Experimental maxillary sinus augmentation using a highly bioactive glass ceramic
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10856-015-5652-7 http://hdl.handle.net/11449/172357 |
Resumo: | Physicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO—particulate bovine HA Bio-Oss® (BO), BO+G—particulate bovine HA + particulate autogenous bone graft (G), BS—particulate glass ceramic (180–212 μm) Biosilicate® (BS), and BS+G—particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (μCT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and μCT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate® are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation. |
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Experimental maxillary sinus augmentation using a highly bioactive glass ceramicPhysicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO—particulate bovine HA Bio-Oss® (BO), BO+G—particulate bovine HA + particulate autogenous bone graft (G), BS—particulate glass ceramic (180–212 μm) Biosilicate® (BS), and BS+G—particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (μCT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and μCT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate® are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75Oral Biology Master’s Program Sagrado Coração University – USC, Rua Irmã Arminda 10-50Oral Biology Doctoral’s Program Bauru School of Dentistry University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75Department of Bioscience Federal University of Sao Paulo, Campus Baixada Santista – UNIFESP, Avenida Ana Costa, 95Department of Basic Sciences Araçatuba School of Dentistry São Paulo State University FOA/UNESP, Rua José Bonifácio 1193Oral Biology Doctoral’s Program Sagrado Coração University USCCNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)Department of Basic Sciences Araçatuba School of Dentistry São Paulo State University FOA/UNESP, Rua José Bonifácio 1193FAPESP: 2008/11485-8; 2009Universidade de São Paulo (USP)Sagrado Coração University – USCUniversidade Estadual Paulista (Unesp)USCCNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)Vivan, Rodrigo RicciMecca, Carlos EduardoBiguetti, Claudia CristinaRennó, Ana Claudia MunizOkamoto, Roberta [UNESP]Cavenago, Bruno CavaliniDuarte, Marco HúngaroMatsumoto, Mariza Akemi [UNESP]2018-12-11T16:59:53Z2018-12-11T16:59:53Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-10application/pdfhttp://dx.doi.org/10.1007/s10856-015-5652-7Journal of Materials Science: Materials in Medicine, v. 27, n. 2, p. 1-10, 2016.1573-48380957-4530http://hdl.handle.net/11449/17235710.1007/s10856-015-5652-72-s2.0-849518718302-s2.0-84951871830.pdf8621510886887389Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Materials Science: Materials in Medicine0,6470,647info:eu-repo/semantics/openAccess2024-01-03T06:19:07Zoai:repositorio.unesp.br:11449/172357Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:58:43.054867Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
title |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
spellingShingle |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic Vivan, Rodrigo Ricci |
title_short |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
title_full |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
title_fullStr |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
title_full_unstemmed |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
title_sort |
Experimental maxillary sinus augmentation using a highly bioactive glass ceramic |
author |
Vivan, Rodrigo Ricci |
author_facet |
Vivan, Rodrigo Ricci Mecca, Carlos Eduardo Biguetti, Claudia Cristina Rennó, Ana Claudia Muniz Okamoto, Roberta [UNESP] Cavenago, Bruno Cavalini Duarte, Marco Húngaro Matsumoto, Mariza Akemi [UNESP] |
author_role |
author |
author2 |
Mecca, Carlos Eduardo Biguetti, Claudia Cristina Rennó, Ana Claudia Muniz Okamoto, Roberta [UNESP] Cavenago, Bruno Cavalini Duarte, Marco Húngaro Matsumoto, Mariza Akemi [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Sagrado Coração University – USC Universidade Estadual Paulista (Unesp) USC CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) |
dc.contributor.author.fl_str_mv |
Vivan, Rodrigo Ricci Mecca, Carlos Eduardo Biguetti, Claudia Cristina Rennó, Ana Claudia Muniz Okamoto, Roberta [UNESP] Cavenago, Bruno Cavalini Duarte, Marco Húngaro Matsumoto, Mariza Akemi [UNESP] |
description |
Physicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO—particulate bovine HA Bio-Oss® (BO), BO+G—particulate bovine HA + particulate autogenous bone graft (G), BS—particulate glass ceramic (180–212 μm) Biosilicate® (BS), and BS+G—particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (μCT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and μCT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate® are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 2018-12-11T16:59:53Z 2018-12-11T16:59:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10856-015-5652-7 Journal of Materials Science: Materials in Medicine, v. 27, n. 2, p. 1-10, 2016. 1573-4838 0957-4530 http://hdl.handle.net/11449/172357 10.1007/s10856-015-5652-7 2-s2.0-84951871830 2-s2.0-84951871830.pdf 8621510886887389 |
url |
http://dx.doi.org/10.1007/s10856-015-5652-7 http://hdl.handle.net/11449/172357 |
identifier_str_mv |
Journal of Materials Science: Materials in Medicine, v. 27, n. 2, p. 1-10, 2016. 1573-4838 0957-4530 10.1007/s10856-015-5652-7 2-s2.0-84951871830 2-s2.0-84951871830.pdf 8621510886887389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Materials Science: Materials in Medicine 0,647 0,647 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-10 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129380332863488 |