Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1242/jeb.219501 http://hdl.handle.net/11449/198839 |
Resumo: | This study evaluated the effect of exposure to either a chronic variable stress (CVS) protocol or social isolation, as well as treadmill exercise training, in the habituation of the cardiovascular response upon repeated exposure to restraint stress in rats. The habituation of the corticosterone response to repeated restraint stress was also evaluated. For this, animals were subjected to either acute or 10 daily sessions of 60 min of restraint stress. CVS and social isolation protocols lasted for 10 consecutive days, whereas treadmill training was performed for 1 h per day, 5 days per week for 8 weeks. We observed that the increase in serum corticosterone was reduced during both the stress and the recovery period of the 10th session of restraint. Habituation of the cardiovascular response was identified in terms of a faster return of heart rate to baseline values during the recovery period of the 10th session of restraint. The increase in blood pressure and the decrease in tail skin temperature were similar at the 1st and 10th session of restraint. Exposure to CVS, social isolation or treadmill exercise training inhibited the habituation of the restraint-evoked tachycardia. Additionally, CVS increased the blood pressure response at the 10th session of restraint, whereas social isolation enhanced both the tachycardia during the first session and the drop in skin temperature at the 10th session of restraint. Taken together, these findings provide new evidence that pathologies evoked by stress might be related to impairment in the habituation process to homotypic stressors. |
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Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise trainingAdaptationBlood pressureChronic variable stressCorticosteroneHeart rateSocial isolationThis study evaluated the effect of exposure to either a chronic variable stress (CVS) protocol or social isolation, as well as treadmill exercise training, in the habituation of the cardiovascular response upon repeated exposure to restraint stress in rats. The habituation of the corticosterone response to repeated restraint stress was also evaluated. For this, animals were subjected to either acute or 10 daily sessions of 60 min of restraint stress. CVS and social isolation protocols lasted for 10 consecutive days, whereas treadmill training was performed for 1 h per day, 5 days per week for 8 weeks. We observed that the increase in serum corticosterone was reduced during both the stress and the recovery period of the 10th session of restraint. Habituation of the cardiovascular response was identified in terms of a faster return of heart rate to baseline values during the recovery period of the 10th session of restraint. The increase in blood pressure and the decrease in tail skin temperature were similar at the 1st and 10th session of restraint. Exposure to CVS, social isolation or treadmill exercise training inhibited the habituation of the restraint-evoked tachycardia. Additionally, CVS increased the blood pressure response at the 10th session of restraint, whereas social isolation enhanced both the tachycardia during the first session and the drop in skin temperature at the 10th session of restraint. Taken together, these findings provide new evidence that pathologies evoked by stress might be related to impairment in the habituation process to homotypic stressors.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Laboratory of Pharmacology Saõ Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCarUNESP Graduate Program in Physiological SciencesDepartment of Adapted Physical Activity Faculty of Physical Education University of Campinas - UNICAMPLaboratory of Pharmacology Saõ Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCarUNESP Graduate Program in Physiological SciencesFAPESP: 2015/05922-9FAPESP: 2017/19249-0CNPq: 456405/2014-3Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Benini, Ricardo [UNESP]Oliveira, Leandro A. [UNESP]Gomes-De-Souza, Lucas [UNESP]Rodrigues, BrunoCrestani, Carlos C. [UNESP]2020-12-12T01:23:24Z2020-12-12T01:23:24Z2020-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1242/jeb.219501Journal of Experimental Biology, v. 223, n. 8, 2020.1477-91450022-0949http://hdl.handle.net/11449/19883910.1242/jeb.2195012-s2.0-85084760837Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Experimental Biologyinfo:eu-repo/semantics/openAccess2021-10-22T20:36:31Zoai:repositorio.unesp.br:11449/198839Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:35:23.990078Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
title |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
spellingShingle |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training Benini, Ricardo [UNESP] Adaptation Blood pressure Chronic variable stress Corticosterone Heart rate Social isolation |
title_short |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
title_full |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
title_fullStr |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
title_full_unstemmed |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
title_sort |
Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training |
author |
Benini, Ricardo [UNESP] |
author_facet |
Benini, Ricardo [UNESP] Oliveira, Leandro A. [UNESP] Gomes-De-Souza, Lucas [UNESP] Rodrigues, Bruno Crestani, Carlos C. [UNESP] |
author_role |
author |
author2 |
Oliveira, Leandro A. [UNESP] Gomes-De-Souza, Lucas [UNESP] Rodrigues, Bruno Crestani, Carlos C. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Benini, Ricardo [UNESP] Oliveira, Leandro A. [UNESP] Gomes-De-Souza, Lucas [UNESP] Rodrigues, Bruno Crestani, Carlos C. [UNESP] |
dc.subject.por.fl_str_mv |
Adaptation Blood pressure Chronic variable stress Corticosterone Heart rate Social isolation |
topic |
Adaptation Blood pressure Chronic variable stress Corticosterone Heart rate Social isolation |
description |
This study evaluated the effect of exposure to either a chronic variable stress (CVS) protocol or social isolation, as well as treadmill exercise training, in the habituation of the cardiovascular response upon repeated exposure to restraint stress in rats. The habituation of the corticosterone response to repeated restraint stress was also evaluated. For this, animals were subjected to either acute or 10 daily sessions of 60 min of restraint stress. CVS and social isolation protocols lasted for 10 consecutive days, whereas treadmill training was performed for 1 h per day, 5 days per week for 8 weeks. We observed that the increase in serum corticosterone was reduced during both the stress and the recovery period of the 10th session of restraint. Habituation of the cardiovascular response was identified in terms of a faster return of heart rate to baseline values during the recovery period of the 10th session of restraint. The increase in blood pressure and the decrease in tail skin temperature were similar at the 1st and 10th session of restraint. Exposure to CVS, social isolation or treadmill exercise training inhibited the habituation of the restraint-evoked tachycardia. Additionally, CVS increased the blood pressure response at the 10th session of restraint, whereas social isolation enhanced both the tachycardia during the first session and the drop in skin temperature at the 10th session of restraint. Taken together, these findings provide new evidence that pathologies evoked by stress might be related to impairment in the habituation process to homotypic stressors. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:23:24Z 2020-12-12T01:23:24Z 2020-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1242/jeb.219501 Journal of Experimental Biology, v. 223, n. 8, 2020. 1477-9145 0022-0949 http://hdl.handle.net/11449/198839 10.1242/jeb.219501 2-s2.0-85084760837 |
url |
http://dx.doi.org/10.1242/jeb.219501 http://hdl.handle.net/11449/198839 |
identifier_str_mv |
Journal of Experimental Biology, v. 223, n. 8, 2020. 1477-9145 0022-0949 10.1242/jeb.219501 2-s2.0-85084760837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Experimental Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128538278100992 |