The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/CCID.S281901 http://hdl.handle.net/11449/207357 |
Resumo: | Purpose: Botulinum toxin type A is an effective treatment for glabellar dynamic wrinkles. As the muscular group involved in the contraction of the glabella varies among people, individualized treatment can achieve optimal results. This study evaluates a customized assessment for the treatment of glabellar lines with Incobotulinumtoxin-A, leading to an individualized points distribution and dosage. Patients and Methods: A single-center, evaluator-blinded, therapeutic cohort study enrolled 130 women with moderate or severe glabellar wrinkles. They underwent Incobotulinumtoxin-A injection following the standard 5-point injection at the glabellar muscles (n = 65) or an individualized assessment and scheme treatment based on anatomical references of contraction, the One21 technique (n = 65). All the patients were photographed under maximum contraction before treatment (T0) and after 4 weeks (T28). The photos were randomly assessed by two blinded, experienced raters to consensually grade the severity according to the Merz Aesthetics Scales (MAS). The primary clinical efficacy was defined as a 2-point reduction in the MAS score, on Day 28. Results: The groups were homogeneous regarding age, phototype, and baseline MAS scores. On Day 28 (T28), 64 (98.5%) patients from the One21 group and 52 (80%) from the 5-point group reduced the MAS score by at least two points (p < 0.01). When adjusted by age and phototype, both groups reduced the MAS score at T28 (p < 0.01); nevertheless, patients from the One21 group significantly performed better (p < 0.01), with a much higher rate response rate at T28, in comparison to the 5-point group. Of patients enrolled in the 5-point group, 83.1% utilized muscle groups other than the procerus and corrugator in glabellar wrinkle formation, and 17 (24.6%) presented asymmetrical contraction. Patients from the 5-point group with glabellar asymmetry and those who utilized the frontalis and orbicularis presented inferior performance (p < 0.05), reinfor- cing the importance of an individualized assessment and treatment plan. Conclusion: The One21 technique yielded better results than the standard 5-point treatment in reducing glabellar dynamic lines with Incobotulinumtoxin-A, especially for asymmetric lines of the glabella or the involvement of muscle groups other than the procerus and corrugator. |
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The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarksBotulinum toxin type Aevaluation studies as a topicfaceGlabellaincobotulinumtoxinaMuscle contractionTreatmentPurpose: Botulinum toxin type A is an effective treatment for glabellar dynamic wrinkles. As the muscular group involved in the contraction of the glabella varies among people, individualized treatment can achieve optimal results. This study evaluates a customized assessment for the treatment of glabellar lines with Incobotulinumtoxin-A, leading to an individualized points distribution and dosage. Patients and Methods: A single-center, evaluator-blinded, therapeutic cohort study enrolled 130 women with moderate or severe glabellar wrinkles. They underwent Incobotulinumtoxin-A injection following the standard 5-point injection at the glabellar muscles (n = 65) or an individualized assessment and scheme treatment based on anatomical references of contraction, the One21 technique (n = 65). All the patients were photographed under maximum contraction before treatment (T0) and after 4 weeks (T28). The photos were randomly assessed by two blinded, experienced raters to consensually grade the severity according to the Merz Aesthetics Scales (MAS). The primary clinical efficacy was defined as a 2-point reduction in the MAS score, on Day 28. Results: The groups were homogeneous regarding age, phototype, and baseline MAS scores. On Day 28 (T28), 64 (98.5%) patients from the One21 group and 52 (80%) from the 5-point group reduced the MAS score by at least two points (p < 0.01). When adjusted by age and phototype, both groups reduced the MAS score at T28 (p < 0.01); nevertheless, patients from the One21 group significantly performed better (p < 0.01), with a much higher rate response rate at T28, in comparison to the 5-point group. Of patients enrolled in the 5-point group, 83.1% utilized muscle groups other than the procerus and corrugator in glabellar wrinkle formation, and 17 (24.6%) presented asymmetrical contraction. Patients from the 5-point group with glabellar asymmetry and those who utilized the frontalis and orbicularis presented inferior performance (p < 0.05), reinfor- cing the importance of an individualized assessment and treatment plan. Conclusion: The One21 technique yielded better results than the standard 5-point treatment in reducing glabellar dynamic lines with Incobotulinumtoxin-A, especially for asymmetric lines of the glabella or the involvement of muscle groups other than the procerus and corrugator.Dermatologie - Clinica Cirurgia Cosmiatria e LaserDepartamento de Dermatologia da FMB-UnespDepartamento de Dermatologia da FMB-UnespCosmiatria e LaserUniversidade Estadual Paulista (Unesp)De Sanctis Pecora, CarlaPinheiro, Maria Valéria BussamaraFerreira, Karin VenturaDe Barros Nunes, Gisele JacobinoMiot, Hélio Amante [UNESP]2021-06-25T10:53:51Z2021-06-25T10:53:51Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article97-105http://dx.doi.org/10.2147/CCID.S281901Clinical, Cosmetic and Investigational Dermatology, v. 14, p. 97-105.1178-7015http://hdl.handle.net/11449/20735710.2147/CCID.S2819012-s2.0-85101604567Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical, Cosmetic and Investigational Dermatologyinfo:eu-repo/semantics/openAccess2024-08-14T18:45:44Zoai:repositorio.unesp.br:11449/207357Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:45:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
title |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
spellingShingle |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks De Sanctis Pecora, Carla Botulinum toxin type A evaluation studies as a topic face Glabella incobotulinumtoxina Muscle contraction Treatment |
title_short |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
title_full |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
title_fullStr |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
title_full_unstemmed |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
title_sort |
The one21 technique: An individualized treatment for glabellar lines based on clinical and anatomical landmarks |
author |
De Sanctis Pecora, Carla |
author_facet |
De Sanctis Pecora, Carla Pinheiro, Maria Valéria Bussamara Ferreira, Karin Ventura De Barros Nunes, Gisele Jacobino Miot, Hélio Amante [UNESP] |
author_role |
author |
author2 |
Pinheiro, Maria Valéria Bussamara Ferreira, Karin Ventura De Barros Nunes, Gisele Jacobino Miot, Hélio Amante [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Cosmiatria e Laser Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
De Sanctis Pecora, Carla Pinheiro, Maria Valéria Bussamara Ferreira, Karin Ventura De Barros Nunes, Gisele Jacobino Miot, Hélio Amante [UNESP] |
dc.subject.por.fl_str_mv |
Botulinum toxin type A evaluation studies as a topic face Glabella incobotulinumtoxina Muscle contraction Treatment |
topic |
Botulinum toxin type A evaluation studies as a topic face Glabella incobotulinumtoxina Muscle contraction Treatment |
description |
Purpose: Botulinum toxin type A is an effective treatment for glabellar dynamic wrinkles. As the muscular group involved in the contraction of the glabella varies among people, individualized treatment can achieve optimal results. This study evaluates a customized assessment for the treatment of glabellar lines with Incobotulinumtoxin-A, leading to an individualized points distribution and dosage. Patients and Methods: A single-center, evaluator-blinded, therapeutic cohort study enrolled 130 women with moderate or severe glabellar wrinkles. They underwent Incobotulinumtoxin-A injection following the standard 5-point injection at the glabellar muscles (n = 65) or an individualized assessment and scheme treatment based on anatomical references of contraction, the One21 technique (n = 65). All the patients were photographed under maximum contraction before treatment (T0) and after 4 weeks (T28). The photos were randomly assessed by two blinded, experienced raters to consensually grade the severity according to the Merz Aesthetics Scales (MAS). The primary clinical efficacy was defined as a 2-point reduction in the MAS score, on Day 28. Results: The groups were homogeneous regarding age, phototype, and baseline MAS scores. On Day 28 (T28), 64 (98.5%) patients from the One21 group and 52 (80%) from the 5-point group reduced the MAS score by at least two points (p < 0.01). When adjusted by age and phototype, both groups reduced the MAS score at T28 (p < 0.01); nevertheless, patients from the One21 group significantly performed better (p < 0.01), with a much higher rate response rate at T28, in comparison to the 5-point group. Of patients enrolled in the 5-point group, 83.1% utilized muscle groups other than the procerus and corrugator in glabellar wrinkle formation, and 17 (24.6%) presented asymmetrical contraction. Patients from the 5-point group with glabellar asymmetry and those who utilized the frontalis and orbicularis presented inferior performance (p < 0.05), reinfor- cing the importance of an individualized assessment and treatment plan. Conclusion: The One21 technique yielded better results than the standard 5-point treatment in reducing glabellar dynamic lines with Incobotulinumtoxin-A, especially for asymmetric lines of the glabella or the involvement of muscle groups other than the procerus and corrugator. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:53:51Z 2021-06-25T10:53:51Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/CCID.S281901 Clinical, Cosmetic and Investigational Dermatology, v. 14, p. 97-105. 1178-7015 http://hdl.handle.net/11449/207357 10.2147/CCID.S281901 2-s2.0-85101604567 |
url |
http://dx.doi.org/10.2147/CCID.S281901 http://hdl.handle.net/11449/207357 |
identifier_str_mv |
Clinical, Cosmetic and Investigational Dermatology, v. 14, p. 97-105. 1178-7015 10.2147/CCID.S281901 2-s2.0-85101604567 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical, Cosmetic and Investigational Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
97-105 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128141406765056 |