Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1017/S0950268817003053 http://hdl.handle.net/11449/160086 |
Resumo: | Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year. The incidence of VL was estimated by means of serological and molecular diagnostic tests, 180 and 360 days after the application of the control measures. The estimates of the effectiveness (EF) were not significant in any cohort. The EF of the subunit vaccine, the recombinant vaccine and the collar were 26.4%, 32.8% and 57.7% and the upper limit of the 95% confidence interval for EF were 63.7%, 67.9% and 82.5%, respectively. In conclusion, under the conditions of this study, none of the immunogens for VL control was sufficiently effective to protect dogs against infection. On the other hand, use of collars impregnated with insecticide seems to constitute a method with better prognosis, corroborating other studies in this field. |
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Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in BrazilCanine visceral leishmaniosiscohort studycontrol methodseffectivenessinsecticide-impregnated collarvaccineAlthough a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year. The incidence of VL was estimated by means of serological and molecular diagnostic tests, 180 and 360 days after the application of the control measures. The estimates of the effectiveness (EF) were not significant in any cohort. The EF of the subunit vaccine, the recombinant vaccine and the collar were 26.4%, 32.8% and 57.7% and the upper limit of the 95% confidence interval for EF were 63.7%, 67.9% and 82.5%, respectively. In conclusion, under the conditions of this study, none of the immunogens for VL control was sufficiently effective to protect dogs against infection. On the other hand, use of collars impregnated with insecticide seems to constitute a method with better prognosis, corroborating other studies in this field.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Sao Paulo, SP, BrazilUniv Estadual Paulista, Fac Med Vet, Dept Med Vet, Campus Aracatuba, Aracatuba, SP, BrazilUniv Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Med Vet, Pirassununga, SP, BrazilAdolfo Lutz Inst, Ctr Parasitol & Micol, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP, BrazilUniv Estadual Paulista, Fac Med Vet, Dept Med Vet, Campus Aracatuba, Aracatuba, SP, BrazilFAPESP: 2011/21796-2FAPESP: 2011/14892-5Cambridge Univ PressUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Adolfo Lutz InstLopes, E. G.Seva, A. P.Ferreira, F.Nunes, C. M. [UNESP]Keid, L. B.Hiramoto, R. M.Ferreira, H. L.Oliveira, T. M. F. S.Ovallos, F. G.Galati, E. A. B.Villegas, T. J.Bortoletto, D. V. [UNESP]Valadas, S. Y. O. B.Soares, R. M.2018-11-26T15:47:26Z2018-11-26T15:47:26Z2018-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article401-406application/pdfhttp://dx.doi.org/10.1017/S0950268817003053Epidemiology And Infection. New York: Cambridge Univ Press, v. 146, n. 3, p. 401-406, 2018.0950-2688http://hdl.handle.net/11449/16008610.1017/S0950268817003053WOS:000424741000019WOS000424741000019.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEpidemiology And Infection1,128info:eu-repo/semantics/openAccess2023-10-11T06:04:47Zoai:repositorio.unesp.br:11449/160086Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:36:12.498533Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
title |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
spellingShingle |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil Lopes, E. G. Canine visceral leishmaniosis cohort study control methods effectiveness insecticide-impregnated collar vaccine |
title_short |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
title_full |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
title_fullStr |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
title_full_unstemmed |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
title_sort |
Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil |
author |
Lopes, E. G. |
author_facet |
Lopes, E. G. Seva, A. P. Ferreira, F. Nunes, C. M. [UNESP] Keid, L. B. Hiramoto, R. M. Ferreira, H. L. Oliveira, T. M. F. S. Ovallos, F. G. Galati, E. A. B. Villegas, T. J. Bortoletto, D. V. [UNESP] Valadas, S. Y. O. B. Soares, R. M. |
author_role |
author |
author2 |
Seva, A. P. Ferreira, F. Nunes, C. M. [UNESP] Keid, L. B. Hiramoto, R. M. Ferreira, H. L. Oliveira, T. M. F. S. Ovallos, F. G. Galati, E. A. B. Villegas, T. J. Bortoletto, D. V. [UNESP] Valadas, S. Y. O. B. Soares, R. M. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Adolfo Lutz Inst |
dc.contributor.author.fl_str_mv |
Lopes, E. G. Seva, A. P. Ferreira, F. Nunes, C. M. [UNESP] Keid, L. B. Hiramoto, R. M. Ferreira, H. L. Oliveira, T. M. F. S. Ovallos, F. G. Galati, E. A. B. Villegas, T. J. Bortoletto, D. V. [UNESP] Valadas, S. Y. O. B. Soares, R. M. |
dc.subject.por.fl_str_mv |
Canine visceral leishmaniosis cohort study control methods effectiveness insecticide-impregnated collar vaccine |
topic |
Canine visceral leishmaniosis cohort study control methods effectiveness insecticide-impregnated collar vaccine |
description |
Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year. The incidence of VL was estimated by means of serological and molecular diagnostic tests, 180 and 360 days after the application of the control measures. The estimates of the effectiveness (EF) were not significant in any cohort. The EF of the subunit vaccine, the recombinant vaccine and the collar were 26.4%, 32.8% and 57.7% and the upper limit of the 95% confidence interval for EF were 63.7%, 67.9% and 82.5%, respectively. In conclusion, under the conditions of this study, none of the immunogens for VL control was sufficiently effective to protect dogs against infection. On the other hand, use of collars impregnated with insecticide seems to constitute a method with better prognosis, corroborating other studies in this field. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T15:47:26Z 2018-11-26T15:47:26Z 2018-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1017/S0950268817003053 Epidemiology And Infection. New York: Cambridge Univ Press, v. 146, n. 3, p. 401-406, 2018. 0950-2688 http://hdl.handle.net/11449/160086 10.1017/S0950268817003053 WOS:000424741000019 WOS000424741000019.pdf |
url |
http://dx.doi.org/10.1017/S0950268817003053 http://hdl.handle.net/11449/160086 |
identifier_str_mv |
Epidemiology And Infection. New York: Cambridge Univ Press, v. 146, n. 3, p. 401-406, 2018. 0950-2688 10.1017/S0950268817003053 WOS:000424741000019 WOS000424741000019.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Epidemiology And Infection 1,128 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
401-406 application/pdf |
dc.publisher.none.fl_str_mv |
Cambridge Univ Press |
publisher.none.fl_str_mv |
Cambridge Univ Press |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128385677787136 |