Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/231114 |
Resumo: | Purpose: The aim of this study was to perform qualitative and quantitative analyses of the effect of nicotine on autogenous bone block grafts and to describe events in the initial healing phase and the differences in the repair processes between animals exposed to nicotine and controls. Materials and Methods: Forty-eight female Wistar rats were randomly divided into 2 groups, the nicotine group and the saline group. All animals received either nicotine (3 mg/kg) or saline 4 weeks before the surgical procedure and continued to receive nicotine from surgery to sacrifice at 7, 14, or 28 days. The autogenous bone block graft was harvested from the calvaria and stabilized on the external cortical area near the angle of the mandible. Results: The histologic analyses of the nicotine group depicted a delay in osteogenic activity at the bed-graft interface, as well as impairment of the organization of the granulation tissue that developed instead of blood clot. Nicotine-group specimens exhibited less bone neoformation, and the newly formed bone was poorly cellularized and vascularized. The histometric analysis revealed significantly less bone formation in the nicotine group at both 14 days (23.75% ± 6.18% versus 51.31% ± 8.31%) and 28 days (42.44% t 8.70% versus 73.00% ± 4.99%). Conclusion: Nicotine did Jeopardize the early healing process of autogenous bone block grafts in rats but did not prevent it. |
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Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in ratsAutograftBone graftingNicotineWound healingPurpose: The aim of this study was to perform qualitative and quantitative analyses of the effect of nicotine on autogenous bone block grafts and to describe events in the initial healing phase and the differences in the repair processes between animals exposed to nicotine and controls. Materials and Methods: Forty-eight female Wistar rats were randomly divided into 2 groups, the nicotine group and the saline group. All animals received either nicotine (3 mg/kg) or saline 4 weeks before the surgical procedure and continued to receive nicotine from surgery to sacrifice at 7, 14, or 28 days. The autogenous bone block graft was harvested from the calvaria and stabilized on the external cortical area near the angle of the mandible. Results: The histologic analyses of the nicotine group depicted a delay in osteogenic activity at the bed-graft interface, as well as impairment of the organization of the granulation tissue that developed instead of blood clot. Nicotine-group specimens exhibited less bone neoformation, and the newly formed bone was poorly cellularized and vascularized. The histometric analysis revealed significantly less bone formation in the nicotine group at both 14 days (23.75% ± 6.18% versus 51.31% ± 8.31%) and 28 days (42.44% t 8.70% versus 73.00% ± 4.99%). Conclusion: Nicotine did Jeopardize the early healing process of autogenous bone block grafts in rats but did not prevent it.Dental School of Araçatuba University of São PauloDepartment of Biological Sciences Bauru Dental School University of Säo PauloRua Vivaldo Guimarães, no 17-62 Jardim Dona Sarah, CEP:17012-120, Bauru, São PauloUniversidade de São Paulo (USP)University of Säo PauloRua Vivaldo GuimarãesBonfante, SamaraBosco, Alvaro FranciscoLuize, Danielle ShimaDe Almeida, Juliano MilaneziCestari, Tania MaryTaga, Rumio2022-04-29T08:43:43Z2022-04-29T08:43:43Z2008-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article437-444International Journal of Oral and Maxillofacial Implants, v. 23, n. 3, p. 437-444, 2008.0882-2786http://hdl.handle.net/11449/2311142-s2.0-47249157652Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Oral and Maxillofacial Implants14707234699info:eu-repo/semantics/openAccess2024-04-23T15:24:01Zoai:repositorio.unesp.br:11449/231114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:48:36.567231Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
title |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
spellingShingle |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats Bonfante, Samara Autograft Bone grafting Nicotine Wound healing |
title_short |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
title_full |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
title_fullStr |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
title_full_unstemmed |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
title_sort |
Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats |
author |
Bonfante, Samara |
author_facet |
Bonfante, Samara Bosco, Alvaro Francisco Luize, Danielle Shima De Almeida, Juliano Milanezi Cestari, Tania Mary Taga, Rumio |
author_role |
author |
author2 |
Bosco, Alvaro Francisco Luize, Danielle Shima De Almeida, Juliano Milanezi Cestari, Tania Mary Taga, Rumio |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) University of Säo Paulo Rua Vivaldo Guimarães |
dc.contributor.author.fl_str_mv |
Bonfante, Samara Bosco, Alvaro Francisco Luize, Danielle Shima De Almeida, Juliano Milanezi Cestari, Tania Mary Taga, Rumio |
dc.subject.por.fl_str_mv |
Autograft Bone grafting Nicotine Wound healing |
topic |
Autograft Bone grafting Nicotine Wound healing |
description |
Purpose: The aim of this study was to perform qualitative and quantitative analyses of the effect of nicotine on autogenous bone block grafts and to describe events in the initial healing phase and the differences in the repair processes between animals exposed to nicotine and controls. Materials and Methods: Forty-eight female Wistar rats were randomly divided into 2 groups, the nicotine group and the saline group. All animals received either nicotine (3 mg/kg) or saline 4 weeks before the surgical procedure and continued to receive nicotine from surgery to sacrifice at 7, 14, or 28 days. The autogenous bone block graft was harvested from the calvaria and stabilized on the external cortical area near the angle of the mandible. Results: The histologic analyses of the nicotine group depicted a delay in osteogenic activity at the bed-graft interface, as well as impairment of the organization of the granulation tissue that developed instead of blood clot. Nicotine-group specimens exhibited less bone neoformation, and the newly formed bone was poorly cellularized and vascularized. The histometric analysis revealed significantly less bone formation in the nicotine group at both 14 days (23.75% ± 6.18% versus 51.31% ± 8.31%) and 28 days (42.44% t 8.70% versus 73.00% ± 4.99%). Conclusion: Nicotine did Jeopardize the early healing process of autogenous bone block grafts in rats but did not prevent it. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-05-01 2022-04-29T08:43:43Z 2022-04-29T08:43:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
International Journal of Oral and Maxillofacial Implants, v. 23, n. 3, p. 437-444, 2008. 0882-2786 http://hdl.handle.net/11449/231114 2-s2.0-47249157652 |
identifier_str_mv |
International Journal of Oral and Maxillofacial Implants, v. 23, n. 3, p. 437-444, 2008. 0882-2786 2-s2.0-47249157652 |
url |
http://hdl.handle.net/11449/231114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Oral and Maxillofacial Implants 14707 234699 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
437-444 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129464437047296 |