Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses

Detalhes bibliográficos
Autor(a) principal: Andrade, G. H.B. [UNESP]
Data de Publicação: 2018
Outros Autores: Simão, V. A. [UNESP], Souza, B. R. [UNESP], Chuffa, L. G.A. [UNESP], Camargo, I. C.C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tice.2018.01.001
http://hdl.handle.net/11449/170810
Resumo: Anabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods. The control group received mineral oil. Estrous cycle was monitored daily during both periods and in sequence the rats (n = 8/group/period) were killed. All ND-treated animals showed estral acyclicity during the PT and PR periods, but the histomorphometric changes in the fallopian tube varied according to the ND dose level. The expression of AR, ERα and ERβ varied in the nucleus and cytoplasm of epithelial cells. No AR expression was observed in the stroma. The muscle cells exhibited variation in immunostaining. In conclusion, ND promoted histomorphometric and immunohistochemical changes in the ampullary portion of the fallopian tube after treatment and recovery periods in a dose-independent manner.
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spelling Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analysesFallopian tubeNandrolone decanoateSex steroids receptorsAnabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods. The control group received mineral oil. Estrous cycle was monitored daily during both periods and in sequence the rats (n = 8/group/period) were killed. All ND-treated animals showed estral acyclicity during the PT and PR periods, but the histomorphometric changes in the fallopian tube varied according to the ND dose level. The expression of AR, ERα and ERβ varied in the nucleus and cytoplasm of epithelial cells. No AR expression was observed in the stroma. The muscle cells exhibited variation in immunostaining. In conclusion, ND promoted histomorphometric and immunohistochemical changes in the ampullary portion of the fallopian tube after treatment and recovery periods in a dose-independent manner.São Paulo State University – UNESP School of Sciences Humanities and Languages Department of BiotechnologySão Paulo State University – UNESP Institute of Biosciences Department of AnatomySão Paulo State University – UNESP School of Sciences Humanities and Languages Department of BiotechnologySão Paulo State University – UNESP Institute of Biosciences Department of AnatomyUniversidade Estadual Paulista (Unesp)Andrade, G. H.B. [UNESP]Simão, V. A. [UNESP]Souza, B. R. [UNESP]Chuffa, L. G.A. [UNESP]Camargo, I. C.C. [UNESP]2018-12-11T16:52:31Z2018-12-11T16:52:31Z2018-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article79-88application/pdfhttp://dx.doi.org/10.1016/j.tice.2018.01.001Tissue and Cell, v. 50, p. 79-88.1532-30720040-8166http://hdl.handle.net/11449/17081010.1016/j.tice.2018.01.0012-s2.0-850442614252-s2.0-85044261425.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTissue and Cell0,410info:eu-repo/semantics/openAccess2024-01-10T06:23:37Zoai:repositorio.unesp.br:11449/170810Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:35:23.930845Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
title Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
spellingShingle Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
Andrade, G. H.B. [UNESP]
Fallopian tube
Nandrolone decanoate
Sex steroids receptors
title_short Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
title_full Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
title_fullStr Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
title_full_unstemmed Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
title_sort Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses
author Andrade, G. H.B. [UNESP]
author_facet Andrade, G. H.B. [UNESP]
Simão, V. A. [UNESP]
Souza, B. R. [UNESP]
Chuffa, L. G.A. [UNESP]
Camargo, I. C.C. [UNESP]
author_role author
author2 Simão, V. A. [UNESP]
Souza, B. R. [UNESP]
Chuffa, L. G.A. [UNESP]
Camargo, I. C.C. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Andrade, G. H.B. [UNESP]
Simão, V. A. [UNESP]
Souza, B. R. [UNESP]
Chuffa, L. G.A. [UNESP]
Camargo, I. C.C. [UNESP]
dc.subject.por.fl_str_mv Fallopian tube
Nandrolone decanoate
Sex steroids receptors
topic Fallopian tube
Nandrolone decanoate
Sex steroids receptors
description Anabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods. The control group received mineral oil. Estrous cycle was monitored daily during both periods and in sequence the rats (n = 8/group/period) were killed. All ND-treated animals showed estral acyclicity during the PT and PR periods, but the histomorphometric changes in the fallopian tube varied according to the ND dose level. The expression of AR, ERα and ERβ varied in the nucleus and cytoplasm of epithelial cells. No AR expression was observed in the stroma. The muscle cells exhibited variation in immunostaining. In conclusion, ND promoted histomorphometric and immunohistochemical changes in the ampullary portion of the fallopian tube after treatment and recovery periods in a dose-independent manner.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T16:52:31Z
2018-12-11T16:52:31Z
2018-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tice.2018.01.001
Tissue and Cell, v. 50, p. 79-88.
1532-3072
0040-8166
http://hdl.handle.net/11449/170810
10.1016/j.tice.2018.01.001
2-s2.0-85044261425
2-s2.0-85044261425.pdf
url http://dx.doi.org/10.1016/j.tice.2018.01.001
http://hdl.handle.net/11449/170810
identifier_str_mv Tissue and Cell, v. 50, p. 79-88.
1532-3072
0040-8166
10.1016/j.tice.2018.01.001
2-s2.0-85044261425
2-s2.0-85044261425.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tissue and Cell
0,410
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 79-88
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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