Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11356-020-08389-w http://hdl.handle.net/11449/200295 |
Resumo: | Benzimidazoles are anthelmintics frequently used in sheep farming due to the high susceptibility of these animals to parasitic diseases. Sheep excreta are often disposed onto soils as a fertilizer, and they may contain benzimidazole residues that can contaminate soil and water. This work aimed to assess the leaching behavior of benzimidazole drugs (albendazole, fenbendazole, and thiabendazole) and their metabolites in two Brazilian soils of different textural classifications (sandy and clay), as well as sheep excreta-amended soils, following the OECD 312 Guidelines. Ewes received a single oral dose of 10 mg kg−1 b.w. of either albendazole or fenbendazole. The feces were collected at 24, 48, 72, 96, and 120 h post-dose, and the parent drugs and their metabolites extracted using the QuEChERS approach and quantified by UHPLC-MS/MS. For the leaching assays, a benzimidazole solution was directly applied onto the soil columns, or an amount of 5 g of the medicated sheep feces was distributed over the top of the soil columns. In soil samples, benzimidazoles were extracted by solid-liquid extraction and quantified by UHPLC-MS/MS. For the leaching studies, atrazine was used as a reference substance to determine the relative mobility factor of the analytes of interest. Benzimidazoles were considered slightly to moderately mobile in both soils tested, with a leaching distance of up to 25 cm in a 30-cm soil column. Approximately 3 to 6% of the benzimidazoles present in ewe feces were able to leach into the soil columns. This finding is of concern since benzimidazoles are persistent in soil and may pose a risk to soil biota and induce the development of resistant strains of parasites. |
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Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excretaBenzimidazoles and metabolitesBrazilian soilsLeaching behaviorMobility in soilSheep fecesUHPLC-MS/MSBenzimidazoles are anthelmintics frequently used in sheep farming due to the high susceptibility of these animals to parasitic diseases. Sheep excreta are often disposed onto soils as a fertilizer, and they may contain benzimidazole residues that can contaminate soil and water. This work aimed to assess the leaching behavior of benzimidazole drugs (albendazole, fenbendazole, and thiabendazole) and their metabolites in two Brazilian soils of different textural classifications (sandy and clay), as well as sheep excreta-amended soils, following the OECD 312 Guidelines. Ewes received a single oral dose of 10 mg kg−1 b.w. of either albendazole or fenbendazole. The feces were collected at 24, 48, 72, 96, and 120 h post-dose, and the parent drugs and their metabolites extracted using the QuEChERS approach and quantified by UHPLC-MS/MS. For the leaching assays, a benzimidazole solution was directly applied onto the soil columns, or an amount of 5 g of the medicated sheep feces was distributed over the top of the soil columns. In soil samples, benzimidazoles were extracted by solid-liquid extraction and quantified by UHPLC-MS/MS. For the leaching studies, atrazine was used as a reference substance to determine the relative mobility factor of the analytes of interest. Benzimidazoles were considered slightly to moderately mobile in both soils tested, with a leaching distance of up to 25 cm in a 30-cm soil column. Approximately 3 to 6% of the benzimidazoles present in ewe feces were able to leach into the soil columns. This finding is of concern since benzimidazoles are persistent in soil and may pose a risk to soil biota and induce the development of resistant strains of parasites.Institute of Chemistry Department of Analytical Chemistry University of Campinas, P.O. Box 6154Department of Biology and Animal Science São Paulo State University (UNESP) School of Engineering (FEIS)Department of Biology and Animal Science São Paulo State University (UNESP) School of Engineering (FEIS)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Porto, Rafael SilveiraPinheiro, Rafael Silvio Bonilha [UNESP]Rath, Susanne2020-12-12T02:02:52Z2020-12-12T02:02:52Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s11356-020-08389-wEnvironmental Science and Pollution Research.1614-74990944-1344http://hdl.handle.net/11449/20029510.1007/s11356-020-08389-w2-s2.0-8508339889597302549957806150000-0003-1713-8375Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Researchinfo:eu-repo/semantics/openAccess2024-07-04T15:32:50Zoai:repositorio.unesp.br:11449/200295Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:59:00.155811Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
title |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
spellingShingle |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta Porto, Rafael Silveira Benzimidazoles and metabolites Brazilian soils Leaching behavior Mobility in soil Sheep feces UHPLC-MS/MS |
title_short |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
title_full |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
title_fullStr |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
title_full_unstemmed |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
title_sort |
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta |
author |
Porto, Rafael Silveira |
author_facet |
Porto, Rafael Silveira Pinheiro, Rafael Silvio Bonilha [UNESP] Rath, Susanne |
author_role |
author |
author2 |
Pinheiro, Rafael Silvio Bonilha [UNESP] Rath, Susanne |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Porto, Rafael Silveira Pinheiro, Rafael Silvio Bonilha [UNESP] Rath, Susanne |
dc.subject.por.fl_str_mv |
Benzimidazoles and metabolites Brazilian soils Leaching behavior Mobility in soil Sheep feces UHPLC-MS/MS |
topic |
Benzimidazoles and metabolites Brazilian soils Leaching behavior Mobility in soil Sheep feces UHPLC-MS/MS |
description |
Benzimidazoles are anthelmintics frequently used in sheep farming due to the high susceptibility of these animals to parasitic diseases. Sheep excreta are often disposed onto soils as a fertilizer, and they may contain benzimidazole residues that can contaminate soil and water. This work aimed to assess the leaching behavior of benzimidazole drugs (albendazole, fenbendazole, and thiabendazole) and their metabolites in two Brazilian soils of different textural classifications (sandy and clay), as well as sheep excreta-amended soils, following the OECD 312 Guidelines. Ewes received a single oral dose of 10 mg kg−1 b.w. of either albendazole or fenbendazole. The feces were collected at 24, 48, 72, 96, and 120 h post-dose, and the parent drugs and their metabolites extracted using the QuEChERS approach and quantified by UHPLC-MS/MS. For the leaching assays, a benzimidazole solution was directly applied onto the soil columns, or an amount of 5 g of the medicated sheep feces was distributed over the top of the soil columns. In soil samples, benzimidazoles were extracted by solid-liquid extraction and quantified by UHPLC-MS/MS. For the leaching studies, atrazine was used as a reference substance to determine the relative mobility factor of the analytes of interest. Benzimidazoles were considered slightly to moderately mobile in both soils tested, with a leaching distance of up to 25 cm in a 30-cm soil column. Approximately 3 to 6% of the benzimidazoles present in ewe feces were able to leach into the soil columns. This finding is of concern since benzimidazoles are persistent in soil and may pose a risk to soil biota and induce the development of resistant strains of parasites. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:02:52Z 2020-12-12T02:02:52Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11356-020-08389-w Environmental Science and Pollution Research. 1614-7499 0944-1344 http://hdl.handle.net/11449/200295 10.1007/s11356-020-08389-w 2-s2.0-85083398895 9730254995780615 0000-0003-1713-8375 |
url |
http://dx.doi.org/10.1007/s11356-020-08389-w http://hdl.handle.net/11449/200295 |
identifier_str_mv |
Environmental Science and Pollution Research. 1614-7499 0944-1344 10.1007/s11356-020-08389-w 2-s2.0-85083398895 9730254995780615 0000-0003-1713-8375 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Science and Pollution Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129569297793024 |