Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.carbpol.2017.09.019 http://hdl.handle.net/11449/163394 |
Resumo: | This study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy (C-13 NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5.27 nm. The entrapment of iron oxide nanoparticles in a dextran nanohydrogel matrix was confirmed by thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and Zeta potential data. The magnetic nanohydrogels presented superparamagnetic behavior and were colloidal stable in physiological during 30 days. Our findings suggest that the synthesized magnetic nanohydrogel are potential candidates for use in drug delivery systems due to its physicochemical and magnetic properties. |
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Repositório Institucional da UNESP |
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Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextranDerivatized dextranNanohydrogelsIron oxideMiniemulsion polymerizationThis study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy (C-13 NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5.27 nm. The entrapment of iron oxide nanoparticles in a dextran nanohydrogel matrix was confirmed by thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and Zeta potential data. The magnetic nanohydrogels presented superparamagnetic behavior and were colloidal stable in physiological during 30 days. Our findings suggest that the synthesized magnetic nanohydrogel are potential candidates for use in drug delivery systems due to its physicochemical and magnetic properties.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Brazilian Innovation Agency (FINEP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sao Paulo State Univ, Inst Chem, Dept Phys Chem, Lab Magnet Mat & Colloids, BR-14801970 Araraquara, SP, BrazilInst Fed Goiano, BR-75901970 Rio Verde, Go, BrazilUniv Brasilia, Inst Fis, Nucleo Fis Aplicada, BR-70910900 Brasilia, DF, BrazilAnhui Univ, Sch Chem & Chem Engn, Hefei 230601, Anhui, Peoples R ChinaSao Paulo State Univ, Inst Chem, Dept Phys Chem, Lab Magnet Mat & Colloids, BR-14801970 Araraquara, SP, BrazilElsevier B.V.Universidade Estadual Paulista (Unesp)Inst Fed GoianoUniversidade de Brasília (UnB)Anhui UnivPiazza, Rodolfo Debone [UNESP]Nunes, Eloiza da SilvaViali, Wesley RenatoSilva, Sebastiao William daAragon, Fermin HerreraHuamani Coaquira, Jose AntonioMorais, Paulo Cesar deCosta Marques, Rodrigo Fernando [UNESP]Jafelicci Junior, Miguel [UNESP]2018-11-26T17:41:50Z2018-11-26T17:41:50Z2017-12-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article378-385application/pdfhttp://dx.doi.org/10.1016/j.carbpol.2017.09.019Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 178, p. 378-385, 2017.0144-8617http://hdl.handle.net/11449/16339410.1016/j.carbpol.2017.09.019WOS:000413038000043WOS000413038000043.pdf7182671143702858Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymers1,428info:eu-repo/semantics/openAccess2023-11-26T06:16:17Zoai:repositorio.unesp.br:11449/163394Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:48:33.173966Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
title |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
spellingShingle |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran Piazza, Rodolfo Debone [UNESP] Derivatized dextran Nanohydrogels Iron oxide Miniemulsion polymerization |
title_short |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
title_full |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
title_fullStr |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
title_full_unstemmed |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
title_sort |
Magnetic nanohydrogel obtained by miniemulsion polymerization of poly (acrylic acid) grafted onto derivatized dextran |
author |
Piazza, Rodolfo Debone [UNESP] |
author_facet |
Piazza, Rodolfo Debone [UNESP] Nunes, Eloiza da Silva Viali, Wesley Renato Silva, Sebastiao William da Aragon, Fermin Herrera Huamani Coaquira, Jose Antonio Morais, Paulo Cesar de Costa Marques, Rodrigo Fernando [UNESP] Jafelicci Junior, Miguel [UNESP] |
author_role |
author |
author2 |
Nunes, Eloiza da Silva Viali, Wesley Renato Silva, Sebastiao William da Aragon, Fermin Herrera Huamani Coaquira, Jose Antonio Morais, Paulo Cesar de Costa Marques, Rodrigo Fernando [UNESP] Jafelicci Junior, Miguel [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Inst Fed Goiano Universidade de Brasília (UnB) Anhui Univ |
dc.contributor.author.fl_str_mv |
Piazza, Rodolfo Debone [UNESP] Nunes, Eloiza da Silva Viali, Wesley Renato Silva, Sebastiao William da Aragon, Fermin Herrera Huamani Coaquira, Jose Antonio Morais, Paulo Cesar de Costa Marques, Rodrigo Fernando [UNESP] Jafelicci Junior, Miguel [UNESP] |
dc.subject.por.fl_str_mv |
Derivatized dextran Nanohydrogels Iron oxide Miniemulsion polymerization |
topic |
Derivatized dextran Nanohydrogels Iron oxide Miniemulsion polymerization |
description |
This study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy (C-13 NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5.27 nm. The entrapment of iron oxide nanoparticles in a dextran nanohydrogel matrix was confirmed by thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and Zeta potential data. The magnetic nanohydrogels presented superparamagnetic behavior and were colloidal stable in physiological during 30 days. Our findings suggest that the synthesized magnetic nanohydrogel are potential candidates for use in drug delivery systems due to its physicochemical and magnetic properties. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-15 2018-11-26T17:41:50Z 2018-11-26T17:41:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.carbpol.2017.09.019 Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 178, p. 378-385, 2017. 0144-8617 http://hdl.handle.net/11449/163394 10.1016/j.carbpol.2017.09.019 WOS:000413038000043 WOS000413038000043.pdf 7182671143702858 |
url |
http://dx.doi.org/10.1016/j.carbpol.2017.09.019 http://hdl.handle.net/11449/163394 |
identifier_str_mv |
Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 178, p. 378-385, 2017. 0144-8617 10.1016/j.carbpol.2017.09.019 WOS:000413038000043 WOS000413038000043.pdf 7182671143702858 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carbohydrate Polymers 1,428 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
378-385 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128982511517696 |