Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components

Detalhes bibliográficos
Autor(a) principal: Carvalho, Flavio A. [UNESP]
Data de Publicação: 2018
Outros Autores: Uchina, Helena S. [UNESP], Borges, Felipe A. [UNESP], Oyafuso, Marcia H. [UNESP], Herculano, Rondinelli D. [UNESP], Gremiao, Maria P. D. [UNESP], Santos, Andre G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.bjp.2017.10.007
http://hdl.handle.net/11449/163926
Resumo: Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Miill.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the development of membranes of natural latex incorporated with C. sylvestris leaf derivatives (ethanolic extract, diterpene concentrated fraction and casearin J), their chemical and physical characterization, and the evaluation of in vitro skin permeation and retention of C. sylvestris bioactive secondary metabolites (diterpenes and phenolic compounds). The membranes were developed mixing hydroethanolic solutions of C. sylvestris derivatives with latex and drying them in a desiccator. They were characterized by infrared spectroscopy, scanning electron microscopy, water vapor permeability and mechanical resistance assays, demonstrating that all membranes were permeable, resistant and homogeneous in surfaces. The permeation and retention assays demonstrated dermal penetration of phenolic compounds for ethanolic extract membrane and of casearin-like clerodane diterpenes for all membranes, indicating that these membranes have great potential for therapeutical application as a topical system for C. sylvestris components releasing. (C) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.
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spelling Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf componentsDiterpenesCasearinPhenolic compoundsIn vitro permeationIn vitro retentionNatural latex membraneNatural latex from Hevea brasiliensis (Wild. ex A.Juss) Miill.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the development of membranes of natural latex incorporated with C. sylvestris leaf derivatives (ethanolic extract, diterpene concentrated fraction and casearin J), their chemical and physical characterization, and the evaluation of in vitro skin permeation and retention of C. sylvestris bioactive secondary metabolites (diterpenes and phenolic compounds). The membranes were developed mixing hydroethanolic solutions of C. sylvestris derivatives with latex and drying them in a desiccator. They were characterized by infrared spectroscopy, scanning electron microscopy, water vapor permeability and mechanical resistance assays, demonstrating that all membranes were permeable, resistant and homogeneous in surfaces. The permeation and retention assays demonstrated dermal penetration of phenolic compounds for ethanolic extract membrane and of casearin-like clerodane diterpenes for all membranes, indicating that these membranes have great potential for therapeutical application as a topical system for C. sylvestris components releasing. (C) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Scientific Support and Development Program of School of Pharmaceutical Sciences (Unesp)Univ Estadual Paulista, Lab Farmacognosia, Dept Principios Ativos Nat & Toxicol, Fac Ciencias Farmaceut, Araraquara, SP, BrazilUniv Estadual Paulista, Lab Biomat & Bioengn, Dept Bioproc & Biotecnol, Fac Ciencias Farmaceut, Araraquara, SP, BrazilUniv Estadual Paulista, Lab Farmacotecn & Tecnol Farmaceut, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, SP, BrazilUniv Estadual Paulista, Lab Farmacognosia, Dept Principios Ativos Nat & Toxicol, Fac Ciencias Farmaceut, Araraquara, SP, BrazilUniv Estadual Paulista, Lab Biomat & Bioengn, Dept Bioproc & Biotecnol, Fac Ciencias Farmaceut, Araraquara, SP, BrazilUniv Estadual Paulista, Lab Farmacotecn & Tecnol Farmaceut, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, SP, BrazilSoc Brasileira FarmacognosiaUniversidade Estadual Paulista (Unesp)Carvalho, Flavio A. [UNESP]Uchina, Helena S. [UNESP]Borges, Felipe A. [UNESP]Oyafuso, Marcia H. [UNESP]Herculano, Rondinelli D. [UNESP]Gremiao, Maria P. D. [UNESP]Santos, Andre G. [UNESP]2018-11-26T17:48:27Z2018-11-26T17:48:27Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article102-110application/pdfhttp://dx.doi.org/10.1016/j.bjp.2017.10.007Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 28, n. 1, p. 102-110, 2018.0102-695Xhttp://hdl.handle.net/11449/16392610.1016/j.bjp.2017.10.007S0102-695X2018000100102WOS:000426442500014S0102-695X2018000100102.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:41Zoai:repositorio.unesp.br:11449/163926Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:03:29.246834Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
title Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
spellingShingle Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
Carvalho, Flavio A. [UNESP]
Diterpenes
Casearin
Phenolic compounds
In vitro permeation
In vitro retention
Natural latex membrane
title_short Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
title_full Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
title_fullStr Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
title_full_unstemmed Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
title_sort Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
author Carvalho, Flavio A. [UNESP]
author_facet Carvalho, Flavio A. [UNESP]
Uchina, Helena S. [UNESP]
Borges, Felipe A. [UNESP]
Oyafuso, Marcia H. [UNESP]
Herculano, Rondinelli D. [UNESP]
Gremiao, Maria P. D. [UNESP]
Santos, Andre G. [UNESP]
author_role author
author2 Uchina, Helena S. [UNESP]
Borges, Felipe A. [UNESP]
Oyafuso, Marcia H. [UNESP]
Herculano, Rondinelli D. [UNESP]
Gremiao, Maria P. D. [UNESP]
Santos, Andre G. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Carvalho, Flavio A. [UNESP]
Uchina, Helena S. [UNESP]
Borges, Felipe A. [UNESP]
Oyafuso, Marcia H. [UNESP]
Herculano, Rondinelli D. [UNESP]
Gremiao, Maria P. D. [UNESP]
Santos, Andre G. [UNESP]
dc.subject.por.fl_str_mv Diterpenes
Casearin
Phenolic compounds
In vitro permeation
In vitro retention
Natural latex membrane
topic Diterpenes
Casearin
Phenolic compounds
In vitro permeation
In vitro retention
Natural latex membrane
description Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Miill.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the development of membranes of natural latex incorporated with C. sylvestris leaf derivatives (ethanolic extract, diterpene concentrated fraction and casearin J), their chemical and physical characterization, and the evaluation of in vitro skin permeation and retention of C. sylvestris bioactive secondary metabolites (diterpenes and phenolic compounds). The membranes were developed mixing hydroethanolic solutions of C. sylvestris derivatives with latex and drying them in a desiccator. They were characterized by infrared spectroscopy, scanning electron microscopy, water vapor permeability and mechanical resistance assays, demonstrating that all membranes were permeable, resistant and homogeneous in surfaces. The permeation and retention assays demonstrated dermal penetration of phenolic compounds for ethanolic extract membrane and of casearin-like clerodane diterpenes for all membranes, indicating that these membranes have great potential for therapeutical application as a topical system for C. sylvestris components releasing. (C) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-26T17:48:27Z
2018-11-26T17:48:27Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bjp.2017.10.007
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 28, n. 1, p. 102-110, 2018.
0102-695X
http://hdl.handle.net/11449/163926
10.1016/j.bjp.2017.10.007
S0102-695X2018000100102
WOS:000426442500014
S0102-695X2018000100102.pdf
url http://dx.doi.org/10.1016/j.bjp.2017.10.007
http://hdl.handle.net/11449/163926
identifier_str_mv Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 28, n. 1, p. 102-110, 2018.
0102-695X
10.1016/j.bjp.2017.10.007
S0102-695X2018000100102
WOS:000426442500014
S0102-695X2018000100102.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 102-110
application/pdf
dc.publisher.none.fl_str_mv Soc Brasileira Farmacognosia
publisher.none.fl_str_mv Soc Brasileira Farmacognosia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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