SHR). Methods: Sixteen month old SHR (n=50) and normotensive Wistar-Kyoto (WKY, n=35) rats were divided into sedentary (SED) and exercised (EX) groups. Rats exercised in treadmill at 12 m/min, 30 min/day, 5 days/week, for four months. The frequency of HF features was evaluated at euthanasia. Statistical analyses: ANOVA and Tukey or Mann-Whitney, and Goodman test. Results: Despite slightly higher systolic blood pressure, SHR-EX had better functional capacity and lower HF frequency than SHR-SED. Echocardiography and tissue Doppler imaging showed no differences between SHR groups. In SHR-EX, however, left ventricular (LV) systolic diameter, larger in SHR-SED than WKY-SED, and endocardial fractional shortening, lower in SHR-SED than WKY-SED, had values between those in WKY-EX and SHR-SED not differing from either group. Myocardial function, assessed in LV papillary muscles, showed improvement in SHR-EX over SHR-SED and WKY-EX. LV myocardial collagen fraction and type I and III collagen gene expression were increased in SHR groups. Myocardial hydroxyproline concentration was lower in SHR-EX than SHR-SED. Lysyl oxidase gene expression was higher in SHR-SED than WKY-SED. Conclusion: Exercise improves functional capacity and reduces decompensated HF in aging SHR independent of elevated arterial pressure. Improvement in functional status is combined with attenuation of LV and myocardial dysfunction and fibrosis.
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spelling Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive ratsSpontaneously hypertensive ratTissue Doppler imagingEchocardiographyPapillary muscleMyocardial fibrosisBackground: Physical exercise is a strategy to control hypertension and attenuate pressure overload-induced cardiac remodeling. The influence of exercise on cardiac remodeling during uncontrolled hypertension is not established. We evaluated the effects of a long-term low intensity aerobic exercise protocol on heart failure (HF) development and cardiac remodeling in aging spontaneously hypertensive rats (SHR). Methods: Sixteen month old SHR (n=50) and normotensive Wistar-Kyoto (WKY, n=35) rats were divided into sedentary (SED) and exercised (EX) groups. Rats exercised in treadmill at 12 m/min, 30 min/day, 5 days/week, for four months. The frequency of HF features was evaluated at euthanasia. Statistical analyses: ANOVA and Tukey or Mann-Whitney, and Goodman test. Results: Despite slightly higher systolic blood pressure, SHR-EX had better functional capacity and lower HF frequency than SHR-SED. Echocardiography and tissue Doppler imaging showed no differences between SHR groups. In SHR-EX, however, left ventricular (LV) systolic diameter, larger in SHR-SED than WKY-SED, and endocardial fractional shortening, lower in SHR-SED than WKY-SED, had values between those in WKY-EX and SHR-SED not differing from either group. Myocardial function, assessed in LV papillary muscles, showed improvement in SHR-EX over SHR-SED and WKY-EX. LV myocardial collagen fraction and type I and III collagen gene expression were increased in SHR groups. Myocardial hydroxyproline concentration was lower in SHR-EX than SHR-SED. Lysyl oxidase gene expression was higher in SHR-SED than WKY-SED. Conclusion: Exercise improves functional capacity and reduces decompensated HF in aging SHR independent of elevated arterial pressure. Improvement in functional status is combined with attenuation of LV and myocardial dysfunction and fibrosis.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de BotucatuCNPq: 306857/2012-0CNPq: 306845/2012-1CNPq: 480829/2013-6FAPESP: 2009/54506-7KargerUniversidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso do Sul (UFMS)Pagan, Luana Urbano [UNESP]Damatto, Ricardo Luiz [UNESP]Cezar, Marcelo Diarcadia Mariano [UNESP]Lima, Aline Regina Ruiz [UNESP]Bonomo, Camila [UNESP]Campos, Dijon Henrique Salomé de [UNESP]Gomes, Mariana Janini [UNESP]Martinez, Paula FelippeOliveira Junior, Silvio Assis deGimenes, Rodrigo [UNESP]Rosa, Camila Moreno [UNESP]Guizoni, Daniele Mendes [UNESP]Moukbel, Yasmin Ciamaricone [UNESP]Cicogna, Antonio Carlos [UNESP]Okoshi, Marina Politi [UNESP]Okoshi, Katashi [UNESP]2015-10-21T13:08:48Z2015-10-21T13:08:48Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article61-74application/pdfhttp://www.karger.com/Article/FullText/374053Cellular Physiology And Biochemistry. Basel: Karger, v. 36, n. 1, p. 61-74, 2015.1015-8987http://hdl.handle.net/11449/12829810.1159/000374053WOS:000355017300005WOS000355017300005.pdf941897010356413744631386719984321590971576309420Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCellular Physiology And Biochemistry5.5001,561info:eu-repo/semantics/openAccess2024-08-14T17:23:21Zoai:repositorio.unesp.br:11449/128298Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
title Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
spellingShingle Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
Pagan, Luana Urbano [UNESP]
Spontaneously hypertensive rat
Tissue Doppler imaging
Echocardiography
Papillary muscle
Myocardial fibrosis
title_short Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
title_full Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
title_fullStr Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
title_full_unstemmed Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
title_sort Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats
author Pagan, Luana Urbano [UNESP]
author_facet Pagan, Luana Urbano [UNESP]
Damatto, Ricardo Luiz [UNESP]
Cezar, Marcelo Diarcadia Mariano [UNESP]
Lima, Aline Regina Ruiz [UNESP]
Bonomo, Camila [UNESP]
Campos, Dijon Henrique Salomé de [UNESP]
Gomes, Mariana Janini [UNESP]
Martinez, Paula Felippe
Oliveira Junior, Silvio Assis de
Gimenes, Rodrigo [UNESP]
Rosa, Camila Moreno [UNESP]
Guizoni, Daniele Mendes [UNESP]
Moukbel, Yasmin Ciamaricone [UNESP]
Cicogna, Antonio Carlos [UNESP]
Okoshi, Marina Politi [UNESP]
Okoshi, Katashi [UNESP]
author_role author
author2 Damatto, Ricardo Luiz [UNESP]
Cezar, Marcelo Diarcadia Mariano [UNESP]
Lima, Aline Regina Ruiz [UNESP]
Bonomo, Camila [UNESP]
Campos, Dijon Henrique Salomé de [UNESP]
Gomes, Mariana Janini [UNESP]
Martinez, Paula Felippe
Oliveira Junior, Silvio Assis de
Gimenes, Rodrigo [UNESP]
Rosa, Camila Moreno [UNESP]
Guizoni, Daniele Mendes [UNESP]
Moukbel, Yasmin Ciamaricone [UNESP]
Cicogna, Antonio Carlos [UNESP]
Okoshi, Marina Politi [UNESP]
Okoshi, Katashi [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.author.fl_str_mv Pagan, Luana Urbano [UNESP]
Damatto, Ricardo Luiz [UNESP]
Cezar, Marcelo Diarcadia Mariano [UNESP]
Lima, Aline Regina Ruiz [UNESP]
Bonomo, Camila [UNESP]
Campos, Dijon Henrique Salomé de [UNESP]
Gomes, Mariana Janini [UNESP]
Martinez, Paula Felippe
Oliveira Junior, Silvio Assis de
Gimenes, Rodrigo [UNESP]
Rosa, Camila Moreno [UNESP]
Guizoni, Daniele Mendes [UNESP]
Moukbel, Yasmin Ciamaricone [UNESP]
Cicogna, Antonio Carlos [UNESP]
Okoshi, Marina Politi [UNESP]
Okoshi, Katashi [UNESP]
dc.subject.por.fl_str_mv Spontaneously hypertensive rat
Tissue Doppler imaging
Echocardiography
Papillary muscle
Myocardial fibrosis
topic Spontaneously hypertensive rat
Tissue Doppler imaging
Echocardiography
Papillary muscle
Myocardial fibrosis
description Background: Physical exercise is a strategy to control hypertension and attenuate pressure overload-induced cardiac remodeling. The influence of exercise on cardiac remodeling during uncontrolled hypertension is not established. We evaluated the effects of a long-term low intensity aerobic exercise protocol on heart failure (HF) development and cardiac remodeling in aging spontaneously hypertensive rats (SHR). Methods: Sixteen month old SHR (n=50) and normotensive Wistar-Kyoto (WKY, n=35) rats were divided into sedentary (SED) and exercised (EX) groups. Rats exercised in treadmill at 12 m/min, 30 min/day, 5 days/week, for four months. The frequency of HF features was evaluated at euthanasia. Statistical analyses: ANOVA and Tukey or Mann-Whitney, and Goodman test. Results: Despite slightly higher systolic blood pressure, SHR-EX had better functional capacity and lower HF frequency than SHR-SED. Echocardiography and tissue Doppler imaging showed no differences between SHR groups. In SHR-EX, however, left ventricular (LV) systolic diameter, larger in SHR-SED than WKY-SED, and endocardial fractional shortening, lower in SHR-SED than WKY-SED, had values between those in WKY-EX and SHR-SED not differing from either group. Myocardial function, assessed in LV papillary muscles, showed improvement in SHR-EX over SHR-SED and WKY-EX. LV myocardial collagen fraction and type I and III collagen gene expression were increased in SHR groups. Myocardial hydroxyproline concentration was lower in SHR-EX than SHR-SED. Lysyl oxidase gene expression was higher in SHR-SED than WKY-SED. Conclusion: Exercise improves functional capacity and reduces decompensated HF in aging SHR independent of elevated arterial pressure. Improvement in functional status is combined with attenuation of LV and myocardial dysfunction and fibrosis.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:08:48Z
2015-10-21T13:08:48Z
2015-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.karger.com/Article/FullText/374053
Cellular Physiology And Biochemistry. Basel: Karger, v. 36, n. 1, p. 61-74, 2015.
1015-8987
http://hdl.handle.net/11449/128298
10.1159/000374053
WOS:000355017300005
WOS000355017300005.pdf
9418970103564137
4463138671998432
1590971576309420
url http://www.karger.com/Article/FullText/374053
http://hdl.handle.net/11449/128298
identifier_str_mv Cellular Physiology And Biochemistry. Basel: Karger, v. 36, n. 1, p. 61-74, 2015.
1015-8987
10.1159/000374053
WOS:000355017300005
WOS000355017300005.pdf
9418970103564137
4463138671998432
1590971576309420
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cellular Physiology And Biochemistry
5.500
1,561
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 61-74
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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