Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765202120200899 http://hdl.handle.net/11449/221791 |
Resumo: | Cardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks. During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited significant changes in blood pressure, lipid profile, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These findings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors. |
id |
UNSP_7bde959d8df1fdbd720d554115d242e9 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/221791 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseasesAsteraceaeCarquejaDyslipidemiaHerbal medicineHypertensionSmokingCardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks. During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited significant changes in blood pressure, lipid profile, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These findings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors.Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do SulUniversidade Paranaense Laboratório de Pesquisa Pré-Clínica de Produtos Naturais Praça Mascarenhas de Moraes, 4282, Caixa Postal 224Universidade Federal da Grande Dourados Faculdade de Ciências da Saúde Laboratório de Farmacologia Cardiovascular, Rodovia Dourados-Itahum,, Km 12, Caixa Postal 533Faculdade Assis Gurgacz Laboratório de Prevenção e Diagnóstico Avenida das Torres, 500Universidade Paranaense Laboratório de Neurociências Praça Mascarenhas de Moraes, 4282, Caixa Postal 224Universidade Estadual de São Paulo Departamento de Biotecnologia Laboratório de Genética e Terapia Celular, Avenida Dom AntonioUniversidade Estadual de São Paulo Departamento de Biotecnologia Laboratório de Genética e Terapia Celular, Avenida Dom AntonioFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul: 59/300351/2016Praça Mascarenhas de MoraesLaboratório de Farmacologia CardiovascularAvenida das TorresUniversidade Estadual Paulista (UNESP)Mendes, Tatiane C.DA SILVA, Gustavo R.Silva, Aniely O.Schaedler, Maysa I.Guarnier, Lucas P.Palozi, Rhanany A. C.Signor, Cleide T.Dal Bosco, Janaína D.Auth, Pablo A.Amaral, Eduarda C.Froelich, Diego L.Soares, Andréia A.Lovato, Evellyn C. W.Ribeiro-Paes, João T. [UNESP]Gasparotto Junior, ArquimedesDos Reis Lívero, Francislaine A.2022-04-28T19:40:25Z2022-04-28T19:40:25Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0001-3765202120200899Anais da Academia Brasileira de Ciencias, v. 93, n. 3, 2021.1678-26900001-3765http://hdl.handle.net/11449/22179110.1590/0001-37652021202008992-s2.0-85108091427Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2022-04-28T19:40:25Zoai:repositorio.unesp.br:11449/221791Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:47:40.104742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
title |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
spellingShingle |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases Mendes, Tatiane C. Asteraceae Carqueja Dyslipidemia Herbal medicine Hypertension Smoking |
title_short |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
title_full |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
title_fullStr |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
title_full_unstemmed |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
title_sort |
Hepato-and cardioprotective effects of baccharis trimera (Less.) dc. against multiple risk factors for chronic noncommunicable diseases |
author |
Mendes, Tatiane C. |
author_facet |
Mendes, Tatiane C. DA SILVA, Gustavo R. Silva, Aniely O. Schaedler, Maysa I. Guarnier, Lucas P. Palozi, Rhanany A. C. Signor, Cleide T. Dal Bosco, Janaína D. Auth, Pablo A. Amaral, Eduarda C. Froelich, Diego L. Soares, Andréia A. Lovato, Evellyn C. W. Ribeiro-Paes, João T. [UNESP] Gasparotto Junior, Arquimedes Dos Reis Lívero, Francislaine A. |
author_role |
author |
author2 |
DA SILVA, Gustavo R. Silva, Aniely O. Schaedler, Maysa I. Guarnier, Lucas P. Palozi, Rhanany A. C. Signor, Cleide T. Dal Bosco, Janaína D. Auth, Pablo A. Amaral, Eduarda C. Froelich, Diego L. Soares, Andréia A. Lovato, Evellyn C. W. Ribeiro-Paes, João T. [UNESP] Gasparotto Junior, Arquimedes Dos Reis Lívero, Francislaine A. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Praça Mascarenhas de Moraes Laboratório de Farmacologia Cardiovascular Avenida das Torres Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Mendes, Tatiane C. DA SILVA, Gustavo R. Silva, Aniely O. Schaedler, Maysa I. Guarnier, Lucas P. Palozi, Rhanany A. C. Signor, Cleide T. Dal Bosco, Janaína D. Auth, Pablo A. Amaral, Eduarda C. Froelich, Diego L. Soares, Andréia A. Lovato, Evellyn C. W. Ribeiro-Paes, João T. [UNESP] Gasparotto Junior, Arquimedes Dos Reis Lívero, Francislaine A. |
dc.subject.por.fl_str_mv |
Asteraceae Carqueja Dyslipidemia Herbal medicine Hypertension Smoking |
topic |
Asteraceae Carqueja Dyslipidemia Herbal medicine Hypertension Smoking |
description |
Cardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks. During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited significant changes in blood pressure, lipid profile, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These findings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:40:25Z 2022-04-28T19:40:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765202120200899 Anais da Academia Brasileira de Ciencias, v. 93, n. 3, 2021. 1678-2690 0001-3765 http://hdl.handle.net/11449/221791 10.1590/0001-3765202120200899 2-s2.0-85108091427 |
url |
http://dx.doi.org/10.1590/0001-3765202120200899 http://hdl.handle.net/11449/221791 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 93, n. 3, 2021. 1678-2690 0001-3765 10.1590/0001-3765202120200899 2-s2.0-85108091427 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128702048894976 |