Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices

Detalhes bibliográficos
Autor(a) principal: Afonso, Juliana
Data de Publicação: 2019
Outros Autores: Coutinho, Luiz Lehmann, Tizioto, Polyana Cristine, Silva Diniz, Wellison Jarles da, Lima, Andressa Oliveira de, Pereira Rocha, Marina Ibelli, Buss, Carlos Eduardo, Nascimento Andrade, Bruno Gabriel, Piaya, Otavio, Silva, Juliana Virginio da, Lins, Laura Albuquerque [UNESP], Gromboni, Caio Fernando, Araujo Nogueira, Ana Rita, Salinas Fortes, Marina Rufino, Mourao, Gerson Barreto, Almeida Regitano, Luciana Correia de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1038/s41598-019-49089-x
http://hdl.handle.net/11449/184684
Resumo: Mineral content affects the biological processes underlying beef quality. Muscle mineral concentration depends not only on intake-outtake balance and muscle type, but also on age, environment, breed, and genetic factors. To unveil the genetic factors involved in muscle mineral concentration, we applied a pairwise differential gene expression analysis in groups of Nelore steers genetically divergent for nine different mineral concentrations. Here, based on significant expression differences between contrasting groups, we presented candidate genes for the genetic regulation of mineral concentration in muscle. Functional enrichment and protein-protein interaction network analyses were carried out to search for gene regulatory processes concerning each mineral. The core genetic regulation for all minerals studied, except Zn, seems to rest on interactions between components of the extracellular matrix. Regulation of adipogenesis-related pathways was also significant in our results. Antagonistic patterns of gene expression for fatty acid metabolism-related genes may explain the Cu and Zn antagonistic effect on fatty acid accumulation. Our results shed light on the role of these minerals on cell function.
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spelling Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicesMineral content affects the biological processes underlying beef quality. Muscle mineral concentration depends not only on intake-outtake balance and muscle type, but also on age, environment, breed, and genetic factors. To unveil the genetic factors involved in muscle mineral concentration, we applied a pairwise differential gene expression analysis in groups of Nelore steers genetically divergent for nine different mineral concentrations. Here, based on significant expression differences between contrasting groups, we presented candidate genes for the genetic regulation of mineral concentration in muscle. Functional enrichment and protein-protein interaction network analyses were carried out to search for gene regulatory processes concerning each mineral. The core genetic regulation for all minerals studied, except Zn, seems to rest on interactions between components of the extracellular matrix. Regulation of adipogenesis-related pathways was also significant in our results. Antagonistic patterns of gene expression for fatty acid metabolism-related genes may explain the Cu and Zn antagonistic effect on fatty acid accumulation. Our results shed light on the role of these minerals on cell function.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Sao Carlos, Dept Evolutionary Genet & Mol Biol, Sao Carlos, SP, BrazilUniv Sao Paulo, Dept Anim Sci, ESALQ, Piracicaba, BrazilEmbrapa Pecuaria Sudeste, Sao Carlos, SP, BrazilUniv Sao Paulo, Phys Inst Sao Carlos, Sao Carlos, SP, BrazilSao Paulo State Univ, Anim Sci Dept, Lab Mol Genet, Jaboticabal, BrazilBahia Fed Inst Educ Sci & Technol, Ilheus, BrazilUniv Queensland, Fac Sci, Sch Chem & Mol Biosci, Brisbane, Qld, AustraliaNGS Solucoes Genom, Rua Ajudante Albano 847, Piracicaba, SP, BrazilSao Paulo State Univ, Anim Sci Dept, Lab Mol Genet, Jaboticabal, BrazilFAPESP: 2012/23638-8Nature Publishing GroupUniversidade Federal de São Carlos (UFSCar)Universidade de São Paulo (USP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Estadual Paulista (Unesp)Bahia Fed Inst Educ Sci & TechnolUniv QueenslandNGS Solucoes GenomAfonso, JulianaCoutinho, Luiz LehmannTizioto, Polyana CristineSilva Diniz, Wellison Jarles daLima, Andressa Oliveira dePereira Rocha, Marina IbelliBuss, Carlos EduardoNascimento Andrade, Bruno GabrielPiaya, OtavioSilva, Juliana Virginio daLins, Laura Albuquerque [UNESP]Gromboni, Caio FernandoAraujo Nogueira, Ana RitaSalinas Fortes, Marina RufinoMourao, Gerson BarretoAlmeida Regitano, Luciana Correia de2019-10-04T12:15:56Z2019-10-04T12:15:56Z2019-09-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11http://dx.doi.org/10.1038/s41598-019-49089-xScientific Reports. London: Nature Publishing Group, v. 9, 11 p., 2019.2045-2322http://hdl.handle.net/11449/18468410.1038/s41598-019-49089-xWOS:000483700400048Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2021-10-23T05:33:06Zoai:repositorio.unesp.br:11449/184684Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:54:28.021916Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
title Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
spellingShingle Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
Afonso, Juliana
title_short Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
title_full Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
title_fullStr Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
title_full_unstemmed Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
title_sort Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indices
author Afonso, Juliana
author_facet Afonso, Juliana
Coutinho, Luiz Lehmann
Tizioto, Polyana Cristine
Silva Diniz, Wellison Jarles da
Lima, Andressa Oliveira de
Pereira Rocha, Marina Ibelli
Buss, Carlos Eduardo
Nascimento Andrade, Bruno Gabriel
Piaya, Otavio
Silva, Juliana Virginio da
Lins, Laura Albuquerque [UNESP]
Gromboni, Caio Fernando
Araujo Nogueira, Ana Rita
Salinas Fortes, Marina Rufino
Mourao, Gerson Barreto
Almeida Regitano, Luciana Correia de
author_role author
author2 Coutinho, Luiz Lehmann
Tizioto, Polyana Cristine
Silva Diniz, Wellison Jarles da
Lima, Andressa Oliveira de
Pereira Rocha, Marina Ibelli
Buss, Carlos Eduardo
Nascimento Andrade, Bruno Gabriel
Piaya, Otavio
Silva, Juliana Virginio da
Lins, Laura Albuquerque [UNESP]
Gromboni, Caio Fernando
Araujo Nogueira, Ana Rita
Salinas Fortes, Marina Rufino
Mourao, Gerson Barreto
Almeida Regitano, Luciana Correia de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Carlos (UFSCar)
Universidade de São Paulo (USP)
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Universidade Estadual Paulista (Unesp)
Bahia Fed Inst Educ Sci & Technol
Univ Queensland
NGS Solucoes Genom
dc.contributor.author.fl_str_mv Afonso, Juliana
Coutinho, Luiz Lehmann
Tizioto, Polyana Cristine
Silva Diniz, Wellison Jarles da
Lima, Andressa Oliveira de
Pereira Rocha, Marina Ibelli
Buss, Carlos Eduardo
Nascimento Andrade, Bruno Gabriel
Piaya, Otavio
Silva, Juliana Virginio da
Lins, Laura Albuquerque [UNESP]
Gromboni, Caio Fernando
Araujo Nogueira, Ana Rita
Salinas Fortes, Marina Rufino
Mourao, Gerson Barreto
Almeida Regitano, Luciana Correia de
description Mineral content affects the biological processes underlying beef quality. Muscle mineral concentration depends not only on intake-outtake balance and muscle type, but also on age, environment, breed, and genetic factors. To unveil the genetic factors involved in muscle mineral concentration, we applied a pairwise differential gene expression analysis in groups of Nelore steers genetically divergent for nine different mineral concentrations. Here, based on significant expression differences between contrasting groups, we presented candidate genes for the genetic regulation of mineral concentration in muscle. Functional enrichment and protein-protein interaction network analyses were carried out to search for gene regulatory processes concerning each mineral. The core genetic regulation for all minerals studied, except Zn, seems to rest on interactions between components of the extracellular matrix. Regulation of adipogenesis-related pathways was also significant in our results. Antagonistic patterns of gene expression for fatty acid metabolism-related genes may explain the Cu and Zn antagonistic effect on fatty acid accumulation. Our results shed light on the role of these minerals on cell function.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:15:56Z
2019-10-04T12:15:56Z
2019-09-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/s41598-019-49089-x
Scientific Reports. London: Nature Publishing Group, v. 9, 11 p., 2019.
2045-2322
http://hdl.handle.net/11449/184684
10.1038/s41598-019-49089-x
WOS:000483700400048
url http://dx.doi.org/10.1038/s41598-019-49089-x
http://hdl.handle.net/11449/184684
identifier_str_mv Scientific Reports. London: Nature Publishing Group, v. 9, 11 p., 2019.
2045-2322
10.1038/s41598-019-49089-x
WOS:000483700400048
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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