Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2196/27843 http://hdl.handle.net/11449/230229 |
Resumo: | Background: The sensitivity of teeth with molar incisor hypomineralization (MIH) can affect children s quality of life and is a challenging problem for dentists. Remineralizing agents such as sodium fluoride varnish seem to reduce the sensitivity of teeth with MIH, but long-Term clinical trials with large samples are still needed for more evidence about its effectiveness as a desensitizing agent before its clinical recommendation. Objective: This randomized clinical trial aims to compare three treatment interventions for teeth with MIH and hypersensitivity. Methods: A total of 60 children aged 6-10 years presenting with at least one first permanent molar with sensitivity and no loss of enamel will be randomly assigned to three groups: The control group (sodium fluoride varnish; Duraphat, Colgate); experimental group I (4% titanium tetrafluoride varnish); and experimental group II (a coating resin containing surface prereacted glass-ionomer filler; PRG Barrier Coat, Shofu). The sodium fluoride varnish and 4% titanium tetrafluoride varnish will be applied once per week for 4 consecutive weeks and the PRG Barrier Coat resin will be applied in the first session and the application will be simulated the following 3 weeks to guarantee the blinding of the study. The primary outcome will be sensitivity level measured at different moments (before each material application, immediately after application or simulation, and 1, 2, 4, and 6 months after the last application/simulation) by one examiner using the Wong-Baker FACES Pain Rating Scale, the Schiff Cold Air Sensitivity Scale, and the FLACC (Face, Legs, Activity, Cry, Consolability) scale. As secondary outcomes, parental satisfaction and child self-reported discomfort after the treatment will be measured with a questionnaire prepared by the researcher. The data will undergo statistical analysis and the significance level will be set at 5%. Results: The project was funded in 2018, and enrollment was completed in November 2019. The recruitment of participants is currently underway and the first results are expected to be submitted for publication in 2022. Conclusions: If found effective in reducing the patient s sensitivity long term, these agents can be considered as a treatment choice, and the findings will contribute to the development of a treatment protocol for teeth with sensitivity due to MIH. |
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Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trialdental caredentistryfluoridemolar incisor hypomineralizationpediatric dentistrysensitivityBackground: The sensitivity of teeth with molar incisor hypomineralization (MIH) can affect children s quality of life and is a challenging problem for dentists. Remineralizing agents such as sodium fluoride varnish seem to reduce the sensitivity of teeth with MIH, but long-Term clinical trials with large samples are still needed for more evidence about its effectiveness as a desensitizing agent before its clinical recommendation. Objective: This randomized clinical trial aims to compare three treatment interventions for teeth with MIH and hypersensitivity. Methods: A total of 60 children aged 6-10 years presenting with at least one first permanent molar with sensitivity and no loss of enamel will be randomly assigned to three groups: The control group (sodium fluoride varnish; Duraphat, Colgate); experimental group I (4% titanium tetrafluoride varnish); and experimental group II (a coating resin containing surface prereacted glass-ionomer filler; PRG Barrier Coat, Shofu). The sodium fluoride varnish and 4% titanium tetrafluoride varnish will be applied once per week for 4 consecutive weeks and the PRG Barrier Coat resin will be applied in the first session and the application will be simulated the following 3 weeks to guarantee the blinding of the study. The primary outcome will be sensitivity level measured at different moments (before each material application, immediately after application or simulation, and 1, 2, 4, and 6 months after the last application/simulation) by one examiner using the Wong-Baker FACES Pain Rating Scale, the Schiff Cold Air Sensitivity Scale, and the FLACC (Face, Legs, Activity, Cry, Consolability) scale. As secondary outcomes, parental satisfaction and child self-reported discomfort after the treatment will be measured with a questionnaire prepared by the researcher. The data will undergo statistical analysis and the significance level will be set at 5%. Results: The project was funded in 2018, and enrollment was completed in November 2019. The recruitment of participants is currently underway and the first results are expected to be submitted for publication in 2022. Conclusions: If found effective in reducing the patient s sensitivity long term, these agents can be considered as a treatment choice, and the findings will contribute to the development of a treatment protocol for teeth with sensitivity due to MIH.Department of Pediatric Dentistry Orthodontics and Public Health Bauru School of Dentistry University of São PauloMorphology and Children's Clinic Department Araraquara Dental School São Paulo State UniversityDepartment of Biological Sciences Bauru School of Dentistry University of São PauloMorphology and Children's Clinic Department Araraquara Dental School São Paulo State UniversityUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Mendonça, Fernanda LDi Campli Regnault, Fabiana GiuseppinaDi Leone, Camilla C LGrizzo, Isabella CBisaia, AlinyFragelli, Camila [UNESP]Oliveira, Thais MMagalhães, Ana CRios, Daniela2022-04-29T08:38:39Z2022-04-29T08:38:39Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.2196/27843JMIR Research Protocols, v. 11, n. 1, 2022.1929-0748http://hdl.handle.net/11449/23022910.2196/278432-s2.0-85122938845Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJMIR Research Protocolsinfo:eu-repo/semantics/openAccess2022-04-29T08:38:39Zoai:repositorio.unesp.br:11449/230229Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:40:00.633436Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
title |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
spellingShingle |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial Mendonça, Fernanda L dental care dentistry fluoride molar incisor hypomineralization pediatric dentistry sensitivity |
title_short |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
title_full |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
title_fullStr |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
title_full_unstemmed |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
title_sort |
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial |
author |
Mendonça, Fernanda L |
author_facet |
Mendonça, Fernanda L Di Campli Regnault, Fabiana Giuseppina Di Leone, Camilla C L Grizzo, Isabella C Bisaia, Aliny Fragelli, Camila [UNESP] Oliveira, Thais M Magalhães, Ana C Rios, Daniela |
author_role |
author |
author2 |
Di Campli Regnault, Fabiana Giuseppina Di Leone, Camilla C L Grizzo, Isabella C Bisaia, Aliny Fragelli, Camila [UNESP] Oliveira, Thais M Magalhães, Ana C Rios, Daniela |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Mendonça, Fernanda L Di Campli Regnault, Fabiana Giuseppina Di Leone, Camilla C L Grizzo, Isabella C Bisaia, Aliny Fragelli, Camila [UNESP] Oliveira, Thais M Magalhães, Ana C Rios, Daniela |
dc.subject.por.fl_str_mv |
dental care dentistry fluoride molar incisor hypomineralization pediatric dentistry sensitivity |
topic |
dental care dentistry fluoride molar incisor hypomineralization pediatric dentistry sensitivity |
description |
Background: The sensitivity of teeth with molar incisor hypomineralization (MIH) can affect children s quality of life and is a challenging problem for dentists. Remineralizing agents such as sodium fluoride varnish seem to reduce the sensitivity of teeth with MIH, but long-Term clinical trials with large samples are still needed for more evidence about its effectiveness as a desensitizing agent before its clinical recommendation. Objective: This randomized clinical trial aims to compare three treatment interventions for teeth with MIH and hypersensitivity. Methods: A total of 60 children aged 6-10 years presenting with at least one first permanent molar with sensitivity and no loss of enamel will be randomly assigned to three groups: The control group (sodium fluoride varnish; Duraphat, Colgate); experimental group I (4% titanium tetrafluoride varnish); and experimental group II (a coating resin containing surface prereacted glass-ionomer filler; PRG Barrier Coat, Shofu). The sodium fluoride varnish and 4% titanium tetrafluoride varnish will be applied once per week for 4 consecutive weeks and the PRG Barrier Coat resin will be applied in the first session and the application will be simulated the following 3 weeks to guarantee the blinding of the study. The primary outcome will be sensitivity level measured at different moments (before each material application, immediately after application or simulation, and 1, 2, 4, and 6 months after the last application/simulation) by one examiner using the Wong-Baker FACES Pain Rating Scale, the Schiff Cold Air Sensitivity Scale, and the FLACC (Face, Legs, Activity, Cry, Consolability) scale. As secondary outcomes, parental satisfaction and child self-reported discomfort after the treatment will be measured with a questionnaire prepared by the researcher. The data will undergo statistical analysis and the significance level will be set at 5%. Results: The project was funded in 2018, and enrollment was completed in November 2019. The recruitment of participants is currently underway and the first results are expected to be submitted for publication in 2022. Conclusions: If found effective in reducing the patient s sensitivity long term, these agents can be considered as a treatment choice, and the findings will contribute to the development of a treatment protocol for teeth with sensitivity due to MIH. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:38:39Z 2022-04-29T08:38:39Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2196/27843 JMIR Research Protocols, v. 11, n. 1, 2022. 1929-0748 http://hdl.handle.net/11449/230229 10.2196/27843 2-s2.0-85122938845 |
url |
http://dx.doi.org/10.2196/27843 http://hdl.handle.net/11449/230229 |
identifier_str_mv |
JMIR Research Protocols, v. 11, n. 1, 2022. 1929-0748 10.2196/27843 2-s2.0-85122938845 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
JMIR Research Protocols |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128963718938624 |