The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running

Detalhes bibliográficos
Autor(a) principal: de Lima, Leonardo Coelho Rabello [UNESP]
Data de Publicação: 2021
Outros Autores: Bueno Junior, Carlos Roberto, de Oliveira Assumpção, Claudio [UNESP], de Menezes Bassan, Natália [UNESP], Barreto, Renan Vieira [UNESP], Cardozo, Adalgiso Coscrato [UNESP], Greco, Camila Coelho [UNESP], Denadai, Benedito Sérgio [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3389/fphys.2021.769971
http://hdl.handle.net/11449/233870
Resumo: This study aimed to investigate if ACTN3 gene polymorphism impacts the susceptibility to exercise-induced muscle damage (EIMD) and changes in running economy (RE) following downhill running. Thirty-five healthy men were allocated to the two groups based on their ACTN3 gene variants: RR and X allele carriers. Neuromuscular function [knee extensor isometric peak torque (IPT), rate of torque development (RTD), and countermovement, and squat jump height], indirect markers of EIMD [muscle soreness, mid-thigh circumference, knee joint range of motion, and serum creatine kinase (CK) activity], and RE (oxygen uptake, minute ventilation, blood lactate concentration, and perceived exertion) for 5-min of running at a speed equivalent to 80% of individual maximal oxygen uptake speed were assessed before, immediately after, and 1–4 days after a 30-min downhill run (−15%). Neuromuscular function was compromised (P < 0.05) following downhill running with no differences between the groups, except for IPT, which was more affected in the RR individuals compared with the X allele carriers immediately (−24.9 ± 6.9% vs. −16.3 ± 6.5%, respectively) and 4 days (−16.6 ± 14.9% vs. −4.2 ± 9.5%, respectively) post-downhill running. EIMD manifested similarly for both the groups except for serum CK activity, which was greater for RR (398 ± 120 and 452 ± 126 U L–1 at 2 and 4 days following downhill running, respectively) compared with the X allele carriers (273 ± 121 and 352 ± 114 U L–1 at the same time points). RE was compromised following downhill running (16.7 ± 8.3% and 11 ± 7.5% increases in oxygen uptake immediately following downhill running for the RR and X allele carriers, respectively) with no difference between the groups. We conclude that although RR individuals appear to be more susceptible to EIMD following downhill running, this does not extend to the changes in RE.
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spelling The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill RunningACTN3downhillgene polymorphismmuscle damagerecoveryrunningrunning economystrengthThis study aimed to investigate if ACTN3 gene polymorphism impacts the susceptibility to exercise-induced muscle damage (EIMD) and changes in running economy (RE) following downhill running. Thirty-five healthy men were allocated to the two groups based on their ACTN3 gene variants: RR and X allele carriers. Neuromuscular function [knee extensor isometric peak torque (IPT), rate of torque development (RTD), and countermovement, and squat jump height], indirect markers of EIMD [muscle soreness, mid-thigh circumference, knee joint range of motion, and serum creatine kinase (CK) activity], and RE (oxygen uptake, minute ventilation, blood lactate concentration, and perceived exertion) for 5-min of running at a speed equivalent to 80% of individual maximal oxygen uptake speed were assessed before, immediately after, and 1–4 days after a 30-min downhill run (−15%). Neuromuscular function was compromised (P < 0.05) following downhill running with no differences between the groups, except for IPT, which was more affected in the RR individuals compared with the X allele carriers immediately (−24.9 ± 6.9% vs. −16.3 ± 6.5%, respectively) and 4 days (−16.6 ± 14.9% vs. −4.2 ± 9.5%, respectively) post-downhill running. EIMD manifested similarly for both the groups except for serum CK activity, which was greater for RR (398 ± 120 and 452 ± 126 U L–1 at 2 and 4 days following downhill running, respectively) compared with the X allele carriers (273 ± 121 and 352 ± 114 U L–1 at the same time points). RE was compromised following downhill running (16.7 ± 8.3% and 11 ± 7.5% increases in oxygen uptake immediately following downhill running for the RR and X allele carriers, respectively) with no difference between the groups. We conclude that although RR individuals appear to be more susceptible to EIMD following downhill running, this does not extend to the changes in RE.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Human Performance Laboratory Department of Physical Education São Paulo State UniversityFaculty of Biological and Health Sciences School of Physical Education Centro Universitário da Fundação Hermínio OmettoSchool of Physical Education Centro Universitário Salesiano de São Paulo, Campus Liceu SalesianoSchool of Physical Education and Sport University of São PauloPhysical Education and Sports Institute Federal University of CearáBiomechanics Laboratory Department of Physical Education São Paulo State UniversityHuman Performance Laboratory Department of Physical Education São Paulo State UniversityBiomechanics Laboratory Department of Physical Education São Paulo State UniversityFAPESP: 2013/23585-4Universidade Estadual Paulista (UNESP)Centro Universitário da Fundação Hermínio OmettoCentro Universitário Salesiano de São PauloUniversidade de São Paulo (USP)Federal University of Cearáde Lima, Leonardo Coelho Rabello [UNESP]Bueno Junior, Carlos Robertode Oliveira Assumpção, Claudio [UNESP]de Menezes Bassan, Natália [UNESP]Barreto, Renan Vieira [UNESP]Cardozo, Adalgiso Coscrato [UNESP]Greco, Camila Coelho [UNESP]Denadai, Benedito Sérgio [UNESP]2022-05-01T11:07:36Z2022-05-01T11:07:36Z2021-11-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fphys.2021.769971Frontiers in Physiology, v. 12.1664-042Xhttp://hdl.handle.net/11449/23387010.3389/fphys.2021.7699712-s2.0-85120553750Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Physiologyinfo:eu-repo/semantics/openAccess2022-05-01T11:07:36Zoai:repositorio.unesp.br:11449/233870Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:44:19.797800Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
title The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
spellingShingle The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
de Lima, Leonardo Coelho Rabello [UNESP]
ACTN3
downhill
gene polymorphism
muscle damage
recovery
running
running economy
strength
title_short The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
title_full The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
title_fullStr The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
title_full_unstemmed The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
title_sort The Impact of ACTN3 Gene Polymorphisms on Susceptibility to Exercise-Induced Muscle Damage and Changes in Running Economy Following Downhill Running
author de Lima, Leonardo Coelho Rabello [UNESP]
author_facet de Lima, Leonardo Coelho Rabello [UNESP]
Bueno Junior, Carlos Roberto
de Oliveira Assumpção, Claudio [UNESP]
de Menezes Bassan, Natália [UNESP]
Barreto, Renan Vieira [UNESP]
Cardozo, Adalgiso Coscrato [UNESP]
Greco, Camila Coelho [UNESP]
Denadai, Benedito Sérgio [UNESP]
author_role author
author2 Bueno Junior, Carlos Roberto
de Oliveira Assumpção, Claudio [UNESP]
de Menezes Bassan, Natália [UNESP]
Barreto, Renan Vieira [UNESP]
Cardozo, Adalgiso Coscrato [UNESP]
Greco, Camila Coelho [UNESP]
Denadai, Benedito Sérgio [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Centro Universitário da Fundação Hermínio Ometto
Centro Universitário Salesiano de São Paulo
Universidade de São Paulo (USP)
Federal University of Ceará
dc.contributor.author.fl_str_mv de Lima, Leonardo Coelho Rabello [UNESP]
Bueno Junior, Carlos Roberto
de Oliveira Assumpção, Claudio [UNESP]
de Menezes Bassan, Natália [UNESP]
Barreto, Renan Vieira [UNESP]
Cardozo, Adalgiso Coscrato [UNESP]
Greco, Camila Coelho [UNESP]
Denadai, Benedito Sérgio [UNESP]
dc.subject.por.fl_str_mv ACTN3
downhill
gene polymorphism
muscle damage
recovery
running
running economy
strength
topic ACTN3
downhill
gene polymorphism
muscle damage
recovery
running
running economy
strength
description This study aimed to investigate if ACTN3 gene polymorphism impacts the susceptibility to exercise-induced muscle damage (EIMD) and changes in running economy (RE) following downhill running. Thirty-five healthy men were allocated to the two groups based on their ACTN3 gene variants: RR and X allele carriers. Neuromuscular function [knee extensor isometric peak torque (IPT), rate of torque development (RTD), and countermovement, and squat jump height], indirect markers of EIMD [muscle soreness, mid-thigh circumference, knee joint range of motion, and serum creatine kinase (CK) activity], and RE (oxygen uptake, minute ventilation, blood lactate concentration, and perceived exertion) for 5-min of running at a speed equivalent to 80% of individual maximal oxygen uptake speed were assessed before, immediately after, and 1–4 days after a 30-min downhill run (−15%). Neuromuscular function was compromised (P < 0.05) following downhill running with no differences between the groups, except for IPT, which was more affected in the RR individuals compared with the X allele carriers immediately (−24.9 ± 6.9% vs. −16.3 ± 6.5%, respectively) and 4 days (−16.6 ± 14.9% vs. −4.2 ± 9.5%, respectively) post-downhill running. EIMD manifested similarly for both the groups except for serum CK activity, which was greater for RR (398 ± 120 and 452 ± 126 U L–1 at 2 and 4 days following downhill running, respectively) compared with the X allele carriers (273 ± 121 and 352 ± 114 U L–1 at the same time points). RE was compromised following downhill running (16.7 ± 8.3% and 11 ± 7.5% increases in oxygen uptake immediately following downhill running for the RR and X allele carriers, respectively) with no difference between the groups. We conclude that although RR individuals appear to be more susceptible to EIMD following downhill running, this does not extend to the changes in RE.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-15
2022-05-01T11:07:36Z
2022-05-01T11:07:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fphys.2021.769971
Frontiers in Physiology, v. 12.
1664-042X
http://hdl.handle.net/11449/233870
10.3389/fphys.2021.769971
2-s2.0-85120553750
url http://dx.doi.org/10.3389/fphys.2021.769971
http://hdl.handle.net/11449/233870
identifier_str_mv Frontiers in Physiology, v. 12.
1664-042X
10.3389/fphys.2021.769971
2-s2.0-85120553750
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Physiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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