Counteracting effects on free radicals and histological alterations induced by a fraction with casearins
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765201520150149 http://hdl.handle.net/11449/164922 |
Resumo: | Casearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestris and histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 mu g/mL) revealed EC50 values of 3.7, 6.4 and 0.16 mu g/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally administered to Swiss mice for 7 consecutive days. Nitrite levels in the hippocampus (26.2, 27.3, 30.2 and 26.6 mu M) and striatum (26.3, 25.4, 34.3 and 27.5 mu M) increased in all treated animals (P < 0.05). Lower doses dropped reduced glutathione, catalase and TBARS levels in the hippocampus and striatum. With the exception of this reduction in TBARS formation, FC displayed only in vitro antioxidant activity. Animals exhibited histological alterations suggestive of neurotoxicity and hepatotoxicity, indicating the need for precaution regarding the consumption of medicinal formulations based on Casearia sylvestris. |
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Counteracting effects on free radicals and histological alterations induced by a fraction with casearinsClerodane diterpenesCasearia sylvestrisantioxidantmorphological changestoxicityCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestris and histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 mu g/mL) revealed EC50 values of 3.7, 6.4 and 0.16 mu g/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally administered to Swiss mice for 7 consecutive days. Nitrite levels in the hippocampus (26.2, 27.3, 30.2 and 26.6 mu M) and striatum (26.3, 25.4, 34.3 and 27.5 mu M) increased in all treated animals (P < 0.05). Lower doses dropped reduced glutathione, catalase and TBARS levels in the hippocampus and striatum. With the exception of this reduction in TBARS formation, FC displayed only in vitro antioxidant activity. Animals exhibited histological alterations suggestive of neurotoxicity and hepatotoxicity, indicating the need for precaution regarding the consumption of medicinal formulations based on Casearia sylvestris.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao de Amparo a Pesquisa do Estado do Piaui (FAPEPI)Univ Fed Piaui, Programa Posgrad Ciencias Farmaceut, BR-64049550 Teresina, PI, BrazilUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, BrazilUniv Estadual Ceara, Fac Med Vet, BR-60000000 Fortaleza, Ceara, BrazilUniv Fed Piaui, Dept Ciencias Biol, BR-64607670 Picos, PI, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilUniv Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, BrazilUniv Fed Piaui, Dept Biofis & Fisiol, BR-64049550 Teresina, PI, BrazilUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilCNPq: 484286/2011-0Fundacao de Amparo a Pesquisa do Estado do Piaui (FAPEPI): 034/2012-PPPAcad Brasileira De CienciasUniv Fed PiauiUniversidade Estadual Paulista (Unesp)Univ Estadual CearaUniv Fed CearaFerreira De Araujo, Everton JoseLopes De Oliveira, Guilherme AntonioDe Sousa, Livia QueirozBolzani, Vanderlan Da Silva [UNESP]Cavalheiro, Alberto Jose [UNESP]Tome, Adriana Da RochaPeron, Ana PaulaDos Santos, Andre Gonzaga [UNESP]Das Gracas Lopes Cito, Antonia MariaPessoa, ClaudiaDe Freitas, Rivelilson MendesPinheiro Ferreira, Paulo Michel2018-11-27T01:47:17Z2018-11-27T01:47:17Z2015-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1791-1807application/pdfhttp://dx.doi.org/10.1590/0001-3765201520150149Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 87, n. 3, p. 1791-1807, 2015.0001-3765http://hdl.handle.net/11449/16492210.1590/0001-3765201520150149S0001-37652015000401791WOS:000361842000025S0001-37652015000401791.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Da Academia Brasileira De Ciencias0,418info:eu-repo/semantics/openAccess2023-12-17T06:15:26Zoai:repositorio.unesp.br:11449/164922Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:32:11.259094Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
title |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
spellingShingle |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins Ferreira De Araujo, Everton Jose Clerodane diterpenes Casearia sylvestris antioxidant morphological changes toxicity |
title_short |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
title_full |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
title_fullStr |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
title_full_unstemmed |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
title_sort |
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins |
author |
Ferreira De Araujo, Everton Jose |
author_facet |
Ferreira De Araujo, Everton Jose Lopes De Oliveira, Guilherme Antonio De Sousa, Livia Queiroz Bolzani, Vanderlan Da Silva [UNESP] Cavalheiro, Alberto Jose [UNESP] Tome, Adriana Da Rocha Peron, Ana Paula Dos Santos, Andre Gonzaga [UNESP] Das Gracas Lopes Cito, Antonia Maria Pessoa, Claudia De Freitas, Rivelilson Mendes Pinheiro Ferreira, Paulo Michel |
author_role |
author |
author2 |
Lopes De Oliveira, Guilherme Antonio De Sousa, Livia Queiroz Bolzani, Vanderlan Da Silva [UNESP] Cavalheiro, Alberto Jose [UNESP] Tome, Adriana Da Rocha Peron, Ana Paula Dos Santos, Andre Gonzaga [UNESP] Das Gracas Lopes Cito, Antonia Maria Pessoa, Claudia De Freitas, Rivelilson Mendes Pinheiro Ferreira, Paulo Michel |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Piaui Universidade Estadual Paulista (Unesp) Univ Estadual Ceara Univ Fed Ceara |
dc.contributor.author.fl_str_mv |
Ferreira De Araujo, Everton Jose Lopes De Oliveira, Guilherme Antonio De Sousa, Livia Queiroz Bolzani, Vanderlan Da Silva [UNESP] Cavalheiro, Alberto Jose [UNESP] Tome, Adriana Da Rocha Peron, Ana Paula Dos Santos, Andre Gonzaga [UNESP] Das Gracas Lopes Cito, Antonia Maria Pessoa, Claudia De Freitas, Rivelilson Mendes Pinheiro Ferreira, Paulo Michel |
dc.subject.por.fl_str_mv |
Clerodane diterpenes Casearia sylvestris antioxidant morphological changes toxicity |
topic |
Clerodane diterpenes Casearia sylvestris antioxidant morphological changes toxicity |
description |
Casearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestris and histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 mu g/mL) revealed EC50 values of 3.7, 6.4 and 0.16 mu g/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally administered to Swiss mice for 7 consecutive days. Nitrite levels in the hippocampus (26.2, 27.3, 30.2 and 26.6 mu M) and striatum (26.3, 25.4, 34.3 and 27.5 mu M) increased in all treated animals (P < 0.05). Lower doses dropped reduced glutathione, catalase and TBARS levels in the hippocampus and striatum. With the exception of this reduction in TBARS formation, FC displayed only in vitro antioxidant activity. Animals exhibited histological alterations suggestive of neurotoxicity and hepatotoxicity, indicating the need for precaution regarding the consumption of medicinal formulations based on Casearia sylvestris. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-01 2018-11-27T01:47:17Z 2018-11-27T01:47:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765201520150149 Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 87, n. 3, p. 1791-1807, 2015. 0001-3765 http://hdl.handle.net/11449/164922 10.1590/0001-3765201520150149 S0001-37652015000401791 WOS:000361842000025 S0001-37652015000401791.pdf |
url |
http://dx.doi.org/10.1590/0001-3765201520150149 http://hdl.handle.net/11449/164922 |
identifier_str_mv |
Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 87, n. 3, p. 1791-1807, 2015. 0001-3765 10.1590/0001-3765201520150149 S0001-37652015000401791 WOS:000361842000025 S0001-37652015000401791.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais Da Academia Brasileira De Ciencias 0,418 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1791-1807 application/pdf |
dc.publisher.none.fl_str_mv |
Acad Brasileira De Ciencias |
publisher.none.fl_str_mv |
Acad Brasileira De Ciencias |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129215661342720 |