High plasma uric acid concentration: causes and consequences
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1758-5996-4-12 http://hdl.handle.net/11449/12886 |
Resumo: | High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease. |
id |
UNSP_67742c750085ee1ba49d42eb2b385675 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/12886 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
High plasma uric acid concentration: causes and consequencesUric acidDietProtectionRiskMetabolic syndromeHigh plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Botucatu Sch Med UNESP, Dept Publ Hlth, Ctr Exercise Metab & Nutr CeMENutri, Botucatu, SP, BrazilBotucatu Sch Med UNESP, Dept Pathol, Botucatu, SP, BrazilDept Saúde Publ FMBUNESP, CeMENutri Fac Med, BR-18618970 Botucatu, SP, BrazilBotucatu Sch Med UNESP, Dept Publ Hlth, Ctr Exercise Metab & Nutr CeMENutri, Botucatu, SP, BrazilBotucatu Sch Med UNESP, Dept Pathol, Botucatu, SP, BrazilDept Saúde Publ FMBUNESP, CeMENutri Fac Med, BR-18618970 Botucatu, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)de Oliveira, Erick Prado [UNESP]Burini, Roberto Carlos [UNESP]2014-05-20T13:37:17Z2014-05-20T13:37:17Z2012-04-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1758-5996-4-12Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.1758-5996http://hdl.handle.net/11449/1288610.1186/1758-5996-4-12WOS:000304677700001WOS000304677700001.pdf2287552780901172Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiabetology & Metabolic Syndrome2.4130,943info:eu-repo/semantics/openAccess2024-09-03T14:11:31Zoai:repositorio.unesp.br:11449/12886Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:11:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
High plasma uric acid concentration: causes and consequences |
title |
High plasma uric acid concentration: causes and consequences |
spellingShingle |
High plasma uric acid concentration: causes and consequences de Oliveira, Erick Prado [UNESP] Uric acid Diet Protection Risk Metabolic syndrome |
title_short |
High plasma uric acid concentration: causes and consequences |
title_full |
High plasma uric acid concentration: causes and consequences |
title_fullStr |
High plasma uric acid concentration: causes and consequences |
title_full_unstemmed |
High plasma uric acid concentration: causes and consequences |
title_sort |
High plasma uric acid concentration: causes and consequences |
author |
de Oliveira, Erick Prado [UNESP] |
author_facet |
de Oliveira, Erick Prado [UNESP] Burini, Roberto Carlos [UNESP] |
author_role |
author |
author2 |
Burini, Roberto Carlos [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Oliveira, Erick Prado [UNESP] Burini, Roberto Carlos [UNESP] |
dc.subject.por.fl_str_mv |
Uric acid Diet Protection Risk Metabolic syndrome |
topic |
Uric acid Diet Protection Risk Metabolic syndrome |
description |
High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-04 2014-05-20T13:37:17Z 2014-05-20T13:37:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1758-5996-4-12 Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012. 1758-5996 http://hdl.handle.net/11449/12886 10.1186/1758-5996-4-12 WOS:000304677700001 WOS000304677700001.pdf 2287552780901172 |
url |
http://dx.doi.org/10.1186/1758-5996-4-12 http://hdl.handle.net/11449/12886 |
identifier_str_mv |
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012. 1758-5996 10.1186/1758-5996-4-12 WOS:000304677700001 WOS000304677700001.pdf 2287552780901172 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Diabetology & Metabolic Syndrome 2.413 0,943 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021373691559936 |